Catalog No.
YHD45601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ile1034-Leu1286
Predicted molecular weight
30.04 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P21439
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Multidrug resistance protein 3, MDR3, ATP-binding cassette sub-family B member 4, PGY3, Phosphatidylcholine translocator ABCB4, ABCB4, P-glycoprotein 3
Ion Channel-Extracellular Matrix Interplay in Colorectal Cancer: A Network-Based Approach to Tumor Microenvironment Remodeling., PMID:40507957
Species difference in the excretion routes of Ciprofol (HSK3486) in rats and humans: Contribution of hepatic transporters and renal UDP-glucuronosyltransferase enzymes., PMID:40456195
Immunohistochemistry in Progressive Familial Intrahepatic Cholestasis (PFIC): Bridging Gap Between Morphology and Genetics., PMID:40384941
Network Pharmacology-Based Elucidation of the Hypoglycemic Mechanism of Grifola frondosa GF5000 Polysaccharides via GCK modulation in Diabetic Rats., PMID:40289960
Clinical, genetic and functional perspectives on ATP-binding cassette subfamily B member 4 variants in five cholestasis adults., PMID:40248383
Pharmacogenomics in pediatric oncology patients with solid tumors related to chemotherapy-induced toxicity: A systematic review., PMID:40222694
Clinical and molecular genetic characteristics of pediatric PFIC3 patients: three novel variants and prognosis for parental liver transplantation., PMID:40200381
Model of baseline clinicopathological features predicts non-resolution of drug-induced liver injury at 6 months., PMID:40180706
Novel ABCB4 mutation in a female patient with progressive familial intrahepatic cholestasis type 3: a case report and literature review., PMID:40110281
Identification of Systemic Drug Targets for Anti-cavernous Fibrosis in the Treatment of Erectile Dysfunction, Guided by Genome-Wide Mendelian Randomization., PMID:40077914
Unveiling the Genetic Culprit: A Diagnostic Dilemma of Recurrent Cholestasis With Intrahepatic Stones., PMID:40018694
Edaravone is a Therapeutic Candidate for Doxorubicin-Induced Cardiomyopathy by Activating the Nrf2 Pathway., PMID:39865410
Association between ABCB4 variants and intrahepatic cholestasis of pregnancy., PMID:39865141
Enhancement of Doxorubicin Efficacy by Bacopaside II in Triple-Negative Breast Cancer Cells., PMID:39858449
Liver GPBAR1 Associates With Immune Dysfunction in Primary Sclerosing Cholangitis and Its Activation Attenuates Cholestasis in Abcb4-/- Mice., PMID:39804015
A family with gallstone disease: defining inherited risk in the era of clinical genetic testing., PMID:39786488
Current approach to diagnosis and management of low-phospholipid associated cholelithiasis syndrome., PMID:39782681
Dietary high lipid and high plant-protein affected growth performance, liver health, bile acid metabolism and gut microbiota in groupers., PMID:39640555
A Case of Progressive Familial Intrahepatic Cholestasis Type-3., PMID:39618628
The association of ABC proteins with multidrug resistance in cancer., PMID:39571941
[Clinical characteristics of ABCB4 gene variant-associated cholestatic liver disease in adults]., PMID:39528329
Identification of novel ABCB4 variants and genotype-phenotype correlation in progressive familial intrahepatic cholestasis type 3., PMID:39521930
Expanding the spectrum of progressive familial intrahepatic cholestasis: A report of 3 cases., PMID:39333837
Identification of NanoLuciferase Substrates Transported by Human ABCB1 and ABCG2 and Their Zebrafish Homologs at the Blood-Brain Barrier., PMID:39322411
Differing temperature dependencies of functional homologs zebrafish Abcb4 and human ABCB1., PMID:39166110
The spectrum of novel ABCB11 gene variations in children with progressive familial intrahepatic cholestasis type 2 in Pakistani cohorts., PMID:39143102
ABC transporters involved in respiratory and cholestatic diseases: From rare to very rare monogenic diseases., PMID:39111603
Abcb4-defect cholangitis mouse model with hydrophobic bile acid composition by in vivo liver-specific gene deletion., PMID:39111549
Role of P-glycoprotein in Regulating the Efficacy, Toxicity and Pharmacokinetics of Yunaconitine., PMID:39108114
Transposon-based oncogene integration in Abcb4(Mdr2)-/- mice recapitulates high susceptibility to cholangiocarcinoma in primary sclerosing cholangitis., PMID:39089631
Picroside II promotes HSC apoptosis and inhibits the cholestatic liver fibrosis in Mdr2-/- mice by polarizing M1 macrophages and balancing immune responses., PMID:39059828
Identification of new correctors for traffic-defective ABCB4 variants by a high-content screening approach., PMID:39048674
Acute hepatotoxicity of intravenous amiodarone in a Becker muscular dystrophy patient with decompensated heart failing and ABCB4 gene mutation: as assessed for causality using the updated RUCAM., PMID:39044225
Peripherally Restricted CB1 Receptor Inverse Agonist JD5037 Treatment Exacerbates Liver Injury in MDR2-Deficient Mice., PMID:38994954
[Clinical phenotype and genotype analysis of progressive familial intrahepatic cholestasis type 3 caused by novel ABCB4 gene mutation]., PMID:38955683
Low phospholipid-associated cholelithiasis syndrome, a not uncommon cause of biliary problems and hospital admissions., PMID:38874003
Magnetic resonance imaging features of progressive familial intrahepatic cholestasis type 3., PMID:38829428
The putative proton-coupled organic cation antiporter is involved in uptake of triptans into human brain capillary endothelial cells., PMID:38711118
Glioblastoma stem cells deliver ABCB4 transcribed by ATF3 via exosomes conferring glioblastoma resistance to temozolomide., PMID:38710703
Blockade of neutrophil extracellular trap components ameliorates cholestatic liver disease in Mdr2 (Abcb4) knockout mice., PMID:38653165
[Analysis of clinical characteristic of children with progressive familial intrahepatic cholestasis type 3]., PMID:38623015
Clinical and genetic study of ABCB4 gene-related cholestatic liver disease in China: children and adults., PMID:38610052
Role of ABCB1 and ABCB4 in renal and biliary excretion of perfluorooctanoic acid in mice., PMID:38522903
The roles of ABCB1/P-glycoprotein drug transporters in regulating gut microbes and inflammation: insights from animal models, old and new., PMID:38497255
Abcg2a is the functional homolog of human ABCG2 expressed at the zebrafish blood-brain barrier., PMID:38491505
Molecular Insights of Cholestasis in MDR2 Knockout Murine Liver Organoids., PMID:38488493
Genetics of Gallstone Disease and Their Clinical Significance: A Narrative Review., PMID:38426197
Clinical outcomes of ABCB4 heterozygosity in infants and children with cholestatic liver disease., PMID:38374565
Searching for low phospholipid associated cholelithiasis among patients with post-cholecystectomy biliary pain., PMID:38361311
The noncanonical nucleotide binding site 1 of the bile salt export pump is optimized for proper function of the transporter., PMID:38328902
For research use only. Not for human or drug use.
