Catalog No.
YHD59301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser3-Leu161
Predicted molecular weight
20.09 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P23528
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Cofilin, non-muscle isoform, CFL1, p18, 18 kDa phosphoprotein, CFL, Cofilin-1
PKCα Phosphorylates FACI to Switch Its Function in Clathrin-Mediated Endocytosis to a Presumed Role in Macropinocytosis in Intestinal and Hepatic Cells., PMID:40466940
Role of LIMK1-cofilin-actin axis in dendritic spine dynamics in Alzheimer's disease., PMID:40461464
Identification of multiomics and immune infiltration-associated biomarkers for early gastric cancer: a machine learning-based diagnostic model development study., PMID:40450287
Exploring the Mechanisms of Cyclosporine Therapy in Aplastic Anemia: A Data-Independent Acquisition Proteomics Approach., PMID:40439573
Sodium/hydrogen exchanger 8 affects sheet migration of human intestinal epithelial cells (HT29MTX) by influencing the actin cytoskeletal rearrangement., PMID:40434024
Androgen receptor plays critical role in regulating cervical cancer cell migration., PMID:40409531
Proteomic Analysis of Transbronchial Biopsies to Discover Novel Biomarkers for Early Identification of Chronic Lung Allograft Dysfunction., PMID:40371053
IL-9 promotes migratory dissemination of malignant T-cells by activating the HIF-1α-Cofilin-1 axis in cutaneous T-cell lymphoma., PMID:40366351
PTEN inhibits scavenger receptor-mediated phagocytosis of methicillin-resistant Staphylococcus aureus., PMID:40288813
Leucine-Rich Repeat Kinase 1 Signaling Targets Proteins Critical for Endosome/Lysosome Sorting and Trafficking in Osteoclasts., PMID:40282191
Oncogenic β-catenin stimulation of cofilin 1-mediated macropinocytosis is druggable for cancer., PMID:40213667
Gastrodin Mitigates Ketamine-Induced Inhibition of F-Actin Remodeling and Cell Migration by Regulating the Rho Signaling Pathway., PMID:40149625
A high affinity Sybody blocks Cofilin-1 binding to F-actin in vitro and in cancer cells., PMID:40064451
NUDC Is Critical for Mitosis and Postmitotic Cell Maintenance Through Its Modulation of Dynein and Actin Cytoskeletal Reorganization., PMID:39930237
12/15-Lipoxygenase-Derived Electrophilic Lipid Modifications in Phagocytic Macrophages., PMID:39818720
Sodium arsenite induces islets β-cells apoptosis and dysfunction via SET-Rac1-mediated cytoskeleton disturbance., PMID:39765117
Proteomic Analysis of Anticancer Effect of Myo-inositol in Human Prostate Cancer (DU-145) Cell Line., PMID:39733438
Lower expression of MMP2, FLNA, and CFL1 is correlated with favorable prognosis in invasive micropapillary breast cancer., PMID:39724992
Ischemia-induced expression status of cofilin 1, CRSP2, HSP90, HSP27, and IL8 in epicardial adipose tissue and single cell transcriptomic profiling of stromal cells., PMID:39689294
Cytoskeleton Remodeling-Related Proteins Represent a Specific Salivary Signature in PSC Patients., PMID:39683940
Reduced cofilin activity as a mechanism contributing to endothelial cell stiffening in type 2 diabetes., PMID:39611817
Machine Learning Analysis of RNA-Seq Data Identifies Key Gene Signatures and Pathways in Mpox Virus-Induced Gastrointestinal Complications Using Colon Organoid Models., PMID:39456924
Tropisetron, an Antiemetic Drug, Exerts an Anti-Epileptic Effect Through the Activation of α7nAChRs in a Rat Model of Temporal Lobe Epilepsy., PMID:39445711
PTBP1 mediates Sertoli cell actin cytoskeleton organization by regulating alternative splicing of actin regulators., PMID:39373517
Effects of SIPA1L1 on trabecular meshwork extracellular matrix protein accumulation and cellular phagocytosis in POAG., PMID:39361424
F-actin in the cuticular plate and junctions of auditory hair cells is regulated by ADF and cofilin to allow for normal stereocilia bundle patterning and maintenance., PMID:39305224
Ischemic cardiac stromal fibroblast-derived protein mediators in the infarcted myocardium and transcriptomic profiling at single cell resolution., PMID:39302489
Ellman's Assay on the Surface: Thiol Quantification of Human Cofilin-1 Protein through Surface Plasmon Resonance., PMID:39292813
Age-dependent sex differences in cofilin1 pathway (LIMK1/SSH1) and its association with AD biomarkers after chronic systemic inflammation in mice., PMID:39265451
Correlation analysis of cofilin-1 with renal prognosis in primary IgA nephropathy., PMID:39227817
α-Synuclein-mediated mitochondrial translocation of cofilin-1 leads to oxidative stress and cell apoptosis in PD., PMID:39224576
Semaphorin-3A regulates liver sinusoidal endothelial cell porosity and promotes hepatic steatosis., PMID:39196233
Assessment of NB-UVB Effects on Skin of Atopic Dermatitis Patients: A Network Analysis., PMID:39188927
Combining proteomics and Phosphoproteomics to investigate radiation-induced rectal fibrosis in rats and the effects of pSTAT3 inhibitor S3I-201 on human intestinal fibroblasts., PMID:39173903
Sensitization of hepatocellular carcinoma cells to HDACi is regulated through hsa-miR-342-5p/CFL1., PMID:39152428
Single-pericyte nanomechanics measured by contraction cytometry., PMID:39131206
Unraveling genetic threads: Identifying novel therapeutic targets for allergic rhinitis through Mendelian randomization., PMID:39040085
[The expression and prognosis prediction of CFL-1 in head and neck squamous cell carcinoma]., PMID:39005090
Ultrastructural Characterization of PBMCs and Extracellular Vesicles in Multiple Sclerosis: A Pilot Study., PMID:38999977
LIMK1 promotes the development of cervical cancer by up-regulating the ROS/Src-FAK/cofilin signaling pathway., PMID:38975937
Cyclosporine A Protects Podocytes by Regulating Transgelin in Adriamycin-Induced Podocyte Injury., PMID:38952124
[Retracted] Paclitaxel inhibits breast cancer metastasis via suppression of Aurora kinase‑mediated cofilin‑1 activity., PMID:38873044
FLNA regulates neuronal maturation by modulating RAC1-Cofilin activity in the developing cortex., PMID:38852754
Thermostability-assisted limited proteolysis-coupled mass spectrometry for capturing drug target proteins and sites., PMID:38834267
Multicomponent depolymerization of actin filament pointed ends by cofilin and cyclase-associated protein depends upon filament age., PMID:38796920
The interaction of PRDX1 with Cofilin promotes oral squamous cell carcinoma metastasis., PMID:38738971
Impact of siRNA-Mediated Cofilin-1 Knockdown and Obesity Associated Microenvironment on the Motility of Natural Killer Cells., PMID:38721960
The amoeboid migration of monocytes in confining channels requires the local remodeling of the cortical actin cytoskeleton by cofilin-1., PMID:38702365
Deciphering the Cofilin Oligomers via Intermolecular Disulfide Bond Formation: A Coarse-Grained Molecular Dynamics Approach to Understanding Cofilin's Regulation on Actin Filaments., PMID:38701111
Identification of an immune-related gene signature for predicting prognosis and immunotherapy efficacy in liver cancer via cell-cell communication., PMID:38617448
For research use only. Not for human or drug use.
