Catalog No.
YHD58401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu32-Glu189
Predicted molecular weight
20.19 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P23471
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Receptor-type tyrosine-protein phosphatase zeta, R-PTP-zeta, R-PTP-zeta-2, PTPRZ1, PTPRZ, PTPRZ2, PTPZ, HTPZP2, Protein-tyrosine phosphatase receptor type Z polypeptide 2, Protein-tyrosine phosphatase receptor type Z polypeptide 1
Mutational and expression analysis of classical protein tyrosine phosphatase genes in pancreatic ductal adenocarcinoma., PMID:40403635
Regulation of Pleiotrophin and PTPRZ1 Expression by Hypoxia to Restrict Hypoxia-Induced Cell Migration., PMID:40361445
Astrocytic pleiotrophin deficiency in the prefrontal cortex contributes to stress-induced depressive-like responses in male mice., PMID:40087317
Curcumin Modulates PTPRZ1 Activity and RNA m6A Modifications in Neuroinflammation-Associated Microglial Response., PMID:39921492
Vaccine-induced T cell receptor T cell therapy targeting a glioblastoma stemness antigen., PMID:39893177
The roles of pleiotrophin in brain injuries: a narrative review of the literature., PMID:39829367
High cellular plasticity state of medulloblastoma local recurrence and distant dissemination., PMID:39809264
Astrocyte-derived PTN alleviates deficits in hippocampal neurogenesis and cognition in models of multiple sclerosis., PMID:39729991
Integrin α6β4 Upregulates PTPRZ1 Through UCHL1-Mediated Hif-1α Nuclear Accumulation to Promote Triple-Negative Breast Cancer Cell Invasive Properties., PMID:39518121
PTPRZ1 dephosphorylates and stabilizes RNF26 to reduce the efficacy of TKIs and PD-1 blockade in ccRCC., PMID:39443724
Cell Fate Dynamics Reconstruction Identifies TPT1 and PTPRZ1 Feedback Loops as Master Regulators of Differentiation in Pediatric Glioblastoma-Immune Cell Networks., PMID:39420135
Pleiotrophin Activates cMet- and mTORC1-Dependent Protein Synthesis through PTPRZ1-The Role of ανβ3 Integrin., PMID:39409168
PTPRZ1-Targeting RNA CAR T Cells Exert Antigen-Specific and Bystander Antitumor Activity in Glioblastoma., PMID:39269445
IL-34 and its receptors as predictors of brain metastasis and prognosis in lung adenocarcinoma: Unveiling insights through bioinformatic and immunohistochemical investigations., PMID:39055827
Novel RPTPγ and RPTPζ splice variants from mixed neuron-astrocyte hippocampal cultures as well as from the hippocampi of newborn and adult mice., PMID:38952869
Data-independent acquisition combined with liquid chromatography mass spectrometry technique to detect prognostic protein markers in type I gastric neuroendocrine neoplasm., PMID:38887896
Targeting the interaction of pleiotrophin and VEGFA165 with protein tyrosine phosphatase receptor zeta 1 inhibits endothelial cell activation and angiogenesis., PMID:38821164
Prolonged complete response to adjuvant tepotinib in a patient with newly diagnosed disseminated glioblastoma harboring mesenchymal-epithelial transition fusion., PMID:38815166
The PTPRZ1-MET/STAT3/ISG20 axis in glioma stem-like cells modulates tumor-associated macrophage polarization., PMID:38685521
Challenges in the discovery of tumor-specific alternative splicing-derived cell-surface antigens in glioma., PMID:38493204
Gene-gene interaction network analysis indicates CNTN2 is a candidate gene for idiopathic generalized epilepsy., PMID:38460076
Single-cell RNA sequencing of anaplastic ependymoma and H3K27M-mutant diffuse midline glioma., PMID:38383423
Clear-cell papillary renal cell tumour: New insights into clinicopathological features and molecular landscape after renaming by 5th WHO classification., PMID:38324963
An in-silico analysis reveals further evidence of an aggressive subset of lung carcinoids sharing molecular features of high-grade neuroendocrine neoplasms., PMID:38237798
HSV1 microRNAs in glioblastoma development: an in silico study., PMID:38167429
Genetic Factors and Long-term Treatment-Related Neurocognitive Deficits, Anxiety, and Depression in Childhood Leukemia Survivors: An Exome-Wide Association Study., PMID:38051303
Network analysis of transcriptomic data uncovers molecular signatures and the interplay of mRNAs, lncRNAs, and miRNAs in human embryonic stem cells., PMID:38008592
Challenges in the discovery of tumor-specific alternative splicing-derived cell-surface antigens in glioma., PMID:37961484
Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell RNA-seq analysis., PMID:37955814
The Combination of Quantitative Proteomics and Systems Genetics Analysis Reveals that PTN Is Associated with Sleep-Loss-Induced Cognitive Impairment., PMID:37611228
Pleiotrophin ameliorates age-induced adult hippocampal neurogenesis decline and cognitive dysfunction., PMID:37610873
MYEF2: an immune infiltration-related prognostic factor in IDH-wild-type glioblastoma., PMID:37556355
Pleiotrophin and the Expression of Its Receptors during Development of the Human Cerebellar Cortex., PMID:37443767
Protein-protein interactions between tenascin-R and RPTPζ/phosphacan are critical to maintain the architecture of perineuronal nets., PMID:37356715
Genetic deletion or tyrosine phosphatase inhibition of PTPRZ1 activates c-Met to up-regulate angiogenesis and lung adenocarcinoma growth., PMID:37260355
Implication of the PTN/RPTPβ/ζ Signaling Pathway in Acute Ethanol Neuroinflammation in Both Sexes: A Comparative Study with LPS., PMID:37238989
Protein Tyrosine Phosphatase Receptor Zeta 1 as a Potential Target in Cancer Therapy and Diagnosis., PMID:37175798
A retrospective analysis of phosphatase catalytic subunit gene variants in patients with rare disorders identifies novel candidate neurodevelopmental disease genes., PMID:37056996
Brain-specific glycosylation of protein tyrosine phosphatase receptor type Z (PTPRZ) marks a demyelination-associated astrocyte subtype., PMID:37005741
Quantitative Evaluation of Stem-like Markers of Human Glioblastoma Using Single-Cell RNA Sequencing Datasets., PMID:36900348
Single cell cortical bone transcriptomics define novel osteolineage gene sets altered in chronic kidney disease., PMID:36777346
Inhibition of RPTPβ/ζ reduces chronic ethanol intake in adolescent mice and modulates ethanol effects on hippocampal neurogenesis and glial responses in a sex-dependent manner., PMID:36706907
Pleiotrophin deficiency protects against high-fat diet-induced neuroinflammation: Implications for brain mitochondrial dysfunction and aberrant protein aggregation., PMID:36566969
Detection and genomic analysis of BRAF fusions in Juvenile Pilocytic Astrocytoma through the combination and integration of multi-omic data., PMID:36503484
Expression of the pleiotrophin-midkine axis in a sheep tooth socket model of bone healing., PMID:36411509
Identification of MET fusions in solid tumors: A multicenter, large scale study in China., PMID:36408924
PTN-PTPRZ1 signaling axis blocking mediates tumor microenvironment remodeling for enhanced glioblastoma treatment., PMID:36402232
Targeted OUM1/PTPRZ1 silencing and synergetic CDT/enhanced chemical therapy toward uveal melanoma based on a dual-modal imaging-guided manganese metal-organic framework nanoparticles., PMID:36335349
Integrated Analysis of Cortex Single-Cell Transcriptome and Serum Proteome Reveals the Novel Biomarkers in Alzheimer's Disease., PMID:36009085
The Glycoprotein M6a Is Associated with Invasiveness and Radioresistance of Glioblastoma Stem Cells., PMID:35883571
For research use only. Not for human or drug use.
