Catalog No.
RHE72105
Species reactivity
Human, Mouse, Rat
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
IHC: 1:50-1:100, WB: 1:500-1:1000
Target
Glycogen synthase kinase-3 beta, GSK3B, Serine/threonine-protein kinase GSK3B, GSK-3 beta
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P49841
Applications
IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.5% BSA, 0.05% Sodium Azide and 50% Glycerol.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3M09
Endogenous tau released from human ReNCell VM cultures by neuronal activity is phosphorylated at multiple sites., PMID:38854111
Proton pump inhibitors stabilize the expression of PD-L1 on cell membrane depending on the phosphorylation of GSK3β., PMID:38752436
Impact of glycogen synthase kinase-3ß inhibition on rats' temporomandibular joint collagen-induced rheumatoid arthritis with correlation to miRNA-155/miRNA-24 expression., PMID:37667918
Stabilization of E-cadherin adhesions by COX-2/GSK3β signaling is a targetable pathway in metastatic breast cancer., PMID:36757813
A comparative mRNA- and miRNA transcriptomics reveals novel molecular signatures associated with metastatic prostate cancers., PMID:36468011
Characterization of immune checkpoint inhibitor-induced cardiotoxicity reveals interleukin-17A as a driver of cardiac dysfunction after anti-PD-1 treatment., PMID:36356191
TIMELESS is a key gene mediating thrombogenesis in COVID-19 and antiphospholipid syndrome., PMID:36241659
LRRK2 is required for CD38-mediated NAADP-Ca2+ signaling and the downstream activation of TFEB (transcription factor EB) in immune cells., PMID:34313548
Platelet-rich plasma protects human melanocytes from oxidative stress and ameliorates melanogenesis induced by UVB irradiation., PMID:33974003
TSPAN1 promotes autophagy flux and mediates cooperation between WNT-CTNNB1 signaling and autophagy via the MIR454-FAM83A-TSPAN1 axis in pancreatic cancer., PMID:32972302
Assessment of anti-cancer effects of koenimbine on colon cancer cells., PMID:32116245
Antigen-Based Nano-Immunotherapy Controls Parasite Persistence, Inflammatory and Oxidative Stress, and Cardiac Fibrosis, the Hallmarks of Chronic Chagas Cardiomyopathy, in A Mouse Model of Trypanosoma cruzi Infection., PMID:32098116
CCN1 stimulated the osteoblasts via PTEN/AKT/GSK3β/cyclinD1 signal pathway in Myeloma Bone Disease., PMID:31769620
circGSK3β promotes metastasis in esophageal squamous cell carcinoma by augmenting β-catenin signaling., PMID:31722716
Secreted amphiregulin promotes vincristine resistance in oral squamous cell carcinoma., PMID:31485602
Cabozantinib induces PUMA-dependent apoptosis in colon cancer cells via AKT/GSK-3β/NF-κB signaling pathway., PMID:31182761
Isolation of induced pluripotent stem cell-derived endothelial progenitor cells from sac-like structures., PMID:31178142
MET Inhibitors Promote Liver Tumor Evasion of the Immune Response by Stabilizing PDL1., PMID:30711629
SA-49, a novel aloperine derivative, induces MITF-dependent lysosomal degradation of PD-L1., PMID:30711516
CEPO-Fc (An EPO Derivative) Protects Hippocampus Against Aβ-induced Memory Deterioration: A Behavioral and Molecular Study in a Rat Model of Aβ Toxicity., PMID:30102955
Methacholine induces extracellular matrix production by human airway smooth muscle cells through β-catenin signaling., PMID:29715518
Evidence of Signaling and Adhesion Roles for β-Catenin in the Sponge Ephydatia muelleri., PMID:29522209
A comparative global phosphoproteomics analysis of obinutuzumab (GA101) versus rituximab (RTX) against RTX sensitive and resistant Burkitt lymphoma (BL) demonstrates differential phosphorylation of signaling pathway proteins after treatment., PMID:29371955
Macrophage migration inhibitory factor promotes tumor aggressiveness of esophageal squamous cell carcinoma via activation of Akt and inactivation of GSK3β., PMID:29079416
Production of proinflammatory mediators in activated microglia is synergistically regulated by Notch-1, glycogen synthase kinase (GSK-3β) and NF-κB/p65 signalling., PMID:29049420
Altered expression of IGF-I system in neurons of the inflamed spinal cord during acute experimental autoimmune encephalomyelitis., PMID:28617951
Inhibition of glycogen synthase kinase 3 beta (GSK3β) suppresses the progression of esophageal squamous cell carcinoma by modifying STAT3 activity., PMID:28574599
MiR-410 induces stemness by inhibiting Gsk3β but upregulating β-catenin in non-small cells lung cancer., PMID:28076327
Twist1-induced epithelial-mesenchymal transition according to microsatellite instability status in colon cancer cells., PMID:27494849
The Tyr216 phosphorylated form of GSK3β contributes to tau phosphorylation at PHF-1 epitope in response to Aβ in the nucleus of SH-SY5Y cells., PMID:27343974
Multi-walled carbon nanotubes directly induce epithelial-mesenchymal transition in human bronchial epithelial cells via the TGF-β-mediated Akt/GSK-3β/SNAIL-1 signalling pathway., PMID:27251132
Regulatory T cells ameliorate intracerebral hemorrhage-induced inflammatory injury by modulating microglia/macrophage polarization through the IL-10/GSK3β/PTEN axis., PMID:27174997
C-Type Lectin-Like Receptor 2 Suppresses AKT Signaling and Invasive Activities of Gastric Cancer Cells by Blocking Expression of Phosphoinositide 3-Kinase Subunits., PMID:26855187
Inactivation of nuclear GSK3β by Ser(389) phosphorylation promotes lymphocyte fitness during DNA double-strand break response., PMID:26822034
DGAEE, a newly synthesized derivative of glycyrrhetinic acid, potently attenuates mouse septic shock via its main metabolite DGA in an IL-10-dependent manner., PMID:26456500
GSK-3β controls autophagy by modulating LKB1-AMPK pathway in prostate cancer cells., PMID:26440826
Trace amine-associated receptor 1 activation silences GSK3β signaling of TAAR1 and D2R heteromers., PMID:26372541
XB130 promotes bronchioalveolar stem cell and Club cell proliferation in airway epithelial repair and regeneration., PMID:26360608
Inhibitory Injury Signaling Represses Axon Regeneration After Dorsal Root Injury., PMID:26298667
IFN-γ promotes τ phosphorylation without affecting mature tangles., PMID:26156074
Phosphorylation and SCF-mediated degradation regulate CREB-H transcription of metabolic targets., PMID:26108621
Mori Fructus improves cognitive and neuronal dysfunction induced by beta-amyloid toxicity through the GSK-3β pathway in vitro and in vivo., PMID:26068423
Clinicopathological significance of wnt/β-catenin signaling pathway in esophageal squamous cell carcinoma., PMID:26045816
Transmembrane-Bound IL-15-Promoted Epithelial-Mesenchymal Transition in Renal Cancer Cells Requires the Src-Dependent Akt/GSK-3β/β-Catenin Pathway., PMID:26025664
[Expression Changes of β-catenin and P-GSK-3β in Patients with Mantle Cell Lymphoma]., PMID:25948194
Excitotoxicity induced by kainic acid provokes glycogen synthase kinase-3 truncation in the hippocampus., PMID:25779040
Caloric restriction mimetic 2-deoxyglucose maintains cytoarchitecture and reduces tau phosphorylation in primary culture of mouse hippocampal pyramidal neurons., PMID:25678460
Cathelicidin, an antimicrobial peptide produced by macrophages, promotes colon cancer by activating the Wnt/β-catenin pathway., PMID:25596747
Overexpression of interleukin-18 protein reduces viability and induces apoptosis of tongue squamous cell carcinoma cells by activation of glycogen synthase kinase-3β signaling., PMID:25591548
Inhibition of glycogen synthase kinase-3β prevents sympathetic hyperinnervation in infarcted rats., PMID:25576342
For research use only. Not for human or drug use.
