Catalog No.
RHH28505
Species reactivity
Human, Mouse
Host species
Mouse
Isotype
IgG2a
Clonality
Monoclonal
Applications
ELISA, FCM, WB
Recommended Dilution
| Application |
Dilution |
| ELISA |
1:10000, FCM: 1:200-1:400, WB: 1:500-1:2000 |
Target
CDC37, Hsp90 co-chaperone Cdc37, Hsp90 chaperone protein kinase-targeting subunit, p50Cdc37, CDC37A
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q16543
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3U35
Note
For research use only.
A novel glycosaminoglycan-binding protein is the vertebrate homologue of the cell cycle control protein, Cdc37., PMID:7608185
A 50 kilodalton protein associated with raf and pp60(v-src) protein kinases is a mammalian homolog of the cell cycle control protein cdc37., PMID:9132011
p50(cdc37) is a nonexclusive Hsp90 cohort which participates intimately in Hsp90-mediated folding of immature kinase molecules., PMID:10858314
Molecular characterization of a novel intracellular hyaluronan-binding protein., PMID:10887182
Interaction of Hsp90 with the nascent form of the mutant epidermal growth factor receptor EGFRvIII., PMID:12471035
Identification of transcription coactivator OCA-B-dependent genes involved in antigen-dependent B cell differentiation by cDNA array analyses., PMID:12857960
Effect of single wall carbon nanotubes on human HEK293 cells., PMID:15585362
The platelet-derived growth factor receptor alpha is destabilized by geldanamycins in cancer cells., PMID:17079230
Analysis of the CK2-dependent phosphorylation of serine 13 in Cdc37 using a phospho-specific antibody and phospho-affinity gel electrophoresis., PMID:17922836
Evaluating CK2 activity with the antibody specific for the CK2-phosphorylated form of a kinase-targeting cochaperone Cdc37., PMID:18566753
Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37., PMID:18922470
Split Renilla luciferase protein fragment-assisted complementation (SRL-PFAC) to characterize Hsp90-Cdc37 complex and identify critical residues in protein/protein interactions., PMID:20413594
Constitutively active Lck kinase in T cells drives antigen receptor signal transduction., PMID:20541955
Serum IgG responses against Aspergillus proteins before hematopoietic stem cell transplantation or chemotherapy identify patients who develop invasive aspergillosis., PMID:22824184
Cell surface Cdc37 participates in extracellular HSP90 mediated cancer cell invasion., PMID:22912728
Hsp90, an unlikely ally in the war on cancer., PMID:23356585
IP-FCM platform detects the existence and regulator-caused dissociation of components in naturally assembled HSP90 complex., PMID:24265268
Protein kinase CK2 inhibition is associated with the destabilization of HIF-1α in human cancer cells., PMID:25449433
Targeting HSF1 disrupts HSP90 chaperone function in chronic lymphocytic leukemia., PMID:26397138
Simultaneous blockade of interacting CK2 and EGFR pathways by tumor-targeting nanobioconjugates increases therapeutic efficacy against glioblastoma multiforme., PMID:27825958
Ganetespib for small cell lung cancer., PMID:27922280
DCZ3112, a novel Hsp90 inhibitor, exerts potent antitumor activity against HER2-positive breast cancer through disruption of Hsp90-Cdc37 interaction., PMID:30017966
SUMOylation Is Required for ERK5 Nuclear Translocation and ERK5-Mediated Cancer Cell Proliferation., PMID:32209980
Th1 cytokine interferon gamma improves response in HER2 breast cancer by modulating the ubiquitin proteasomal pathway., PMID:33412308
Phosphatases maintain low catalytic activity of SGK1: DNA damage resets the balance in favor of phosphorylation., PMID:37343701
Predictive value of CDC37 gene expression for targeted therapy in metastatic colorectal cancer., PMID:38359495
For research use only. Not for human or drug use.
