Catalog No.
YHD67801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu115-Ile331
Predicted molecular weight
26.29 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P25774
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CTSS, Cathepsin S
IRF8-Cathepsin S/PAR2 axis-mediated spinal microglia-neuron crosstalk is responsible for the exacerbation of postsurgical pain induced by preoperative stress., PMID:40482455
Novel Insights Into the Dynamic Conformational Transitions and Active Site Plasticity of Human Immunoregulatory Cathepsin S., PMID:40418096
Targeting interferon regulatory factor 7 alleviates renal fibrosis by inhibiting macrophage-to-myofibroblast transition., PMID:40412608
TFE3-mediated lysosomal biogenesis and homeostasis alleviates arsenic-induced lysosomal and immune dysfunction in macrophages., PMID:40409189
Genetic and functional validation of CTSS in regulating intramuscular fat content of Duroc-Landrace-Yorkshire pigs., PMID:40251967
Transcriptomic profiling of autophagy and apoptosis pathways in liver cancer cells treated with a new tyrosine kinase inhibitor PD161570., PMID:40242947
Cathepsin S: A key drug target and signalling hub in immune system diseases., PMID:40220622
A Correlational Study between Chest Computed Tomography Severity Score and Laboratory Biomarker among COVID-19 Patient Admitted to a Tertiary Care Institute in a Tribal Belt of Central India., PMID:40214317
Identification of Pivotal ceRNA Networks Associated with Stanford-A Aortic Dissection via Integrated Bioinformatics Analysis., PMID:40123810
Metabolomics- and Proteomics-Based Disease Diagnostic Classifier Model for the Prediction and Diagnosis of Colorectal Carcinoma., PMID:40108892
Elevated circulating cathepsin S levels are associated with cognitive decline and neurodegeneration in a cohort of patients reporting memory complaints., PMID:40095668
Bioinformatics-based identification of CTSS, DOK2, and ENTPD1 as potential blood biomarkers of schizophrenia., PMID:39972407
Proteomic and metabolomic profiling reveals the underlying molecular mechanisms in modified alternate-day fasting-mediated protection against Diabetic kidney disease., PMID:39964999
Molecular Profiling of Odontoclasts during Physiological Tooth Replacement., PMID:39876039
Altered lipid homeostasis and autophagy precipitate diffuse alveolar hemorrhage in murine lupus., PMID:39871963
Activity of Various Cathepsin Proteases and Enrichment of Klotho Protein in the Urine and Urinary Extracellular Vesicles After SARS-CoV-2 Infection., PMID:39861814
The algebraic extended atom-type graph-based model for precise ligand-receptor binding affinity prediction., PMID:39844277
Dual role of Cathepsin S in cutaneous melanoma: insights from mendelian randomization and bioinformatics analysis., PMID:39833734
Integrative genetics and multiomics analysis reveal mechanisms and therapeutic targets in vitiligo highlighting JAK STAT pathway regulation of CTSS., PMID:39824912
Sensitive and Deep Coverage Phosphoproteome Detection Method Reveals Spleen as a More Sensitive Organ than Liver in Early Detection of Liver Fibrosis-Related Signaling Protein Dysregulation., PMID:39823565
Diagnostic potential of blood-based biomarkers in multiple sclerosis., PMID:39811453
Identification of New Polyacetylenes from Dendropanax morbifera with PPAR-α Activity Study., PMID:39770031
Defective removal of invariant chain peptides from MHC class II suppresses tumor antigen presentation and promotes tumor growth., PMID:39752250
A randomized, double-blind, placebo-controlled, multiple dose, parallel study to investigate the effects of a cathepsin S inhibitor in celiac disease., PMID:39739628
[Donor DNA Modification with Cas9 Targeting Sites Improves the Efficiency of MTC34 Knock-in into the CXCR4 Locus]., PMID:39709563
Systematic proteome-wide Mendelian randomization to prioritize causal plasma proteins for skin cancers., PMID:39702585
Benzydamine attenuates microglia-mediated neuroinflammation and ischemic brain injury by targeting cathepsin s., PMID:39700961
Multi-targeted olink proteomics analyses of cerebrospinal fluid from patients with aneurysmal subarachnoid hemorrhage., PMID:39604965
The role of integrin-related genes in atherosclerosis complicated by abdominal aortic aneurysm., PMID:39560590
Cefadroxil Targeting of SLC15A2/PEPT2 Protects From Colistin Nephrotoxicity., PMID:39522761
Biomarkers associated with papillary thyroid carcinoma and Hashimoto's thyroiditis: Bioinformatic analysis and experimental validation., PMID:39510033
The critical involvement of monocytes/macrophages in the pathogenesis of primary Sjögren's syndrome: New evidence from Mendelian randomization and single-cell sequencing., PMID:39497977
Use of mendelian randomization to assess the causal associations of circulating plasma proteins with 12-lead ECG parameters., PMID:39486179
Neuronal cathepsin S increases neuroinflammation and causes cognitive decline via CX3CL1-CX3CR1 axis and JAK2-STAT3 pathway in aging and Alzheimer's disease., PMID:39453382
Shaoyao decoction alleviates DSS-induced colitis by inhibiting IL-17a-mediated polarization of M1 macrophages., PMID:39427735
Exploring the hub Genes and Potential Mechanisms of Complement system-related Genes in Parkinson Disease: Based on Transcriptome Sequencing and Mendelian Randomization., PMID:39373800
Identification and validation of hub differential genes in pulmonary sarcoidosis., PMID:39364409
Cytokine priming enhances the antifibrotic effects of human adipose derived mesenchymal stromal cells conditioned medium., PMID:39334258
Phosphorylation of BRCA1 at serine 1387 plays a critical role in cathepsin S-mediated radiation resistance via BRCA1 degradation and BCL2 stabilization., PMID:39332782
Immunohistochemical Evaluation of Cathepsin B, L, and S Expression in Breast Cancer Patients., PMID:39331316
The PDIA3-STAT3 protein complex regulates IBS formation and development via CTSS/MHC-II pathway-mediated intestinal inflammation., PMID:39286134
Pyrocurzerenone suppresses human oral cancer cell metastasis by inhibiting the expression of ERK1/2 and cathepsin S proteins., PMID:39159189
CD8 + T-cell deficiency protects mice from abdominal aortic aneurysm formation in response to calcium chloride 2., PMID:39146540
Effects of different combinations of mechanical loading intensity, duration, and frequency on the articular cartilage in mice., PMID:39073659
Effects of fasudil on glial cell activation induced by tooth movement., PMID:39034361
Combining network pharmacology and experimental verification to study the anti-colon cancer effect and mechanism of sulforaphene., PMID:39023003
Inhibition of Cathepsin S in Autoimmune CD25KO Mouse Improves Sjögren Disease-Like Lacrimal Gland Pathology., PMID:39017634
Multicenter proteome-wide Mendelian randomization study identifies causal plasma proteins in melanoma and non-melanoma skin cancers., PMID:39003418
Tofacitinib Regulates Endostatin via Effects on CD147 and Cathepsin S., PMID:39000375
A Short Sequence Targets Transmembrane Proteins to Primary Cilia., PMID:38995007
For research use only. Not for human or drug use.
