Catalog No.
YHD66201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu273-Lys362
Predicted molecular weight
12.75 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P25106
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CXCR-7, RDC1, C-X-C chemokine receptor type 7, RDC-1, Chemokine orphan receptor 1, G-protein coupled receptor 159, Atypical chemokine receptor 3, CMKOR1, CXCR7, GPR159, G-protein coupled receptor RDC1 homolog, ACKR3, CXC-R7
Triazole-quinoxaline attenuates epithelial-to-mesenchymal transition by suppressing the Wnt/β-catenin pathway in human colorectal cancer cells., PMID:40414329
Distinct activation mechanisms of CXCR4 and ACKR3 revealed by single-molecule analysis of their conformational landscapes., PMID:40232828
Structural visualization of small molecule recognition by CXCR3 uncovers dual-agonism in the CXCR3-CXCR7 system., PMID:40155369
A patent review of CXCR7 modulators (2019-present)., PMID:40122070
Targeting the CXCR7 pathway with TC14012 to inhibit endothelial necroptosis and lung cancer metastasis., PMID:40049294
Regulation of the chemokine receptors CXCR4 and ACKR3 by receptor activity-modifying proteins., PMID:39662834
ACKR3 in Skin Homeostasis, an Overlooked Player in the CXCR4/CXCL12 Axis., PMID:39466217
Hemin-induced platelet activation is regulated by the ACKR3 chemokine surface receptor and has implications for passivation of vulnerable atherosclerotic plaques., PMID:39387619
ACKR3 agonism induces heterodimerization with chemokine receptor CXCR4 and attenuates platelet function., PMID:39373210
Heterogeneous expression of the atypical chemokine receptor ACKR3 in glioblastoma patient-derived tissue samples and cell cultures., PMID:39300240
CXCR7 genetic variant predicts treatment response of pegylated-interferon α in HBeAg-positive chronic hepatitis B patients., PMID:39265656
Novel Small-Molecule Atypical Chemokine Receptor 3 Agonists: Design, Synthesis, and Pharmacological Evaluation for Antiplatelet Therapy., PMID:39116445
Macrophage Migration Inhibitory Factor (MIF) Upregulates CXCR7 and Contributes to Chemotherapy Resistance in Colorectal Cancer., PMID:39018005
Conformational dynamics underlying atypical chemokine receptor 3 activation., PMID:39008676
Crosstalk between CXCL12/CXCR4/ACKR3 and the STAT3 Pathway., PMID:38920657
CXCR7 activation evokes the anti-PD-L1 antibody against glioblastoma by remodeling CXCL12-mediated immunity., PMID:38898023
Structural basis for selectivity and antagonism in extracellular GPCR-nanobodies., PMID:38816420
Protective Effect of CXCR7 Against Hypoxia/Reoxygenation Injury in Renal Tubular Epithelial Cells., PMID:38806964
Bilayer lipids modulate ligand binding to atypical chemokine receptor 3., PMID:38776922
Multiplex Detection of Fluorescent Chemokine Binding to CXC Chemokine Receptors by NanoBRET., PMID:38732237
Crosstalk between purinergic receptor P2Y11 and chemokine receptor CXCR7 is regulated by CXCR4 in human macrophages., PMID:38472446
Regulation of the Hippo/YAP axis by CXCR7 in the tumorigenesis of gastric cancer., PMID:37950281
CXCL12-CXCR4/CXCR7 Axis in Cancer: from Mechanisms to Clinical Applications., PMID:37497001
Atypical Chemokine Receptor 3 "Senses" CXC Chemokine Receptor 4 Activation Through GPCR Kinase Phosphorylation., PMID:37474305
Reassessing the adrenomedullin scavenging function of ACKR3 in lymphatic endothelial cells., PMID:37252916
CXCR7 as a novel therapeutic target for advanced prostate cancer., PMID:36755058
ACKR3 promotes CXCL12/CXCR4-mediated cell-to-cell-induced lymphoma migration through LTB4 production., PMID:36713377
CXCR4-CXCL12-CXCR7 and PD-1/PD-L1 in Pancreatic Cancer: CXCL12 Predicts Survival of Radically Resected Patients., PMID:36359736
Crosstalk between CXCR4/ACKR3 and EGFR Signaling in Breast Cancer Cells., PMID:36233192
Discovery and Development of First-in-Class ACKR3/CXCR7 Superagonists for Platelet Degranulation Modulation., PMID:36150079
Structural snapshot of a β-arrestin-biased receptor., PMID:36057461
Low Expression Levels of CXCL12, CXCR4, and CXCR 7 in Peripheral Blood and Decidual Tissues are Associated with Miscarriage in Women., PMID:35912820
Conformational selection guides β-arrestin recruitment at a biased G protein-coupled receptor., PMID:35857540
Emerging Roles of the Atypical Chemokine Receptor 3 (ACKR3) in Cardiovascular Diseases., PMID:35846294
Ursolic acid inhibits proliferation, migration and invasion of human papillary thyroid carcinoma cells via CXCL12/CXCR4/CXCR7 axis through cancer-associated fibroblasts., PMID:35786050
Selective Elimination of Senescent Fibroblasts by Targeting the Cell Surface Protein ACKR3., PMID:35742971
The CXCL12/CXCR4/ACKR3 Signaling Axis Regulates PKM2 and Glycolysis., PMID:35681470
[Effect of CXC chemokine receptor 7 on cell cycle of neuronal cells in ischemic stroke]., PMID:35387720
C-X-C motif chemokine ligand 12 (CXCL12)/C-X-C motif chemokine receptor 7(CXCR7) regulates epithelial-mesenchymal transition process and promotes the metastasis of esophageal cancer by activating signal transducer and activator of transcription 3 (STAT3) pathway., PMID:35264069
MicroRNA-200b-3p restrains gastric cancer cell proliferation, migration, and invasion via C-X-C motif chemokine ligand 12/CXC chemokine receptor 7 axis., PMID:35226830
Interactions of selected cardiovascular active natural compounds with CXCR4 and CXCR7 receptors: a molecular docking, molecular dynamics, and pharmacokinetic/toxicity prediction study., PMID:35120520
C‑X‑C receptor 7 agonist acts as a C‑X‑C motif chemokine ligand 12 inhibitor to ameliorate osteoclastogenesis and bone resorption., PMID:35014674
Decursin inhibits tumor progression in head and neck squamous cell carcinoma by downregulating CXCR7 expression in vitro., PMID:34958113
CXCR4 and CXCR7 Inhibition Ameliorates the Formation of Platelet-Neutrophil Complexes and Neutrophil Extracellular Traps through Adora2b Signaling., PMID:34948374
Prognostic significance of SDF-1 chemokine and its receptors CXCR4 and CXCR7 involved in EMT of prostate cancer., PMID:34920230
Platelet ACKR3/CXCR7 favors antiplatelet lipids over an atherothrombotic lipidome and regulates thromboinflammation., PMID:34905596
Target engagement of the first-in-class CXCR7 antagonist ACT-1004-1239 following multiple-dose administration in mice and humans., PMID:34794236
Changes in DNA methylation in APOE and ACKR3 genes in multiple sclerosis patients and the relationship with their heavy metal blood levels., PMID:34624384
Expression of CXCR4 and CXCR7 in papillary thyroid carcinoma and adjacent tissues and their relationship with pathologic indicators of tumor aggressiveness., PMID:34588386
Ackr3-Venus knock-in mouse lights up brain vasculature., PMID:34583741
For research use only. Not for human or drug use.
