Catalog No.
YHD66301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser42-Thr102
Predicted molecular weight
33.91 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P25116
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Proteinase-activated receptor 1, PAR-1, PAR1, CF2R, Coagulation factor II receptor, Thrombin receptor, F2R, TR
POLR1F promotes proliferation and stemness of anaplastic thyroid cancer by activating F2R/p38 MAPK signaling., PMID:40250711
Neutrophil-derived serine proteases induce FOXA2-mediated autophagy dysfunction and exacerbate colitis-associated carcinogenesis via protease activated receptor 2., PMID:40205686
Understanding psoriatic disease at single-cell resolution: an update., PMID:40160177
Identification of glucocorticoid-related genes in systemic lupus erythematosus using bioinformatics analysis and machine learning., PMID:40131879
Dual inhibition of canonical and noncanonical PAR-1 by SCH79797 mitigates neurodegeneration in 3-NP-induced Huntington's disease: An in vivo and in silico approach., PMID:40123421
Expression of the Niemann-Pick C1-like 1 Protein in Gastric Cancer., PMID:40037881
Identification and Validation of a Novel Prognostic Signature of Gastric Cancer Based on Seven Complement System-Related Genes: An Integrated Analysis., PMID:39964966
[Analysis of Genes Related to Platelet Activation in Essential Thrombocythemia Based on Transcriptomics]., PMID:39743270
USP34 regulates endothelial PAR1 mRNA transcript expression and cellular signaling., PMID:39705380
Activation of PAR1 contributes to ferroptosis of Schwann cells and inhibits regeneration of myelin sheath after sciatic nerve crush injury in rats via Hippo-YAP/ACSL4 pathway., PMID:39542339
[Optimization and identification of potential targets of obacunone against sepsis]., PMID:39238407
Elucidating PAR1 as a therapeutic target for delayed traumatic brain injury: Unveiling the PPAR-γ/Nrf2/HO-1/GPX4 axis to suppress ferroptosis and alleviate NLRP3 inflammasome activation in rats., PMID:39067398
STING Contributes to Pulmonary Hypertension by Targeting IFN and BMPR2 Signaling through Regulating of F2RL3., PMID:38864771
The mechanism of polyphyllin in the treatment of gastric cancer was verified based on network pharmacology and experimental validation., PMID:38831826
GNB4 Silencing Promotes Pyroptosis to Inhibit the Development of Glioma by Activating cGAS-STING Pathway., PMID:38814382
F2RL3 Regulates Epithelial-Mesenchymal Transition and Angiogenesis in Gastric Cancer through the Rap1/MAPK Signaling Pathway., PMID:38812308
[Mechanism and compatibility efficacy of Astragali Radix-Chuanxiong Rhizoma drug pair in treating ischemic stroke based on network regulation]., PMID:38812133
Network pharmacology prediction and molecular docking-based strategy to explore the potential mechanism of squalene against inflammation., PMID:38756678
Ferrostatin 1 ameliorates UVB-induced damage of HaCaT cells by regulating ferroptosis., PMID:38414007
GPX3-Mediated Oxidative Stress Affects Pyrimidine Metabolism Levels in Stomach Adenocarcinoma via the AMPK/mTOR Pathway., PMID:38322113
Bioinformatics analysis identifies coagulation factor II receptor as a potential biomarker in stomach adenocarcinoma., PMID:38291086
Leukocyte differential gene expression prognostic value for high versus low seizure frequency in temporal lobe epilepsy., PMID:38166692
Targeting class A GPCRs for hard tissue regeneration., PMID:38100905
Plasma protein signatures for high on-treatment platelet reactivity to aspirin and clopidogrel in peripheral artery disease., PMID:37708596
Dysfunction of autophagy in high-fat diet-induced non-alcoholic fatty liver disease., PMID:37700498
Notoginsenoside R1 can inhibit the interaction between FGF1 and VEGFA to retard podocyte apoptosis., PMID:37415174
Heterogeneity of T cells in periapical lesions and in vitro validation of the proangiogenic effect of GZMA on HUVECs., PMID:37400946
Purification and characterization of a serine protease from organic dust and elucidation of its inductive effects on lung inflammatory mediators., PMID:37253661
Identification and validation of immune-related biomarkers and potential regulators and therapeutic targets for diabetic kidney disease., PMID:37127580
Integrated LC-MS/MS and network pharmacology approach for predictingactive ingredients and pharmacological mechanisms of Tribulus terrestris L. against cardiac diseases., PMID:37042962
DNA methylation profiling reveals novel pathway implicated in cardiovascular diseases of diabetes., PMID:36875456
TRAP-induced PAR1 expression with its mechanism during AMI in a rat model., PMID:36809978
Long non-coding RNA ncRuPAR regulates gastric cancer cell proliferation and apoptosis via phosphoinositide 3-kinase/protein kinase B signaling., PMID:36438913
Aspirin Inhibits the Inflammatory Response of Protease-Activated Receptor 1 in Pregnancy Neutrophils: Implications for Treating Women with Preeclampsia., PMID:36362006
PAR2 promotes tumor-associated angiogenesis in lung adenocarcinoma through activating EGFR pathway., PMID:36148733
Identifying the focuses of hereditary gingival fibromatosis with bioinformatics strategies., PMID:35836867
A prognostic risk model for ovarian cancer based on gene expression profiles from gene expression omnibus database., PMID:35761155
Evaluation of photoreceptor-directed fibroblasts derived from retinitis pigmentosa patients with defects in the EYS gene: a possible cost-effective cellular model for mechanism-oriented drug., PMID:35410372
Heterogeneity induced GZMA-F2R communication inefficient impairs antitumor immunotherapy of PD-1 mAb through JAK2/STAT1 signal suppression in hepatocellular carcinoma., PMID:35256589
Epigenetic Regulation of F2RL3 Associates With Myocardial Infarction and Platelet Function., PMID:35012325
Epigenome-wide meta-analysis of PTSD symptom severity in three military cohorts implicates DNA methylation changes in genes involved in immune system and oxidative stress., PMID:34992238
Associations of CYP2C19 and F2R genetic polymorphisms with platelet reactivity in Chinese ischemic stroke patients receiving clopidogrel therapy., PMID:34954768
Amyloid β protein negatively regulates human platelet activation induced by thrombin receptor-activating protein., PMID:34849571
Coagulation Factor Xa Induces Proinflammatory Responses in Cardiac Fibroblasts via Activation of Protease-Activated Receptor-1., PMID:34831181
Whole-Transcriptome Analysis of Yak and Cattle Heart Tissues Reveals Regulatory Pathways Associated With High-Altitude Adaptation., PMID:34093634
Syndecan-1 Promotes Angiogenesis in Triple-Negative Breast Cancer through the Prognostically Relevant Tissue Factor Pathway and Additional Angiogenic Routes., PMID:34066023
α-Arrestin ARRDC3 tumor suppressor function is linked to GPCR-induced TAZ activation and breast cancer metastasis., PMID:33722977
Teprenone ameliorates diclofenac-induced small intestinal injury via inhibiting protease activated receptors 1 and 2 activity., PMID:33176506
F2R Polymorphisms and Clopidogrel Efficacy and Safety in Patients With Minor Stroke or TIA., PMID:33093222
Combined targeting of G protein-coupled receptor and EGF receptor signaling overcomes resistance to PI3K pathway inhibitors in PTEN-null triple negative breast cancer., PMID:32672423
For research use only. Not for human or drug use.
