Catalog No.
YHD71301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Ile531
Predicted molecular weight
59.53 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P26599
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PTB, Polypyrimidine tract-binding protein 1, 57 kDa RNA-binding protein PPTB-1, PTBP1, Heterogeneous nuclear ribonucleoprotein I, hnRNP I
PTBP1 acts as a tumor suppressor in glioma by promoting HMOX1-dependent ferroptosis., PMID:40484043
Efficient synchronization of high expression and site-specific biotinylation of the PTBP1 RRM3/4 domain., PMID:40482899
The Splicing Factor PTBP1 interacts with RUNX1 and is Required for Leukemia Cell Survival., PMID:40475655
Polypyrimidine tract binding proteins PTBP1 and PTBP2 associate with distinct proteins and have distinct post-translational modifications in neuronal nuclear extract., PMID:40465779
Identification of Key Genes and Potential Therapeutic Targets in Sepsis-Associated Acute Kidney Injury Using Transformer and Machine Learning Approaches., PMID:40428155
Long non-coding RNAs plasmacytoma variant translocation 1 regulates bone marrow mesenchymal stem cell transplantation to promote the repair of spinal cord injury., PMID:40418262
miR-124/PTBP1/PKM axis modulates pulmonary artery endothelial metabolism in a pulmonary thromboembolism rat model., PMID:40400966
Review of roles of RNA-binding proteins on NAFLD and the related pharmaceutical measures., PMID:40392981
Firre facilitates myocardial repair by inducing cardiomyocyte cell cycle activity through PTBP1 binding and Akt activation., PMID:40378620
Depletion of Polypyrimidine tract binding protein 1 (ptbp1) activates Müller glia-derived proliferation during zebrafish retina regeneration via modulation of the senescence secretome., PMID:40355064
Transcriptome analysis reveals PTBP1 as a key regulator of circRNA biogenesis., PMID:40350413
Splicing factor PTBP1 promotes hepatocarcinogenesis via oncogenic splice-switching of MAPT., PMID:40296916
The impact of an RNA-binding protein group on regulating the RSPO-LGR4/5-ZNRF3/RNF43 module and the immune microenvironment in hepatocellular carcinoma., PMID:40264052
Mechanical control of the alternative splicing factor PTBP1 regulates extracellular matrix stiffness induced proliferation and cell spreading., PMID:40241749
ATXN2L primarily interacts with NUFIP2, the absence of ATXN2L results in NUFIP2 depletion, and the ATXN2-polyQ expansion triggers NUFIP2 accumulation., PMID:40220918
An HRL-SC/HIF-1α positive feedback loop enhances cell proliferation, migration and angiogenesis in dental pulp stem cells via PI3K/AKT signalling pathway., PMID:40152548
LincRNA-ASAO promotes dental pulp repair through interacting with PTBP1 to increase ALPL alternative splicing., PMID:40140936
PTBP2 promotes cell survival and autophagy in chronic myeloid leukemia by stabilizing BNIP3., PMID:40113750
Landscape of chimeric RNAs in COVID-19 patient blood., PMID:40110491
LINC00942 Accelerates Esophageal Cancer Progression by Raising PRKDC Through Interaction With PTBP1., PMID:40103322
SLC7A5/E2F1/PTBP1/PKM2 axis mediates progression and therapy effect of triple-negative breast cancer through the crosstalk of amino acid metabolism and glycolysis pathway., PMID:40054655
Hsa_circ_0001756 drives gastric cancer glycolysis by increasing the expression and stability of PGK1 mRNA., PMID:40051638
Dengue Virus Life Cycle and Host Protein Interactions: Focus on RNA Binding Proteins and Therapeutic Advances., PMID:40050049
The up-regulation of PTBP1 expression level in patients with Insomnia by senile dementia and promote cuproptosis of nerve cell by SLC31A1., PMID:39985973
Molecular Subtype Identification and Potential Drug Prediction Based on Anoikis-Related Genes Expression in Keratoconus., PMID:39898909
Positive Feedback Regulation between KLF5 and XPO1 Promotes Cell Cycle Progression of Basal like Breast Cancer., PMID:39888288
LncRNA SNHG5 induces CAFs-like phenotype and autophagy of AML-MSCs via PTBP1/ATG5 axis to confer chemoresistance of AML cells., PMID:39864537
CircXYLT1 suppresses oxidative stress and promotes vascular remodeling in aging mice carotid artery injury model of atherosclerosis via PTBP1., PMID:39863188
Transcriptome-wide alternative mRNA splicing analysis reveals post-transcriptional regulation of neuronal differentiation., PMID:39853922
HnRNPM modulates alternative splicing in germ cells by recruiting PTBP1., PMID:39780247
Exploration of Key Regulatory Factors in Mesenchymal Stem Cell Continuous Osteogenic Differentiation via Transcriptomic Analysis., PMID:39766835
N6-methyladenosine modification of 3'tRF-AlaAGC impairs PD-1 blockade efficacy by promoting lactic acid accumulation in the tumor microenvironment of gastric carcinoma., PMID:39752904
PIM1 instigates endothelial-to-mesenchymal transition to aggravate atherosclerosis., PMID:39744686
Base editing of Ptbp1 in neurons alleviates symptoms in a mouse model of Parkinson's disease., PMID:39714464
Exosomes containing circSCP2 in colorectal cancer promote metastasis via sponging miR-92a-1-5p and interacting with PTBP1 to stabilize IGF2BP1., PMID:39702234
Alternative Splicing in the Heart: The Therapeutic Potential of Regulating the Regulators., PMID:39684734
Controversies and insights into PTBP1-related astrocyte-neuron transdifferentiation: neuronal regeneration strategies for Parkinson's and Alzheimer's disease., PMID:39627843
Pan-Cancer Analysis of PTBP1 to Identify it as a Prognostic and Immunological Biomarker., PMID:39612472
CircHipk3 serves a dual role in macrophage pyroptosis by promoting NLRP3 transcription and inhibition of autophagy to induce abdominal aortic aneurysm formation., PMID:39601144
Exosomal long non-coding RNA-LINC00839 promotes lung adenocarcinoma progression by activating NF-κB signaling pathway., PMID:39582330
PTBP1 Lactylation Promotes Glioma Stem Cell Maintenance through PFKFB4-Driven Glycolysis., PMID:39570804
MiR-10b-5p attenuates spinal cord injury and alleviates LPS-induced PC12 cells injury by inhibiting TGF-β1 decay and activating TGF-β1/Smad3 pathway through PTBP1., PMID:39558432
Cell-Type-Specific Splicing of Transcription Regulators and Ptbp1 by Rbfox1/2/3 in the Developing Neocortex., PMID:39532536
PTBP1 crotonylation promotes colorectal cancer progression through alternative splicing-mediated upregulation of the PKM2 gene., PMID:39497094
Hypoxia-driven M2-polarized macrophages facilitate the epithelial-mesenchymal transition of glioblastoma via extracellular vesicles., PMID:39431006
The lncRNA TPTEP1 suppresses PI3K/AKT signalling and inhibits ovarian cancer progression by interacting with PTBP1., PMID:39422584
LINE1 modulate human T cell function by regulating protein synthesis during the life span., PMID:39383231
PTBP1 mediates Sertoli cell actin cytoskeleton organization by regulating alternative splicing of actin regulators., PMID:39373517
LncRNA H19 promoted alcohol-associated liver disease through dysregulation of alternative splicing and methionine metabolism., PMID:39364651
Cell-type-specific splicing of transcription regulators and Ptbp1 by Rbfox1/2/3 in the developing neocortex., PMID:39314274
For research use only. Not for human or drug use.
