Anti-GAB1 Antibody (R3S54)

Catalog No.

RHG55102

Species reactivity

Human

Host species

Mouse

Isotype

IgG1

Clonality

Monoclonal

Applications

ELISA, FCM, IHC, WB

Recommended Dilution

Application	Dilution
ELISA	1:10000, FCM: 1:200-1:400, IHC: 1:200-1:1000, WB: 1:500-1:2000

Target

GRB2-associated binder 1, Growth factor receptor bound protein 2-associated protein 1, GAB1, GRB2-associated-binding protein 1

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q13480

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% Sodium Azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

R3S54

Note

For research use only.

Crk synergizes with epidermal growth factor for epithelial invasion and morphogenesis and is required for the met morphogenic program., PMID:12138161

Evidence for a role of platelet endothelial cell adhesion molecule-1 in endothelial cell mechanosignal transduction: is it a mechanoresponsive molecule?, PMID:12177047

Non-T cell activation linker (NTAL): a transmembrane adaptor protein involved in immunoreceptor signaling., PMID:12486104

Gab3-deficient mice exhibit normal development and hematopoiesis and are immunocompetent., PMID:12640125

GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2., PMID:12819203

Noonan syndrome-associated SHP2/PTPN11 mutants cause EGF-dependent prolonged GAB1 binding and sustained ERK2/MAPK1 activation., PMID:14974085

Blockade of epidermal growth factor- or heregulin-dependent ErbB2 activation with the anti-ErbB2 monoclonal antibody 2C4 has divergent downstream signaling and growth effects., PMID:15059917

The absence of Grb2-associated binder 2 (Gab2) does not disrupt NK cell development and functions., PMID:15240750

Entire mitogen activated protein kinase (MAPK) pathway is present in preimplantation mouse embryos., PMID:15305288

Six post-implantation lethal knockouts of genes for lipophilic MAPK pathway proteins are expressed in preimplantation mouse embryos and trophoblast stem cells., PMID:15736129

Agonist Met antibodies define the signalling threshold required for a full mitogenic and invasive program of Kaposi's Sarcoma cells., PMID:16039997

The BCR signalosome: where cell fate is decided., PMID:16178270

Role of Per1-interacting protein of the suprachiasmatic nucleus in NGF mediated neuronal survival., PMID:16298334

Cross-talk of WNT and FGF signaling pathways at GSK3beta to regulate beta-catenin and SNAIL signaling cascades., PMID:16940750

c-Met must translocate to the nucleus to initiate calcium signals., PMID:18073207

Immunomodulation of human B cells following treatment with intravenous immunoglobulins involves increased phosphorylation of extracellular signal-regulated kinases 1 and 2., PMID:18689724

Osteoblastic molecular scaffold Gab1 is required for maintaining bone homeostasis., PMID:20124419

Hepatocyte growth factor induces resistance to anti-epidermal growth factor receptor antibody in lung cancer., PMID:22089117

Dual inhibition of Met kinase and angiogenesis to overcome HGF-induced EGFR-TKI resistance in EGFR mutant lung cancer., PMID:22789825

Macroporous hydrogel micropillars for quantifying Met kinase activity in cancer cell lysates., PMID:22814332

KRC-327, a selective novel inhibitor of c-Met receptor tyrosine kinase with anticancer activity., PMID:23340177

Acquired substrate preference for GAB1 protein bestows transforming activity to ERBB2 kinase lung cancer mutants., PMID:23612964

Tyrosine phosphorylation of the orphan receptor ESDN/DCBLD2 serves as a scaffold for the signaling adaptor CrkL., PMID:23770091

miR-150 influences B-cell receptor signaling in chronic lymphocytic leukemia by regulating expression of GAB1 and FOXP1., PMID:24787006

miR in CLL: more than mere markers of prognosis?, PMID:24993874

B-cell receptor signalling and its crosstalk with other pathways in normal and malignant cells., PMID:25080849

Microenvironment-derived HGF overcomes genetically determined sensitivity to anti-MET drugs., PMID:25217525

MicroRNAs in B-cell lymphomas: how a complex biology gets more complex., PMID:25541152

Targeted nanoconjugate co-delivering siRNA and tyrosine kinase inhibitor to KRAS mutant NSCLC dissociates GAB1-SHP2 post oncogene knockdown., PMID:27530552

Molecular Characterization of Striated Muscle-Specific Gab1 Isoform as a Critical Signal Transducer for Neuregulin-1/ErbB Signaling in Cardiomyocytes., PMID:27861634

Uniformity under in vitro conditions: Changes in the phenotype of cancer cell lines derived from different medulloblastoma subgroups., PMID:28231263

Soft tissue angiofibroma: Clinicopathologic, immunohistochemical and molecular analysis of 14 cases., PMID:28639284

Measurement of Epidermal Growth Factor Receptor-Derived Signals Within Plasma Membrane Clathrin Structures., PMID:28791645

Characterization of In Vivo Resistance to Osimertinib and JNJ-61186372, an EGFR/Met Bispecific Antibody, Reveals Unique and Consensus Mechanisms of Resistance., PMID:28830985

Medulloblastoma with myogenic and/or melanotic differentiation does not align immunohistochemically with the genetically defined molecular subgroups., PMID:29412177

Large-Scale Phosphoproteomics Reveals Shp-2 Phosphatase-Dependent Regulators of Pdgf Receptor Signaling., PMID:29514104

Medulloblastoma, WNT-activated/SHH-activated: clinical impact of molecular analysis and histogenetic evaluation., PMID:29582169

Systems analysis of protein signatures predicting cetuximab responses in KRAS, NRAS, BRAF and PIK3CA wild-type patient-derived xenograft models of metastatic colorectal cancer., PMID:32700762

Mechanisms of miR‑128‑3p in inhibiting osteoblast differentiation from bone marrow‑derived mesenchymal stromal cells., PMID:33174052

Diagnostic Accuracy of a Reduced Immunohistochemical Panel in Medulloblastoma Molecular Subtyping, Correlated to DNA-methylation Analysis., PMID:33323893

Medulloblastoma: clinicopathological parameters, risk stratification, and survival analysis of immunohistochemically validated molecular subgroups., PMID:33555447

Subcellular Dynamic Immunopatterning of Cytosolic Protein Complexes on Microstructured Polymer Substrates., PMID:34652152

Anti-c-MET Fab-Grb2-Gab1 Fusion Protein-Mediated Interference of c-MET Signaling Pathway Induces Methuosis in Tumor Cells., PMID:36233320

Clinicomorphological and molecular analysis of medulloblastoma and association with survival: A single tertiary care center experience., PMID:38384024

Network analysis reveals a major role for 14q32 cluster miRNAs in determining transcriptional differences between IGHV-mutated and unmutated CLL., PMID:37169950

Immunohistochemical Surrogates for Molecular Stratification in Medulloblastoma., PMID:37471625

A novel bivalent anti-c-MET/PD-1 bispecific antibody exhibits potent cytotoxicity against c-MET/PD-L1-positive colorectal cancer., PMID:37646958

Dynamic altruistic cooperation within breast tumors., PMID:38093346

[Mechanism of Paeoniae Radix Rubra and Aconiti Lateralis Radix Praeparata herbal pair in promoting hepatocellular regeneration in chronic acute liver failure based on HGF/PI3K/Akt signaling axis]., PMID:39307751

Molecular classification of medulloblastoma using immunohistochemistry: A single centre study., PMID:40056547

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