Catalog No.
YHD50101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly37-Ala275
Predicted molecular weight
27.35 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P22087
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
FBL, Histone-glutamine methyltransferase, 34 kDa nucleolar scleroderma antigen, FIB1, rRNA 2'-O-methyltransferase fibrillarin, U6 snRNA 2'-O-methyltransferase fibrillarin, FLRN
Expansion Microscopy Provides Nanoscale Insight into Nucleolar Reorganization and Nuclear Foci Formation during Nucleolar Stress., PMID:40391829
Coilin-containing nuclear biomolecular condensates in zebra finch Taeniopygia guttata growing oocytes., PMID:40374142
Rpl13a snoRNAs U34 and U35a: New Targets for Sickle Cell Disease Complications., PMID:40371475
FBL promotes hepatocellular carcinoma tumorigenesis and progression by recruiting YY1 to enhance CAD gene expression., PMID:40289107
Ribosome biogenesis is a therapeutic vulnerability in paediatric neuroblastoma., PMID:40196487
The C. elegans glutamate transporters GLT-4 and GLT-5 regulate protein expression, behavior, and lifespan., PMID:40147734
Nucleolar ribosomal RNA synthesis continues in differentiating lens fiber cells until abrupt nuclear degradation required for ocular lens transparency., PMID:40126102
Cucumber mosaic virus 2b directs fibrillarin translocation to plasmodesmata to promote viral movement., PMID:40028682
SNORD80-guided 2'-O-methylation stabilizes the lncRNA GAS5 to regulate cellular stress responses., PMID:39946530
LncRNAs chaperoning dynamic protein condensates in cancer cells., PMID:39706163
Coptisine acts as a nucleolus fluorescent probe in vitro., PMID:39706054
Advances in the structure and function of the nucleolar protein fibrillarin., PMID:39605984
lncRNAs maintain the functional phase state of nucleolar prion-like protein to facilitate rRNA processing., PMID:39579766
Identification of FBLL1 as a neuron-specific RNA 2'-O-methyltransferase mediating neuronal differentiation., PMID:39570315
Fibrillarin homologs regulate translation in divergent cell lineages during planarian homeostasis and regeneration., PMID:39567829
Viral condensates formed by Pea enation mosaic virus 2 sequester ribosomal components and suppress translation., PMID:39549315
Decoding the molecular script of 2'-O-ribomethylation: Implications across CNS disorders., PMID:39524798
Distinct effects of CDK8 module subunits on cellular growth and proliferation in Drosophila., PMID:39531377
Giardia fibrillarin: a bioinformatics exploration of sequence and structure., PMID:39527366
Enhancing low-dose radiotherapy efficacy with PARP inhibitors via FBL-mediated oxidative stress response in colorectal cancer., PMID:39516657
Expanding the landscape of systemic sclerosis-related autoantibodies through RNA immunoprecipitation coupled with massive parallel sequencing., PMID:39500147
Continuous nucleolar ribosomal RNA synthesis in differentiating lens fiber cells until abrupt nuclear degradation required for ocular lens transparency., PMID:39484610
The Drosophila ribonucleoprotein Clueless is required for ribosome biogenesis in vivo., PMID:39481601
PARP-1 negatively regulates nucleolar protein pool and mitochondrial activity: a cell protective mechanism., PMID:39294821
Fibrillarin reprograms glucose metabolism by driving the enhancer-mediated transcription of PFKFB4 in liver cancer., PMID:39182558
Significance of Systemic Scleroderma-Specific Autoantibodies in Idiopathic Interstitial Pneumonia., PMID:39156993
Proteomic profiling of Arabidopsis nuclei reveals distinct protein accumulation kinetics upon heat stress., PMID:39143125
Reduced dynamicity and increased high-order protein assemblies in dense fibrillar component of the nucleolus under cellular senescence., PMID:39111063
Impaired phase separation and nucleolar functions in hiPSC models of SNORD118-related ribosomopathies., PMID:39108718
SART3 reads methylarginine-marked glycine- and arginine-rich motifs., PMID:38985674
RNA 2'-O-methylation promotes persistent R-loop formation and AID-mediated IgH class switch recombination., PMID:38977974
Dotting Out AML by Targeting Fibrillarin., PMID:38924716
Myosin VI in the nucleolus of neurosecretory PC12 cells: its involvement in the maintenance of nucleolar structure and ribosome organization., PMID:38774650
Distinct effects of CDK8 module subunits on cellular growth and proliferation in Drosophila., PMID:38746212
Phase separation-competent FBL promotes early pre-rRNA processing and translation in acute myeloid leukaemia., PMID:38745030
FBL Promotes LPS-Induced Neuroinflammation by Activating the NF-κB Signaling Pathway., PMID:38623466
Unprecedented complexity of six coexisting autoimmune diseases: A case report., PMID:38567480
An integrative platform for detection of RNA 2'-O-methylation reveals its broad distribution on mRNA., PMID:38452769
Comprehensive map of ribosomal 2'-O-methylation and C/D box snoRNAs in Drosophila melanogaster., PMID:38416577
[Severe small bowel involvement and chronic intestinal pseudo-obstruction in systemic sclerosis (scleroderma): Pathophysiological, diagnostic and therapeutic basis, including parenteral nutrition]., PMID:38388303
2'-O-ribose methylation levels of ribosomal RNA distinguish different types of growth arrest in human dermal fibroblasts., PMID:38345344
Nicotiana benthamiana Methanol-Inducible Gene (MIG) 21 Encodes a Nucleolus-Localized Protein That Stimulates Viral Intercellular Transport and Downregulates Nuclear Import., PMID:38256832
Platinum-based drugs induce phenotypic alterations in nucleoli and Cajal bodies in prostate cancer cells., PMID:38218884
NOC1 is a direct MYC target, and its protein interactome dissects its activity in controlling nucleolar function., PMID:38213308
The capsid protein of citrus leprosis virus C shows a nuclear distribution and interacts with the nucleolar fibrillarin protein., PMID:38070688
Fibrillarin promotes homologous recombination repair by facilitating the recruitment of recombinase RAD51 to DNA damage sites., PMID:38057273
Proximal Molecular Probe Transfer (PROMPT), a new approach for identifying sites of protein/nucleic acid interaction in cells by correlated light and electron microscopy., PMID:38052818
Nucleolar reorganization after cellular stress is orchestrated by SMN shuttling between nuclear compartments., PMID:37968267
Prevalence and Clinical Implications of Scleroderma-Specific Autoantibodies in Seronegative Patients with Sicca Complaints., PMID:37941855
Trypanosoma cruzi Fibrillarins: Two paralogous proteins with non-identical signals for nuclear transport., PMID:37832384
For research use only. Not for human or drug use.
