Catalog No.
RHH86402
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Applications
IHC, IP, WB
Recommended Dilution
| Application |
Dilution |
| IHC |
1:100-1:200, IP: 1:100-1:200, WB: 1:500-1:1000 |
Target
PDCD4, Neoplastic transformation inhibitor protein, Nuclear antigen H731-like, Protein 197/15a, H731, Programmed cell death protein 4
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q53EL6
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3U84
Note
For research use only.
Novel human PDCD4 (H731) gene expressed in proliferative cells is expressed in the small duct epithelial cells of the breast as revealed by an anti-H731 antibody., PMID:10632927
Programmed cell death-4 tumor suppressor protein contributes to retinoic acid-induced terminal granulocytic differentiation of human myeloid leukemia cells., PMID:17259349
Alterations in the expression of PDCD4 in ductal carcinoma of the breast., PMID:17982621
[Expression of PD4, CD44v6, CD44v9 and its clinical significance in human laryngeal carcinoma]., PMID:18476625
Development of LanthaScreen cellular assays for key components within the PI3K/AKT/mTOR pathway., PMID:19196698
Hyaluronan-CD44 interaction with protein kinase C(epsilon) promotes oncogenic signaling by the stem cell marker Nanog and the Production of microRNA-21, leading to down-regulation of the tumor suppressor protein PDCD4, anti-apoptosis, and chemotherapy resistance in breast tumor cells., PMID:19633292
Micro-RNA-21 regulates TGF-β-induced myofibroblast differentiation by targeting PDCD4 in tumor-stroma interaction., PMID:20533548
Pdcd4 expression in intraductal papillary mucinous neoplasm of the pancreas: its association with tumor progression and proliferation., PMID:20656320
[The expression of PD4 and its significance in human laryngeal carcinoma]., PMID:21809556
A polymorphism affecting MYB binding within the promoter of the PDCD4 gene is associated with severe asthma in children., PMID:23606399
AC1MMYR2, an inhibitor of dicer-mediated biogenesis of Oncomir miR-21, reverses epithelial-mesenchymal transition and suppresses tumor growth and progression., PMID:23811941
Epstein-Barr Virus_Encoded LMP1 upregulates microRNA-21 to promote the resistance of nasopharyngeal carcinoma cells to cisplatin-induced Apoptosis by suppressing PDCD4 and Fas-L., PMID:24194922
Inhibiting CARD11 translation during BCR activation by targeting the eIF4A RNA helicase., PMID:25320244
Deficiency of programmed cell death 4 results in increased IL-10 expression by macrophages and thereby attenuates atherosclerosis in hyperlipidemic mice., PMID:26166769
MicroRNA-21 links epithelial-to-mesenchymal transition and inflammatory signals to confer resistance to neoadjuvant trastuzumab and chemotherapy in HER2-positive breast cancer patients., PMID:26452030
Engagement of the B-cell receptor of chronic lymphocytic leukemia cells drives global and MYC-specific mRNA translation., PMID:26491071
Developing anti-neoplastic biotherapeutics against eIF4F., PMID:28004147
Co-delivery of microRNA-21 antisense oligonucleotides and gemcitabine using nanomedicine for pancreatic cancer therapy., PMID:28444967
Identification of a TLR2-regulated gene signature associated with tumor cell growth in gastric cancer., PMID:28481875
CTLA-4-mediated posttranslational modifications direct cytotoxic T-lymphocyte differentiation., PMID:28644433
Suppressors for Human Epidermal Growth Factor Receptor 2/4 (HER2/4): A New Family of Anti-Toxoplasmic Agents in ARPE-19 Cells., PMID:29103264
Activation of miR-21-Regulated Pathways in Immune Aging Selects against Signatures Characteristic of Memory T Cells., PMID:30463012
Degradation of the Tumor Suppressor PDCD4 Is Impaired by the Suppression of p62/SQSTM1 and Autophagy., PMID:31952347
MicroRNA-183-5p is stress-inducible and protects neurons against cell death in amyotrophic lateral sclerosis., PMID:32558113
Targeted inhibition of eIF4A suppresses B-cell receptor-induced translation and expression of MYC and MCL1 in chronic lymphocytic leukemia cells., PMID:34398253
Anti-PD-L1 Antibody Enhances T Cell Immune Responses and Reduces Resistance of Breast Cancer Cells to Radiotherapy., PMID:35295718
B-cell receptor signaling induces proteasomal degradation of PDCD4 via MEK1/2 and mTORC1 in malignant B cells., PMID:35306137
An integrated proteome and transcriptome of B cell maturation defines poised activation states of transitional and mature B cells., PMID:37612319
Microglial Pdcd4 deficiency mitigates neuroinflammation-associated depression via facilitating Daxx mediated PPARγ/IL-10 signaling., PMID:38822367
For research use only. Not for human or drug use.
