Catalog No.
YHD42101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ile602-Ala821
Predicted molecular weight
27.67 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P20807
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CANPL3, New calpain 1, nCL-1, Calpain p94, Calpain L3, CANP3, CAPN3, Calcium-activated neutral proteinase 3, Muscle-specific calcium-activated neutral protease 3, Calpain-3, NCL1, CANP 3
Calpainopathy (limb-girdle muscular dystrophy type R1): clinical features, diagnostic approaches, and biotechnological treatment methods., PMID:40452441
A survey on mutation spectrum in Iranian patients with limb-girdle muscular dystrophies., PMID:40361203
In situ detection of activation of CAPN3, a responsible gene product for LGMDR1, in mouse skeletal myotubes., PMID:40280419
Variants in CAPN3 Causing Autosomal Dominant Limb-Girdle Muscular Dystrophy Combined With Calpain-3 Deficiency., PMID:40226307
RNA Mis-Splicing Effects of Noncanonical Splicing Variants in Limb-Girdle Muscular Dystrophy Type R1/2A., PMID:40190443
The Role of Integrin β1D Mislocalization in the Pathophysiology of Calpain 3-Related Limb-Girdle Muscular Dystrophy., PMID:40136695
A rare homozygous CAPN3 variant with distinct clinical features in unrelated families of Iraqi Jewish descent., PMID:39973406
The N-Terminal Fragment of Urine Titin Is Not a Product of Degradation by Calpain 3., PMID:39777416
Human calpain-3 and its structural plasticity: Dissociation of a homohexamer into dimers on binding titin., PMID:39725035
Genetics of Exertional Heat Illness: Revealing New Associations and Expanding Heterogeneity., PMID:39457051
Capn3b-deficient zebrafish model reveals a key role of autoimmune response in LGMDR1., PMID:39349278
Expert panel curation of 31 genes in relation to limb girdle muscular dystrophy., PMID:39215466
Diagnosis of Two Unrelated Syndromes of Prader-Willi and Calpainopathy: Insight from Trio Whole Genome Analysis and Isodisomy Mapping., PMID:39062725
Loss of Calpain 3 dysregulates store-operated calcium entry and its exercise response in mice., PMID:39031532
Investigation of single nucleotide polymorphisms in differentially expressed genes and proteins reveals the genetic basis of skeletal muscle growth differences between Tibetan and Large White pigs., PMID:38938033
Two Novel Variants of the CAPN3 Gene in Chinese Patients with Limb-Girdle Muscular Dystrophy Recessive 1., PMID:38830343
A retrospective study on the clinical and molecular outcomes of calpainopathy in a Turkish patient cohort., PMID:38812636
Next generation sequencing panel as an effective approach to genetic testing in patients with a highly variable phenotype of neuromuscular disorders., PMID:38758368
Clinical application value of pre-pregnancy carrier screening in Chinese Han childbearing population., PMID:38562051
Identification of novel pathogenic variants of Calpain-3 gene in limb girdle muscular dystrophy R1., PMID:38561828
A Patient with Calpainopathy Carrying Compound Heterozygous Mutations of a De Novo Pathogenic Variant of c.1333G>A and a Novel Variant of c.1331C>T in CAPN3., PMID:38494715
Defining clinical endpoints in limb girdle muscular dystrophy: a GRASP-LGMD study., PMID:38491364
Novel Biomarkers for Limb Girdle Muscular Dystrophy (LGMD)., PMID:38391941
Identification and functional characterization of a novel heterozygous splice‑site mutation in the calpain 3 gene causes rare autosomal dominant limb‑girdle muscular dystrophy., PMID:38356676
The CAPN3 p.Lys 254del variant is not always associated with dominant CAPN3-related muscular dystrophy., PMID:38299438
Management of a 25-Year-Old Female Patient With Limb-Girdle Muscular Dystrophy With Physiotherapy: A Case Report., PMID:38298311
Loss of calpain 3 dysregulates store-operated calcium entry and its exercise response in mice., PMID:38293127
Engineered mischarged transfer RNAs for correcting pathogenic missense mutations., PMID:38104240
Magnetic resonance imaging-based criteria to differentiate dysferlinopathy from other genetic muscle diseases., PMID:38007344
Novel mutations in the SGCA gene in unrelated Vietnamese patients with limb-girdle muscular dystrophies disease., PMID:37900180
Single-centre experience with autosomal recessive limb-girdle muscular dystrophy: case series and literature review., PMID:37852290
Altered expression of proteins involved in metabolism in LGMDR1 muscle is lost in cell culture conditions., PMID:37817200
Combined sequence and copy number analysis improves diagnosis of limb girdle and other myopathies., PMID:37688281
Family and literature analysis demonstrates phenotypic effect of two variants in the calpain-3 gene., PMID:37589857
Hepatic depletion of nucleolar protein mDEF causes excessive mitochondrial copper accumulation associated with p53 and NRF1 activation., PMID:37456842
Calpain-3 Is Not a Sodium Dependent Protease and Simply Requires Calcium for Activation., PMID:37298357
Muscle Specific Promotors for Gene Therapy - A Comparative Study in Proliferating and Differentiated Cells., PMID:37270809
Missense mutation of c.635 T > C in CAPN3 impairs muscle injury repair in a Limb-Girdel Muscular Dystropy Model., PMID:36999564
Large Region of Homozygous (ROH) Identified in Indian Patients with Autosomal Recessive Limb-Girdle Muscular Dystrophy with p.Thr182Pro Variant in SGCB Gene., PMID:40225150
Cas9-induced single cut enables highly efficient and template-free repair of a muscular dystrophy causing founder mutation., PMID:36865086
High diagnostic yield of targeted next-generation sequencing panel as a first-tier molecular test for the patients with myopathy or muscular dystrophy., PMID:36575883
Family-based exome sequencing identifies candidate genes related to keratoconus in Chinese families., PMID:36118869
Co-expression of candidate genes regulating growth performance and carcass traits of Barki lambs in Egypt., PMID:35953554
An 86 amino acids motif in CAPN3 is essential for formation of the nucleolus-localized Def-CAPN3 complex., PMID:35878425
CAPN3 c.1746-20C>G variant is hypomorphic for LGMD R1 calpain 3-related., PMID:35731190
Generation of Calpain-3 knock-out porcine embryos by CRISPR-Cas9 electroporation and intracytoplasmic microinjection of oocytes before insemination., PMID:35500431
Disrupted myelination network in the cingulate cortex of Parkinson's disease., PMID:35394697
Current and Future Therapeutic Strategies for Limb Girdle Muscular Dystrophy Type R1: Clinical and Experimental Approaches., PMID:35366260
Targeting the Ubiquitin-Proteasome System in Limb-Girdle Muscular Dystrophy With CAPN3 Mutations., PMID:35309930
LGMD D2 TNPO3-Related: From Clinical Spectrum to Pathogenetic Mechanism., PMID:35309568
For research use only. Not for human or drug use.
