Catalog No.
YHD74301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Ser348
Predicted molecular weight
40.38 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P27540
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ARNT, Dioxin receptor, nuclear translocator, ARNT protein, bHLHe2, BHLHE2, Aryl hydrocarbon receptor nuclear translocator, Hypoxia-inducible factor 1-beta, HIF1-beta, Class E basic helix-loop-helix protein 2, HIF-1-beta
ATG9B-4 accelerates the proliferation and migration of liver cancer cells in an ARNTL-CDK5 pathway-dependent manner: A case-control study., PMID:40258750
Cigarette smoking modulates m6A modification, affecting the induction of CYP1A1 mRNA by regulating human ARNT and AHRR in A549 cells., PMID:40118351
ARNT-dependent HIF-2α signaling protects cardiac microvascular barrier integrity and heart function post-myocardial infarction., PMID:40089572
Predictive value and mediating effect analysis of the AHR-ARNT-CYP1A1 axis for missed abortion related to polycyclic aromatic hydrocarbons exposure., PMID:39929862
Structural basis for the ligand-dependent activation of heterodimeric AHR-ARNT complex., PMID:39900897
Atheroma transcriptomics identifies ARNTL as a smooth muscle cell regulator and with clinical and genetic data improves risk stratification., PMID:39552248
In Silico Exploration of AHR-HIF Pathway Interplay: Implications for Therapeutic Targeting in ccRCC., PMID:39336758
The promotion of cell proliferation and invasion in cutaneous squamous cell carcinomas after ARNT downregulation is associated with CXCL3., PMID:39312988
Next Generation SICLOPPS Screening for the Identification of Inhibitors of the HIF-1α/HIF-1β Protein-Protein Interaction., PMID:39312747
A Natural Chalcone Cardamonin Inhibited Transformation of Aryl Hydrocarbon Receptor Through Binding to the Receptor Competitively., PMID:39165052
Identification of small-molecule ligand-binding sites on and in the ARNT PAS-B domain., PMID:39059491
Endoplasmic reticulum exit sites are segregated for secretion based on cargo size., PMID:38991587
A dual role of ERGIC-localized Rabs in TMED10-mediated unconventional protein secretion., PMID:38926505
Targeting ARNT attenuates chemoresistance through destabilizing p38α-MAPK signaling in glioblastoma., PMID:38806469
Association of the AhR, ARNT, and AhRR gene polymorphisms and cord blood AhR levels with elevated cord blood IgE susceptibility in Taiwan mother-infant pairs: a nested case-control study., PMID:38590026
MIA3 promotes the degradation of GSH (glutathione) by binding to CHAC1, thereby promoting the progression of hepatocellular carcinoma., PMID:37948019
The AhR Signaling Mechanism: A Structural Point of View., PMID:37797832
Benvitimod Inhibits IL-4- and IL-13-Induced Tight Junction Impairment by Activating AHR/ARNT Pathway and Inhibiting STAT6 Phosphorylation in Human Keratinocytes., PMID:37734479
AhR and HIF-1α Signaling Pathways in Benign Meningioma under Hypoxia., PMID:37305351
TANGO1 interacts with NRTN to promote hepatocellular carcinoma progression by regulating the PI3K/AKT/mTOR signaling pathway., PMID:37211171
Evidence for crosstalk between the aryl hydrocarbon receptor and the translocator protein in mouse lung epithelial cells., PMID:37172753
Caspase 1 Enhances Transport and Golgi Organization Protein 1 Expression to Promote Procollagen Export From the Endoplasmic Reticulum in Systemic Sclerosis Contributing to Fibrosis., PMID:37067501
Hemato-vascular specification requires arnt1 and arnt2 genes in zebrafish embryos., PMID:37039097
Aryl hydrocarbon receptor nuclear translocator limits the recruitment and function of regulatory neutrophils against colorectal cancer by regulating the gut microbiota., PMID:36859266
Polymorphism, Expression, and Structure Analysis of a Key Gene ARNT in Sheep (Ovis aries)., PMID:36552304
Functions of the aryl hydrocarbon receptor (AHR) beyond the canonical AHR/ARNT signaling pathway., PMID:36528068
Structures of NPAS4-ARNT and NPAS4-ARNT2 heterodimers reveal new dimerization modalities in the bHLH-PAS transcription factor family., PMID:36343253
Sex-specific genetic association of brain and muscle Arnt-like protein-1 (BMAL1) and obesity in Chinese youth., PMID:36335026
Activation of γ-globin expression by hypoxia-inducible factor 1α., PMID:36224385
Melatonin Prevents against Ethanol-Induced Liver Injury by Mitigating Ferroptosis via Targeting Brain and Muscle ARNT-like 1 in Mice Liver and HepG2 Cells., PMID:36166594
Why ARNT Prostate Tumors Responding to Enzalutamide?, PMID:36052502
ARNT Inhibits H5N1 Influenza A Virus Replication by Interacting with the PA Protein., PMID:35891329
[Inhibitory effect of artesunate on bone destruction in rheumatoid arthritis: an exploration based on AhR/ARNT/NQO1 signaling pathway]., PMID:35718489
Interaction between AhR and HIF-1 signaling pathways mediated by ARNT/HIF-1β., PMID:35473600
Alternative Splicing of the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) Is Regulated by RBFOX2 in Lymphoid Malignancies., PMID:35404107
The Contribution of Genetic Variation and Aberrant Methylation of Aryl Hydrocarbon Receptor Signaling Pathway Genes to Rheumatoid Arthritis., PMID:35309329
AhR promotes phosphorylation of ARNT isoform 1 in human T cell malignancies as a switch for optimal AhR activity., PMID:35290121
Mitochondrial dysfunction associated with TANGO2 deficiency., PMID:35197517
Hypoxia-inducible factor-1β is essential for upregulation of the hypoxia-induced FLT1 gene in placental trophoblasts., PMID:34665260
Heritable disorders of oxygen sensing., PMID:34655169
The role of DNA-binding and ARNT dimerization on the nucleo-cytoplasmic translocation of the aryl hydrocarbon receptor., PMID:34521881
GPC5 suppresses lung cancer progression and metastasis via intracellular CTDSP1/AhR/ARNT signaling axis and extracellular exosome secretion., PMID:34079082
Melatonin prevents blood-retinal barrier breakdown and mitochondrial dysfunction in high glucose and hypoxia-induced in vitro diabetic macular edema model., PMID:33962019
Detrimental effects of hypoxia on glomerular podocytes., PMID:33835424
Identification of oral squamous cell carcinoma markers MUC2 and SPRR1B downstream of TANGO., PMID:33620575
Aryl hydrocarbon receptor deficiency causes the development of chronic obstructive pulmonary disease through the integration of multiple pathogenic mechanisms., PMID:33605487
Low HDL concentration in rs2048327-G carriers can predispose men to develop coronary heart disease: Tehran Cardiometabolic genetic study (TCGS)., PMID:33581269
Network mapping of primary CD34+ cells by Ampliseq based whole transcriptome targeted resequencing identifies unexplored differentiation regulatory relationships., PMID:33544756
Induction of aryl hydrocarbon receptor in granulosa cells by endoplasmic reticulum stress contributes to pathology of polycystic ovary syndrome., PMID:33493289
Identification of HIF-dependent alternative splicing in gastrointestinal cancers and characterization of a long, coding isoform of SLC35A3., PMID:33418078
For research use only. Not for human or drug use.
