Anti-MSH2 Antibody (R3L03)

Catalog No.

RHE40503

Species reactivity

Human, Mouse

Host species

Mouse

Isotype

IgG1

Clonality

Monoclonal

Tested applications

IF: 1:50-1:500, IHC: 1:100-1:500, WB: 1:500-1:2000

Target

hMSH2, MutS protein homolog 2, MSH2, DNA mismatch repair protein Msh2

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P43246

Applications

IF, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% Sodium Azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

R3L03

[Microsatellite instability as a possible diagnostic marker of the gastric mucosa dysplasia]., PMID:40531552

Immunohistochemical and molecular evolutionary features of jejunoileal adenocarcinoma unveiled through comparative analysis with colorectal adenocarcinoma., PMID:40403397

Detecting microsatellite instability in cancer via multiplexed orthogonal gap-enhanced Raman tags., PMID:40386153

Comparison of survival outcomes for patients with Lynch vs non-Lynch syndrome and microsatellite unstable colorectal cancer treated with immunotherapy., PMID:39932790

Case report: Chemotherapy plus sintilimab for the treatment of gastroesophageal junction hepatoid adenocarcinoma with liver metastasis: a case study with literature review., PMID:39931054

[Application of PMS2 and MSH6 double-antibody detection in screening of mismatch repair deficient tumors]., PMID:39863527

Intraoperative rapid immunohistochemistry of microsatellite instability using non-contact alternating current electric field mixing., PMID:39443409

Single Center Characterization of a Cohort of Salivary Gland Carcinomas., PMID:39337873

Durable response to pembrolizumab in hepatic metastasis from colonic carcinoma with Lynch syndrome: a case report., PMID:39247185

Universal testing in endometrial cancer in Sweden., PMID:39175077

Intriguing Insights From 100 Consecutive Colorectal Cancer Cases in Mid-Kerala: Sparse BRAF Gene Mutations and Mismatch Repair Deficiency (MMR-D)., PMID:39119381

Analysis of translesion polymerases in colorectal cancer cells following cetuximab treatment: A network perspective., PMID:39102671

Mismatch repair deficiency: how reliable is the two-antibody approach? A national real-life study., PMID:38859771

Diagnostic and prognostic assessments of adrenocortical carcinomas by pathological features, immunohistochemical markers and reticular histochemistry staining., PMID:38802933

Assessing Mismatch Repair Expression by Immunohistochemistry in Colorectal Adenocarcinoma -Insight from a Tertiary Care Centre., PMID:38774931

The Relationship of Microsatellite Instability with BRAF and p53 Mutations and Histopathological Parameters in Colorectal Adenocarcinoma., PMID:38684491

[Expression of immune checkpoints PD-L1, CTLA4, LAG3 in the microenvironment of colon adenocarcinoma depending on MMR status]., PMID:38591901

HER2-low and Overexpression in Mucinous Ovarian Cancer: Analysis of ASCO/CAP and ToGA Immunohistochemical Scoring., PMID:38436360

Clinicopathological features and evaluation of microsatellite stability of colorectal carcinoma with cribriform comedo pattern., PMID:38394410

Next-generation sequencing and immunohistochemistry approaches for microsatellite instability detection in endometrial cancer., PMID:38279425

The relationship between DNA mismatch repair gene and other prognostic parameters in pancreatic adenocarcinoma., PMID:38173349

Clinicopathologic features of conjunctival MALT lymphomas refractory to radiation therapy., PMID:38101452

Expression of Programmed Cell Death Ligand-1 and Mismatch Repair Status in Endometrial Carcinomas., PMID:38029026

ATR inhibition induces synthetic lethality in mismatch repair-deficient cells and augments immunotherapy., PMID:37932012

Deficient Mismatch Repair Proteins in Gastric Mixed Neuroendocrine Non-Neuroendocrine Neoplasm: A Rare Case Report., PMID:37900850

Phase II Trial of Nivolumab in Metastatic Rare Cancer with dMMR or MSI-H and Relation with Immune Phenotypic Analysis (the ROCK Trial)., PMID:37819940

Deep Learning Can Predict Bevacizumab Therapeutic Effect and Microsatellite Instability Directly from Histology in Epithelial Ovarian Cancer., PMID:37741509

Rechallenge With Switching Immune Checkpoint Inhibitors Following Autoimmune Myocarditis in a Patient With Lynch Syndrome., PMID:37673116

Mismatch Repair Deficient (dMMR) Colorectal Carcinoma in a Pakistani Cohort: Association With Clinical and Pathological Parameters., PMID:37664303

Mismatch Repair Protein Expression in Endometrial Cancer: Assessing Concordance and Unveiling Pitfalls in Two Different Immunohistochemistry Assays., PMID:37623510

Early-Onset/Young-Onset Colorectal Carcinoma: A Comparative Analysis of Morphological Features and Biomarker Profile., PMID:37621838

A pathological complete response after immunotherapy with pembrolizumab for distal duodenal adenocarcinoma caused by Lynch syndrome: a case report., PMID:37577343

A Japanese case of ovarian mucinous adenocarcinoma with germline double variants of MSH2 and BRCA2., PMID:37420004

Short-term immune-checkpoint inhibition partially rescues perturbed bone marrow hematopoiesis in mismatch-repair deficient tumors., PMID:37396958

Mixed acinar-neuroendocrine carcinoma of the pancreas with positive for microsatellite instability: a case report and review of the literature., PMID:37386324

MTHFR act as a potential cancer biomarker in immune checkpoints blockades, heterogeneity, tumor microenvironment and immune infiltration., PMID:37354330

The expression of programmed death-ligand 1 and programmed death-ligand 2 in endometrial carcinosarcoma: Correlation with mismatch repair protein expression status, tumor-infiltrating lymphocyte infiltration, and clinical outcomes., PMID:37060883

Complete Response to Immune Checkpoint Inhibition in a Platinum Resistant Primary Ovarian Cancer Patient With Lynch Syndrome: A Case Report and Review of the Literature., PMID:36974818

Lymph-node metastasis from gastric adenocarcinoma in a patient bearing a germ line missense variant MSH2 c.1808A > T (Asp603Val) responds to the immune checkpoint inhibitor pembrolizumab., PMID:36484308

[Microsatellite instability in gastric cancer is a predictor of a favorable prognosis]., PMID:36469712

Correlation of PD-L1 immunohistochemical expression with microsatellite instability and p53 status in endometrial carcinoma., PMID:36440057

Mismatch repair proteins expression and tumor-infiltrating T-cells in colorectal cancer., PMID:36276483

Validity of a two-antibody testing algorithm for mismatch repair deficiency testing in cancer; a systematic literature review and meta-analysis., PMID:36104536

An Evaluation of the Immunohistochemical Expression of Mismatch Repair Proteins (MSH2, MSH6, MLH1, and PMS2) in Prostate Adenocarcinoma., PMID:36051725

Mismatch Repair Deficiency in Adult Granulosa Cell Tumors: an Immunohistochemistry-based Preliminary Study., PMID:35960021

Overcoming resistance to αPD-1 of MMR-deficient tumors with high tumor-induced neutrophils levels by combination of αCTLA-4 and αPD-1 blockers., PMID:35896284

CDK4/6 blockade provides an alternative approach for treatment of mismatch-repair deficient tumors., PMID:35845723

A Human MSH6 Germline Variant Associated With Systemic Lupus Erythematosus Induces Lupus-like Disease in Mice., PMID:35708944

Dandelion Seed Extract Affects Tumor Progression and Enhances the Sensitivity of Cisplatin in Esophageal Squamous Cell Carcinoma., PMID:35668940

Immunotherapy in Penile Squamous Cell Carcinoma: Present or Future? Multi-Target Analysis of Programmed Cell Death Ligand 1 Expression and Microsatellite Instability., PMID:35592855

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Anti-MSH2 Antibody (R3L03).pdf