Catalog No.
YHD64701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Leu298
Predicted molecular weight
36.24 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P24941
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CDK2, p33 protein kinase, Cyclin-dependent kinase 2, CDKN2, Cell division protein kinase 2
TarIKGC: A Target Identification Tool Using Semantics-Enhanced Knowledge Graph Completion with Application to CDK2 Inhibitor Discovery. [YHD64701]
Multifaceted computational insights of murrayacinine as dual inhibitors of CDK2 and MAPK3 to combat cervical cancer., PMID:40513148
Identification of potential human targets for epigallocatechin gallate through a novel protein binding site screening approach., PMID:40512223
Polyphyllin I inhibits ovarian cancer growth by inducing G0/G1 phase arrest and inhibiting the c-Myc signaling pathway., PMID:40506557
Polystyrene microplastics induces the injury of human corneal epithelial cells through ROS-mediated p53 pathway., PMID:40503930
MicroRNA-18b regulates cell cycle progression in papillary thyroid carcinoma by targeting CDK2: an in vitro experimental study., PMID:40503265
The n-butanol extract of Polygonatum sibiricum improves spleen aging via p53 pathway., PMID:40494016
Marine natural product Methyl mycophenolate inhibits gastric cancer growth through regulating p53 and the downstream pathways., PMID:40484944
Gilteritinib suppresses prostate cancer cell proliferation and migration and induces ER stress-mediated non-autophagic cytoplasmic vacuolization cell death., PMID:40481367
Multiscale analysis and optimal glioma therapeutic candidate discovery using the CANDO platform., PMID:40475540
Phosphorylation State of RB Modulates Ferroptotic Sensitivity., PMID:40468563
AMBRA1 Inhibits Non-Small Cell Lung Cancer Progression Through miR-1178/p53/CDK2-Regulated Cell Cycle Arrest., PMID:40464146
Inhibition of tumor-intrinsic NAT10 enhances antitumor immunity by triggering type I interferon response via MYC/CDK2/DNMT1 pathway., PMID:40461504
C1QBP promotes apoptosis of goat fetal turbinate cells via inhibiting the expression of TRIM5 or TNFSF10., PMID:40454173
An overview of isatin-derived CDK2 inhibitors in developing anticancer agents., PMID:40451137
Unveiling Isorhapontigenin's therapeutic potential in lung cancer via integrated network pharmacology, molecular docking, and experimental validation., PMID:40442126
IL-13 May Could Enhance the Proliferation and Affect the Differentiation of Nasal Epithelium Basal Cells Through the mTOR/p70S6K1 Pathway in Chronic Rhinosinusitis With Nasal Polyps., PMID:40438321
Carboxylesterase 1 regulates peroxisome proliferator-activated receptor gamma to inhibit the growth and metastasis of breast cancer cells., PMID:40418235
Limocitrin induced cellular death through ERK pathways in human oral squamous cell cancer., PMID:40404781
Effect of citrus essential oil petit grain in growth and motility reduction of hypopharyngeal squamous cell carcinoma (FaDu) in vitro model., PMID:40397313
Enhancing hepatocellular carcinoma treatment: synergistic cytotoxicity and mechanistic insights of Ramucirumab and 5-Azacytidine combination therapy., PMID:40397219
The Quasi-Bound State as a Predictor of Relative Binding Free Energy., PMID:40392679
Paris saponin VII restrains PD-L1 mediated immune evasion through the AKT1 and STAT3 signaling pathways., PMID:40389195
Dibromo-Edaravone Induces Anti-Erythroleukemia Effects via the JAK2-STAT3 Signaling Pathway., PMID:40362240
Development of Benzothiazole-grafted Pyrazolo[1,5-a]pyrimidines as new CDK2 inhibitors and anti-prostate cancer agents., PMID:40359842
Asarum heterotropoides F. schmidt attenuates osteoarthritis via multi-target anti-inflammatory actions: A network pharmacology and experimental validation., PMID:40345271
lncRNA AK159072 Promotes Myoblast Proliferation and Muscle Regeneration Through Activation of Akt/Foxo1 Pathway., PMID:40341721
Deciphering the mechanism of baicalein in cervical cancer via bioinformatics, machine learning and computational simulations: PIM1 and CDK2 are key target proteins., PMID:40339869
Automated On-the-Fly Optimization of Resource Allocation for Efficient Free Energy Simulations., PMID:40328725
Computational Estimation of Residence Time on Roniciclib and Its Derivatives against CDK2: Extending the Use of Classical and Enhanced Molecular Dynamics Simulations., PMID:40321554
Therapy-induced senescence of glioblastoma cells is determined by the p21CIP1-CDK1/2 axis and does not require activation of DREAM., PMID:40319068
Cell cycle duration determines oncogenic transformation capacity., PMID:40307557
Potent Anti-Cancer Activity of Benzo[d]Thiazole-Isatin Conjugates: Induces S Phase Arrest and Cell Necrosis in A549 and HepG2 Cells., PMID:40304277
SNRPB2: a prognostic biomarker and oncogenic driver in esophageal cancer via β-catenin/c-Myc signaling., PMID:40303992
SH003 Inhibits Proliferation and Induces Apoptosis in Colon Cancer Through the RTK-STAT3 Pathway., PMID:40295067
Naphthalimide derivative attenuates tumor growth of wild-type p53-expressing U87 glioma cells in vitro and in vivo through a biphasic dose-dependent mechanism: A switch from cell cycle to apoptosis., PMID:40294493
Synthesis and Biological Studies of Aurones Derivatives for its Anticancer Potential., PMID:40289977
Mechanistic insights into proteasome inhibitor MG132 induced apoptosis in melanoma A375 cells., PMID:40289224
Caffeine-boosted silver nanoparticles target breast cancer cells by triggering oxidative stress, inflammation, and apoptotic pathways., PMID:40280486
Anticancer potential of novel benzothiazolyl piperidine-3-carboxamide derivatives as CDKs and VEGFR2 multi-target kinase inhibitors., PMID:40278942
Extracts from Allium pseudojaponicum Makino Target STAT3 Signaling Pathway to Overcome Cisplatin Resistance in Lung Cancer., PMID:40278288
Resveratrol inhibits the progression of oral squamouscell carcinoma through Norad/Igf2bp2/Pdk1 pathway and remodeling glucose metabolism reprogramming., PMID:40272637
20(S)-ginsenoside Rg3 suppresses gastric cancer cell proliferation by inhibiting E2F-DP dimerization., PMID:40252583
Role of the cell cycle-related gene cdk2 and its associated ceRNA network in sexual size dimorphism of Cynoglossus semilaevis., PMID:40250729
CDK2 heterobifunctional degraders co-degrade CDK2 and cyclin E resulting in efficacy in CCNE1-amplified and overexpressed cancers., PMID:40250405
Decreased Cdk2 Activity Hindered Embryonic Development and Parthenogenesis Induction in Silkworm, Bombyx mori L., PMID:40244186
Regulatory mimicry of cyclin-dependent kinases by a conserved herpesvirus protein kinase., PMID:40238458
CDK2 inhibition produces a persistent population of polyploid cancer cells., PMID:40232858
Mechanistic Study of Chaga Medicinal Mushroom Inonotus obliquus (Agaricomycetes) Phenolic Compounds in the Treatment of Liver Cancer: A Database and Simulation Approach., PMID:40228216
CHK1 inhibition overcomes gemcitabine resistance in non-small cell lung cancer cell A549., PMID:40226818
Schisandrin B downregulates exosomal fibronectin 1 expression to inhibit hepatocellular carcinoma growth., PMID:40223922
For research use only. Not for human or drug use.
