Catalog No.
YHD78701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met41-Phe254
Predicted molecular weight
50.26 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P28340
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
3'-5' exodeoxyribonuclease, DNA polymerase subunit delta p125, POLD1, DNA polymerase delta catalytic subunit, POLD
Multicenter phase Ib/II study of second-line durvalumab and tremelimumab in combination with paclitaxel in patients with biomarker-selected metastatic gastric cancer., PMID:40399487
DNA glycosylase (NEIL3) overexpression associated with low tumor immune infiltration and poor overall patient survival in endometrial cancer., PMID:40348794
The protein deacetylase HDAC10 controls DNA replication in malignant lymphoid cells., PMID:40301616
Specificity protein 1 (SP1) plays an essential role in early bovine embryo development., PMID:40286422
Germline variants in patients from the Iranian hereditary colorectal cancer registry., PMID:40223084
Survival expectations in melanoma patients: a molecular prognostic model associated with aging., PMID:40019657
SRF/SLC31A1 signaling promotes cuproptosis induced by celastrol in NSCLC., PMID:39930648
Helicobacter pylori infection induces DNA double-strand breaks through the ACVR1/IRF3/POLD1 signaling axis to drive gastric tumorigenesis., PMID:39924917
Targeting the splicing factor SNRPB inhibits endometrial cancer progression by retaining the POLD1 intron., PMID:39910288
Genomic profiles of patients with skin melanoma in the era of immune checkpoint inhibitors., PMID:39888082
Transcriptome analysis reveals the DNA replication genes response to Vibrio anguillarum and NNV infection in Jinhu grouper (Epinephelus fuscoguttatus♀ × Epinephelus tukulal♂)., PMID:39813918
Immune Checkpoint Blockade Delays Cancer Development and Extends Survival in DNA Polymerase Mutator Syndromes., PMID:39786467
Integrated Analysis of Polymerase Family Gene Mutations in Acute Myeloid Leukemia: Clinical Features, Prognosis, and Bioinformatics Insights., PMID:39768855
Transcriptional analysis reveals the suppression of RAD51 and disruption of the homologous recombination pathway during PEDV infection in IPEC-J2 cells., PMID:39731192
Identification and evaluation of plasma exosome RNA biomarkers for non-invasive diagnosis of hepatocellular carcinoma using RNA-seq., PMID:39696145
p12 isoform-2 is a regulatory subunit of human DNA polymerase delta and is dysregulated in various cancers., PMID:39626050
When do the pathological signs become evident? Study of human mesenchymal stem cells in MDPL syndrome., PMID:39611849
Maximal clique centrality and bottleneck genes as novel biomarkers in ovarian cancer., PMID:39305503
Molecular substratification of endometrial carcinomas with no special molecular profile (NSMP) by using a limited NGS custom panel may facilitate effective patient selection for the PIK3CA-targeted therapy., PMID:39235514
A phase II clinical trial of toripalimab in advanced solid tumors with polymerase epsilon/polymerase delta (POLE/POLD1) mutation., PMID:39218995
NMN partially rescues cuproptosis by upregulating sirt2 to increase intracellular NADPH., PMID:39169144
Synthetic lethality between ATR and POLA1 reveals a potential new target for individualized cancer therapy., PMID:39128273
The expression spectrum of yak epididymal epithelial cells reveals the functional diversity of caput, corpus and cauda regions., PMID:39117249
Targeting POLD1 to suppress the proliferation and migration of breast cancer MDA-MB-231 cell lines by downregulation of SIRT1., PMID:39036524
Comprehensive genomic analysis of adrenocortical carcinoma reveals genetic profiles associated with patient survival., PMID:38935991
Harmine inhibits pulmonary fibrosis through regulating DNA damage repair-related genes and activation of TP53-Gadd45α pathway., PMID:38924867
Proofreading the way: immune checkpoint inhibitors in polymerase ε/polymerase δ (POLE/POLD1)-altered colorectal cancer., PMID:38910015
Neoadjuvant camrelizumab plus apatinib for locally advanced microsatellite instability-high or mismatch repair-deficient colorectal cancer (NEOCAP): a single-arm, open-label, phase 2 study., PMID:38852601
Immune checkpoint inhibitors for POLE or POLD1 proofreading-deficient metastatic colorectal cancer., PMID:38777726
A comprehensive analysis of POLE/POLD1 genomic alterations in colorectal cancer., PMID:38776551
Discovery of recessive effect of human polymerase δ proofreading deficiency through mutational analysis of POLD1-mutated normal and cancer cells., PMID:38658779
Macroscopic inhibition of DNA damage repair pathways by targeting AP-2α with LEI110 eradicates hepatocellular carcinoma., PMID:38503825
POLD1 Is Required for Cell Cycle Progression by Overcoming DNA Damage in Malignant Pleural Mesothelioma., PMID:38423601
Multiple duodenal epithelial tumors in a patient with polymerase proofreading-associated polyposis in POLE variant., PMID:38386255
Altered immunoexpression of DNA polymerase delta 1 catalytic subunit (POLD1) in colorectal cancer., PMID:38239863
Race, Prevalence of POLE and POLD1 Alterations, and Survival Among Patients With Endometrial Cancer., PMID:38231514
DNA polymerase ε and δ variants drive mutagenesis in polypurine tracts in human tumors., PMID:38219146
Molecular and Clinicopathologic Characterization of Mismatch Repair-Deficient Endometrial Carcinoma Not Related to MLH1 Promoter Hypermethylation., PMID:38191122
Extracellular vesicle-derived TP53BP1, CD34, and PBX1 from human peripheral blood serve as potential biomarkers for the assessment and prediction of vascular aging., PMID:38173016
POLD1 DEDD Motif Mutation Confers Hypermutation in Endometrial Cancer and Durable Response to Pembrolizumab., PMID:38067377
Genomic Characteristics and Its Therapeutic Implications in Breast Cancer Patients with Detectable Molecular Residual Disease., PMID:38062709
Rare germline variants in POLE and POLD1 encoding the catalytic subunits of DNA polymerases ε and δ in glioma families., PMID:37990341
Identification of DNA damage response-related genes as biomarkers for castration-resistant prostate cancer., PMID:37950047
Recommendations for the classification of germline variants in the exonuclease domain of POLE and POLD1., PMID:37848928
Identification and validation of potential diagnostic signature and immune cell infiltration for NAFLD based on cuproptosis-related genes by bioinformatics analysis and machine learning., PMID:37822923
Case Report: Cancer spectrum and genetic characteristics of a de novo germline POLD1 p.L606M variant-induced polyposis syndrome., PMID:37746257
Downregulation of Krüppel-like factor 14 accelerated cellular senescence and aging., PMID:37551728
RNA-Sequencing Analysis Indicates That N-Cadherin Promotes Prostate Cancer Progression by the Epigenetic Modification of Key Genes., PMID:37540080
[Clinicopathological and gene mutation characteristics of uterine carcinosarcoma]., PMID:37357193
Integrating POLE/POLD1 mutated for immunotherapy treatment planning of advanced stage non-small cell lung cancer., PMID:37345618
For research use only. Not for human or drug use.
