Catalog No.
YHD77401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Pro425-Ser659
Predicted molecular weight
29.01 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P28288
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ABCD3, 70 kDa peroxisomal membrane protein, ATP-binding cassette sub-family D member 3, PXMP1, PMP70
Molecular mechanism of substrate transport by human peroxisomal ABCD3., PMID:40501884
Integrated proteome and lipidome analyses place OCIAD1 at the mitochondria-peroxisome intersection balancing lipid metabolism., PMID:40211913
Quality control of ABCD3 by the VCP-FAF2 complex suppresses excessive pexophagy., PMID:39929145
A CCG expansion in ABCD3 causes oculopharyngodistal myopathy in individuals of European ancestry., PMID:39068203
Metabolomics Combined with Physiology and Transcriptomics Reveal the Response of Samsoniella hepiali to Key Metabolic Pathways and Its Degradation Mechanism during Subculture., PMID:39061849
HNF4A and HNF1A exhibit tissue specific target gene regulation in pancreatic beta cells and hepatocytes., PMID:38909044
Inhibition of VHL by VH298 Accelerates Pexophagy by Activation of HIF-1α in HeLa Cells., PMID:38257395
MAPL loss dysregulates bile and liver metabolism in mice., PMID:37962001
Rise and fall of peroxisomes during Alzheimer´s disease: a pilot study in human brains., PMID:37170361
SLC27A2 mediates FAO in colorectal cancer through nongenic crosstalk regulation of the PPARs pathway., PMID:37041476
The origin of long-chain fatty acids required for de novo ether lipid/plasmalogen synthesis., PMID:36990386
PEX13 prevents pexophagy by regulating ubiquitinated PEX5 and peroxisomal ROS., PMID:36541703
Development of a system adapted for the diagnosis and evaluation of peroxisomal disorders by measuring bile acid intermediates., PMID:36511274
Differential Gene Expression and Metabolic Pathway Analysis of Cladophora rupestris under Pb Stress Conditions., PMID:36360789
Genome-Wide Identification, Characterisation and Phylogenetic Analysis of 52 Striped Catfish (Pangasianodon hypophthalmus) ATP-Binding Cassette (ABC) Transporter Genes., PMID:35966264
ABCD3 is a prognostic biomarker for glioma and associated with immune infiltration: A study based on oncolysis of gliomas., PMID:35959373
Substrate Specificity and the Direction of Transport in the ABC Transporters ABCD1-3 and ABCD4., PMID:35908918
Protective effects of milk thistle (Sylibum marianum) seed oil and α-tocopherol against 7β-hydroxycholesterol-induced peroxisomal alterations in murine C2C12 myoblasts: Nutritional insights associated with the concept of pexotherapy., PMID:35381271
Mycobacterium tuberculosis Acetyltransferase Suppresses Oxidative Stress by Inducing Peroxisome Formation in Macrophages., PMID:35269727
INTS7-ABCD3 Interaction Stimulates the Proliferation and Osteoblastic Differentiation of Mouse Bone Marrow Mesenchymal Stem Cells by Suppressing Oxidative Stress., PMID:34880777
Ubiquitin ligase MARCH5 localizes to peroxisomes to regulate pexophagy., PMID:34747980
The peroxisomal transporter ABCD3 plays a major role in hepatic dicarboxylic fatty acid metabolism and lipid homeostasis., PMID:34564857
Infection of Glia by Human Pegivirus Suppresses Peroxisomal and Antiviral Signaling Pathways., PMID:34524914
Knockdown of PEX16 Induces Autophagic Degradation of Peroxisomes., PMID:34360754
Peroxisomal ABC Transporters: An Update., PMID:34198763
Murine deficiency of peroxisomal L-bifunctional protein (EHHADH) causes medium-chain 3-hydroxydicarboxylic aciduria and perturbs hepatic cholesterol homeostasis., PMID:34110423
Silencing PEX26 as an unconventional mode to kill drug-resistant cancer cells and forestall drug resistance., PMID:34074205
The effect of intracerebroventricular amyloid beta 1-42 application on cognitive functions in aged rats supplemented with taurine and the change of peroxisomal proteins in this process., PMID:33892084
Super-resolution imaging of flat-mounted whole mouse cornea., PMID:33610603
A missense allele of PEX5 is responsible for the defective import of PTS2 cargo proteins into peroxisomes., PMID:33389129
Multi-Omics Analysis of Diabetic Nephropathy Reveals Potential New Mechanisms and Drug Targets., PMID:33362869
Mass spectrometry-based abundance atlas of ABC transporters in human liver, gut, kidney, brain and skin., PMID:33128234
Prevention by Dietary Polyphenols (Resveratrol, Quercetin, Apigenin) Against 7-Ketocholesterol-Induced Oxiapoptophagy in Neuronal N2a Cells: Potential Interest for the Treatment of Neurodegenerative and Age-Related Diseases., PMID:33114025
Abnormal expression of ABCD3 is an independent prognostic factor for colorectal cancer., PMID:32269631
Organelle-specific autophagy in inflammatory diseases: a potential therapeutic target underlying the quality control of multiple organelles., PMID:32048886
Octadecaneuropeptide (ODN) Induces N2a Cells Differentiation through a PKA/PLC/PKC/MEK/ERK-Dependent Pathway: Incidence on Peroxisome, Mitochondria, and Lipid Profiles., PMID:31514417
Nilotinib interferes with cell cycle, ABC transporters and JAK-STAT signaling pathway in CD34+/lin- cells of patients with chronic phase chronic myeloid leukemia after 12 months of treatment., PMID:31318870
Initiation of the ABCD3-I algorithm for expediated evaluation of transient ischemic attack patients in an emergency department., PMID:31230922
Peroxisomal gene and protein expression increase in response to a high-lipid challenge in human skeletal muscle., PMID:31226353
Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether., PMID:31149896
Lysosomal inhibition attenuates peroxisomal gene transcription via suppression of PPARA and PPARGC1A levels., PMID:31032705
Oligomeric stability of Glossoscolex paulistus hemoglobin as a function of the storage time., PMID:30986471
Association of ABC gene profiles with time to progression and resistance in ovarian cancer revealed by bioinformatics analyses., PMID:30672151
TIA patients with higher ABCD3-I scores are prone to a higher incidence of intracranial stenosis, unstable carotid plaques and multiple-vessel involvement., PMID:30663969
Case report of dysregulation of primary bile acid synthesis in a family with X-linked adrenoleukodystrophy., PMID:30544401
Peroxisomes can oxidize medium- and long-chain fatty acids through a pathway involving ABCD3 and HSD17B4., PMID:30540494
TDRKH is a candidate gene for an autosomal dominant distal hereditary motor neuropathy., PMID:30503856
Bacillus licheniformis CK1 alleviates the toxic effects of zearalenone in feed on weaned female Tibetan piglets., PMID:30169611
Induction of peroxisomal changes in oligodendrocytes treated with 7-ketocholesterol: Attenuation by α-tocopherol., PMID:30031877
Changes in the activity of some metabolic enzymes in the heart of SHR rat incurred by transgenic expression of CD36., PMID:29916179
For research use only. Not for human or drug use.
