Catalog No.
YHD44101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg52-Arg164
Predicted molecular weight
39.87 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P20963
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CD3Z, CD247, TCRZ, T-cell receptor T3 zeta chain, T3Z, T-cell surface glycoprotein CD3 zeta chain
Note
For research use only.
Disrupting the phase separation of KAT8-IRF1 diminishes PD-L1 expression and promotes antitumor immunity., PMID:36894639
Screening of potential immune-related genes expressed during sepsis using gene sequencing technology., PMID:36918563
Engineering second-generation TCR-T cells by site-specific integration of TRAF-binding motifs into the CD247 locus., PMID:37019470
Identification of multiple novel susceptibility genes associated with autoimmune thyroid disease., PMID:37197658
Genetic analysis of cuproptosis subtypes and immunological features in severe influenza., PMID:37207785
Identification of ribosomal protein family as immune-cell-related biomarkers of NAFLD by bioinformatics and experimental analyses., PMID:37274336
Whole-genome bisulfite sequencing identified the key role of the Src family tyrosine kinases and related genes in systemic lupus erythematosus., PMID:37300789
Functional NADPH oxidase 2 in T cells amplifies salt-sensitive hypertension and associated renal damage., PMID:37318993
CD3D and CD247 are the molecular targets of septic shock., PMID:37478215
Expression and clinical significance of PD-1 in UCEC and its Impact on tumor., PMID:37571885
Identification of Potential Biomarkers of Septic Shock Based on Pathway and Transcriptome Analyses of Immune-Related Genes., PMID:37575977
Analysis of Enrichment Pathway, Hub Gene, and Protein-Protein Interaction Network in Rheumatoid Arthritis and Construction of Molecular Subtypes in Peripheral Blood., PMID:37773661
A hub gene signature as a therapeutic target and biomarker for sepsis and geriatric sepsis-induced ARDS concomitant with COVID-19 infection., PMID:37822934
Biomarkers in the Pathogenesis, Diagnosis, and Treatment of Systemic Sclerosis., PMID:37868834
T-cells regulate albuminuria but not hypertension, renal histology, or the medullary transcriptome in the Dahl SSCD247+/+ rat., PMID:37916287
The integrative multi-omics approach identifies the novel competing endogenous RNA (ceRNA) network in colorectal cancer., PMID:37945594
Coexistent ARID1A-PIK3CA mutations are associated with immune-related pathways in luminal breast cancer., PMID:38017109
Identification of potential therapeutic drugs targeting core genes for systemic lupus erythematosus (SLE) and coexisting COVID-19: Insights from bioinformatic analyses., PMID:38018597
Alternatively Spliced Variants of Murine CD247 Influence T Cell Development and Activation, Revealing the Importance of the CD3ζ C-Terminal Region., PMID:38117282
Revealing novel genomic insights and therapeutic targets for juvenile idiopathic arthritis through omics., PMID:38317060
Prognostic stratification of sepsis through DNA damage response based RiskScore system: insights from single-cell RNA-sequencing and transcriptomic profiling., PMID:38404591
Integration of ζ-deficient CARs into the CD3ζ gene conveys potent cytotoxicity in T and NK cells., PMID:38493479
Six-gene prognostic signature for non-alcoholic fatty liver disease susceptibility using machine learning., PMID:38728481
Exploring T-cell exhaustion features in Acute myocardial infarction for a Novel Diagnostic model and new therapeutic targets by bio-informatics and machine learning., PMID:38783198
Identification of biomarkers for abdominal aortic aneurysm in Behçet's disease via mendelian randomization and integrated bioinformatics analyses., PMID:38785203
Identification of a Fully Human Antibody VH Domain Targeting Anaplastic Lymphoma Kinase (ALK) with Applications in ALK-Positive Solid Tumor Immunotherapy., PMID:38804307
Unraveling the non-fitness status of NK cells: Examining the NKp30 receptor and its isoforms distribution in HIV/HCV coinfected patients., PMID:38850777
Three-gene signature revealing the dynamics of lymphocyte infiltration in subchondral bone during osteoarthritis progression., PMID:38897125
Nonsense CD247 mutations show dominant-negative features in T-cell receptor expression and function., PMID:38992472
Function of unconventional T cells in oral lichen planus revealed by single-cell RNA sequencing., PMID:39073597
FASLG as a Key Member of Necroptosis Participats in Acute Myocardial Infarction by Regulating Immune Infiltration., PMID:39205966
Identification of key immune-related genes and potential therapeutic targets in immune checkpoint inhibitor-associated myocarditis., PMID:39251231
Genomic insights into mRNA COVID-19 vaccines efficacy: Linking genetic polymorphisms to waning immunity., PMID:39254005
Recurrent ocular toxoplasmosis is associated with interferon-gamma deficiency possibly due to genetic origin., PMID:39277179
Intact NOX2 in T Cells Mediates Pregnancy-Induced Renal Damage in Dahl SS Rats., PMID:39301728
Decreased Expression of CD247 and CD4 Immune Marker Predicts Poor Prognosis in Triple Negative Breast Cancer., PMID:39342598
Effects of immunorelated gene polymorphisms on trastuzumab targeting breast cancer cell in vitro., PMID:39392082
Risk of celiac disease autoimmunity is modified by interactions between CD247 and environmental exposures., PMID:39462122
Functional investigation and two-sample Mendelian randomization study of primary biliary cholangitis hub genes., PMID:39464319
Causal relationship between hypothyroidism and ulcerative colitis: a bidirectional Mendelian randomization study., PMID:39478467
mRNA-seq-based analysis predicts: AEG-1 is a therapeutic target and immunotherapy biomarker for pan-cancer, including OSCC., PMID:39483471
Telomerase RNA component knockout exacerbates Staphylococcus aureus pneumonia by extensive inflammation and dysfunction of T cells., PMID:39607755
Sexual dimorphism in lung transcriptomic adaptations in fetal alcohol spectrum disorders., PMID:39780208
Mendelian Randomization Reveals Potential Causal Relationships Between DNA Damage Repair-Related Genes and Inflammatory Bowel Disease., PMID:39857814
Methylation profile of CD247 and FOXP3 genes and frequency of certain HLA-DQ haplotypes in Celiac disease., PMID:40010434
Transcriptomic sequencing of multiple salivary glands combined with bioinformatics analysis reveals key genes in primary Sjögren's syndrome., PMID:40227387
Identification and Validation of T Cell-Related Hub Biomarkers for Early Diagnosis of Diabetic Kidney Disease Using Single-Cell and Bulk Dataset Analysis., PMID:40228227
Ubiquitin-proteasome Pathway-linked Gene Signatures as Prognostic Indicators in Prostate Cancer., PMID:40295064
Identification of Natural Killer Cell-Related Genes as Potential Diagnostic Biomarkers for Pediatric Sepsis., PMID:40411297
Sequence Variation in X-ray Cross Complimenting (XRCC4, XRCC5, XRCC6 and XRCC7) Genes and the Risk of Gastrointestinal Cancer in South-Western Maharashtra: A Hospital Based Case-Control Study., PMID:40439368
For research use only. Not for human or drug use.
