Catalog No.
YHD56301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asn68-Ser280
Predicted molecular weight
26.36 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P23276
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Kell blood group glycoprotein, KEL, CD238
Note
For research use only.
Three missense mutations found in the KEL gene lead to K(mod) or K0 red blood cell phenotypes., PMID:25041236
Provision of KEL1-negative blood to obstetric patients: a 3-year single-institution retrospective review., PMID:25118004
Novel alleles at the Kell blood group locus that lead to Kell variant phenotype in the Dutch population., PMID:25156717
Acute extravascular hemolytic transfusion reaction due to anti-Kpa antibody missed by electronic crossmatch., PMID:25175412
The prevalence of anti-K in Canadian prenatal patients., PMID:25968929
Anti-KEL sera prevents alloimmunization to transfused KEL RBCs in a murine model., PMID:26185172
Kell and Kx blood group systems., PMID:26308465
NON-INVASIVE MONITORING OF FOETAL ANAEMIA IN KELL SENSITIZED PREGNANCY., PMID:26411147
Clinical Potential of Effective Noninvasive Exclusion of KEL1-Positive Fetuses in KEL1-Negative Pregnant Women., PMID:26492079
Riboflavin-ultraviolet light pathogen reduction treatment does not impact the immunogenicity of murine red blood cells., PMID:26643781
Clinically significant anti-KEL RBC alloantibodies are transferred by breast milk in a murine model., PMID:26950259
New KEL*01M and KEL*02M alleles: structural modeling to assess the impact of amino acid changes., PMID:26996808
Effect of Irradiation on Microparticles in Red Blood Cell Concentrates., PMID:27139610
Antigen modulation as a potential mechanism of anti-KEL immunoprophylaxis in mice., PMID:27688803
An innovative test for non-invasive Kell genotyping on circulating fetal DNA by means of the allelic discrimination of K1 and K2 antigens., PMID:27730708
Three new alleles encoding an apparent Kellnull phenotype., PMID:27861976
Antigen Density Dictates Immune Responsiveness following Red Blood Cell Transfusion., PMID:28250159
Genetically engineered red cells expressing single domain camelid antibodies confer long-term protection against botulinum neurotoxin., PMID:28871080
Silent KEL alleles identified from Japanese individuals with the Ko phenotype., PMID:29280152
Fc-Glycosylation in Human IgG1 and IgG3 Is Similar for Both Total and Anti-Red-Blood Cell Anti-K Antibodies., PMID:29445378
Transfused platelets enhance alloimmune responses to transfused KEL-expressing red blood cells in a murine model., PMID:30418129
Complement serves as a switch between CD4+ T cell-independent and -dependent RBC antibody responses., PMID:30429364
Mutations in Chromatin Modifier and Ephrin Signaling Genes in Vein of Galen Malformation., PMID:30578106
A novel c.1664G > T(p.Gly555Val) mutation in the KEL gene encoding the Kmod phenotype., PMID:31077392
First report of a KELnull phenotype in Peru and a lesson of invisible genetic disparity., PMID:31176642
Establishment of KEL*01 and KEL*02 Genotyping to Recruit Uncommon, Kell-positive, Reagent Red Cells Among Thai Blood Donors., PMID:31625357
Low incidence of post-transfusion Kell (KEL1) alloimmunisation in patients under 50 years old., PMID:31769076
Do red cell alloantibodies continue to challenge breast fed babies?, PMID:32083382
Association between HLA-DRB1*01 and HLA-DRB1*15 with alloimmunisation in transfusion-dependent patients with thalassaemia., PMID:32227529
Poly(I:C) causes failure of immunoprophylaxis to red blood cells expressing the KEL glycoprotein in mice., PMID:32266378
Diversity of variant alleles encoding Kidd, Duffy, and Kell antigens in individuals with sickle cell disease using whole genome sequencing data from the NHLBI TOPMed Program., PMID:33231305
The effectiveness of KEL and RHCE fetal genotype assessment in alloimmunized women by minisequencing., PMID:33562967
An open-source python library for detection of known and novel Kell, Duffy and Kidd variants from exome sequencing., PMID:33567470
HLA-DRB1 molecules and the presentation of anchor peptides from RhD, RhCE, and KEL proteins., PMID:33675036
[Expression of circ-KEL in acute myeloid leukemia and its regulatory mechanisms in leukemic cells]., PMID:33910309
Novel KEL*02N allele in Saudi Arabia encoding a Kell null (K0 ) phenotype., PMID:34137046
Complement Plays a Critical Role in Inflammation-Induced Immunoprophylaxis Failure in Mice., PMID:34249009
A novel KEL null allele with c.223+1g>t leads to the absence of the Kpb antigen in a First Nation donor., PMID:34310722
Five novel silenced KEL*02 alleles., PMID:34554576
Novel KEL*02M allele in Austria encoding a Kmod phenotype., PMID:34910313
Recognizing Impaired Decisional Capacity in Vaccine Refusal: Reply to Kels and Kels., PMID:35120287
Functional Evaluation of KEL as an Oncogenic Gene in the Progression of Acute Erythroleukemia., PMID:35140839
Noninvasive diagnostics of fetal KEL*01.01 allele from maternal plasma of immunized women using digital PCR protocols., PMID:35191535
Novel KEL allele associated with loss of Kpb identified in a white blood donor., PMID:35852066
A novel KEL c.1414-1G>T allele in a polish patient with anti-Ku antibody., PMID:35932201
Use of KEL-1 negative red blood cells for emergency release., PMID:37563839
Epigenetic dissection of human blood group genes reveals regulatory elements and detailed characteristics of KEL and four other loci., PMID:38644556
Genetic profile of RHCE, Kell, Duffy, Kidd, Diego and MNS hybrid glycophorins blood groups in ethnic northeastern Thais: Alleles, genotypes and risk of alloimmunisation., PMID:38804163
A structure-based in silico analysis of the Kell blood group system., PMID:39726599
For research use only. Not for human or drug use.
