Catalog No.
RHD73617
Species reactivity
Human, Mouse, Rat
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
WB: 1:500-1:1000
Target
Microtubule-associated protein 2 kinase, p44-MAPK, Extracellular signal-regulated kinase 1, ERK1, MAPK3, MAP kinase isoform p44, Mitogen-activated protein kinase 3, ERK-1, PRKM3, Insulin-stimulated MAP2 kinase, p44-ERK1, MAPK 3, MAP kinase 3, ERT2, MAP kinase isoform p42, PRKM2, Extracellular signal-regulated kinase 2, MAPK 2, Mitogen-activated protein kinase 1, PRKM1, p42-MAPK, Mitogen-activated protein kinase 2, MAP kinase 1, MAP kinase 2, ERK2, ERT1, ERK-2, MAPK 1, MAPK1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P27361, P28482
Applications
WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.5% BSA, 0.05% Sodium Azide and 50% Glycerol.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R3H32
USP48 protects against myocardial ischemia-reperfusion injury by stabilizing and upregulating CNN1 in type 1 diabetes mice., PMID:40513941
Basal activation of ERK1/2 blunts the antimicrobial activity of neutrophils from aged hosts against antibody opsonized Streptococcus pneumoniae., PMID:40501583
The immunosuppressive effect of glucocorticoids in human primary T cells is mainly mediated via a rapid inhibition of the IL-2/IL-2R signaling axis., PMID:40468327
Siglec6 CAR T cells suppressed progression of AML via inhibiting Siglec6 and SHP2 induced Src and ERK signaling activation., PMID:40436895
PRL3-zumab as an anti-angiogenic therapy in neovascular eye diseases., PMID:40410189
Prolactin maintains the neonatal phenotype of enterocytes during lactation in newborn mice., PMID:40353577
Development and application of IgT monoclonal antibody in Nile tilapia Oreochromis niloticus., PMID:40345276
ERK2-mediated phosphorylation of ZEB1 at S322 enhances PD-L1 expression and EMT, leading to pancreatic cancer progression., PMID:40296122
E53, E96, D162, E247 and D322 in Ca2+-binding domains of annexin A2 are essential for regulating intracellular [Ca2+] and crystal adhesion to renal cells via ERK1/2 and JNK signaling pathways., PMID:40189002
BDNF secreted by mesenchymal stem cells improves aged oocyte quality and development potential by activating the ERK1/2 pathway., PMID:40122822
Zinc treatment prevents IgE-mediated Ca2+ influx and allergic response in RBL-2H3 cells., PMID:39971226
CXCL7 enhances RANKL-induced osteoclastogenesis via the activation of ERK/NFATc1 signaling pathway in inflammatory arthritis., PMID:39955597
Inhibition of Kinase Activity and In Vitro Downregulation of the Protein Kinases in Lung Cancer and Cervical Cancer Cell Lines and the Identified Known Anticancer Compounds of Ziziphus mucronata., PMID:39942957
Osteocyte connexin hemichannels and prostaglandin E2 release dictate bone marrow mesenchymal stromal cell commitment., PMID:39937859
β1 Integrin/FAK signaling regulates interleukin-8 production in human gingival epithelial Ca9-22 cells., PMID:39826873
ERK-USP9X-coupled regulation of thymidine kinase 1 promotes both its enzyme activity-dependent and its enzyme activity-independent functions for tumor growth., PMID:39824978
Design of Cell-Penetrating Domain Antibodies via a Genetically Encoded β-Lactam Amino Acid., PMID:39777952
The protein tyrosine phosphatase Lyp/PTPN22 drives TNFα-induced priming of superoxide anions production by neutrophils and arthritis., PMID:39724988
Action Mechanisms of Exosomes Derived from GD3/GD2-Positive Glioma Cells in the Regulation of Phenotypes and Intracellular Signaling: Roles of Integrins., PMID:39684463
Resolution of acute inflammation induced by monosodium urate crystals (MSU) through neutrophil extracellular trap-MSU aggregate-mediated negative signaling., PMID:39605016
IQGAP1 promotes early B cell development, is essential for the development of marginal zone (MZ) B cells, and is critical for both T-dependent and T-independent antibody responses., PMID:39585462
FGF8 Protects Against Polymicrobial Sepsis by Enhancing the Host's Anti-infective Immunity., PMID:39556487
Activation of mixed lineage kinase 3 by fine particulate matter induces skin inflammation in human keratinocytes., PMID:39547318
CD83 mediates the inhibitory effect of the S1PR1 agonist CYM5442 on LPS-induced M1 polarization of macrophages through the ERK-STAT-1 signaling pathway., PMID:39486189
Overcoming multiple barriers to deliver photo-gene system for glioma-targeted combined therapy., PMID:39426503
PARP1 acetylation at K119 is essential in regulating the progression and proliferation of cervical cancer cells., PMID:39400626
FUT6 Suppresses the Proliferation, Migration, Invasion, and Epithelial-Mesenchymal Transition of Esophageal Carcinoma Cells via the Epidermal Growth Factor Receptor/Extracellular Signal-Regulated Kinase Signaling Pathway., PMID:39375968
A phase 1b study of the ERK inhibitor MK-8353 plus pembrolizumab in patients with advanced solid tumors., PMID:39276176
Immunoglobulin-Mediated Cardiac Protection From Ischemia/Reperfusion Injury in Diabetic Rats Is Associated With Endothelial Nitric Oxide Synthase/Glucose Transporter-4 Signaling Pathway., PMID:39240727
Mdka produced by the activated HSCs drives bipotential progenitor cell redifferentiation during zebrafish biliary-mediated liver regeneration., PMID:39188045
LRG1 promotes atherosclerosis by inducing macrophage M1-like polarization., PMID:39178231
Neoplastic ICAM-1 protects lung carcinoma from apoptosis through ligation of fibrinogen., PMID:39168965
Intranasal LAG3 antibody infusion induces a rapid antidepressant effect via the hippocampal ERK1/2-BDNF signaling pathway in chronically stressed mice., PMID:39153731
Glypican-3 deficiency in liver cancer upregulates MAPK/ERK pathway but decreases cell proliferation., PMID:39113871
Syndecan-4 inhibition attenuates cartilage degeneration in temporomandibular joint osteoarthritis., PMID:39101668
Progesterone modulates cell growth via integrin αvβ3-dependent pathway in progesterone receptor-negative MDA-MB-231 cells., PMID:39071644
A Network-Based Framework to Discover Treatment-Response-Predicting Biomarkers for Complex Diseases., PMID:39067570
The BCR::ABL1 tyrosine kinase inhibitors ponatinib and nilotinib differentially affect endothelial angiogenesis and signalling., PMID:39009935
EGFR mutations induce the suppression of CD8+ T cell and anti-PD-1 resistance via ERK1/2-p90RSK-TGF-β axis in non-small cell lung cancer., PMID:39004699
A leukocyte immune-type receptor specific polyclonal antibody recognizes goldfish kidney leukocytes and activates the MAPK pathway in isolated goldfish kidney neutrophil-like cells., PMID:38997096
Stanniocalcin-2 expression in glioblastoma - A novel prognostic biomarker: An observational study., PMID:38996177
Tirbanibulin decreases cell proliferation and downregulates protein expression of oncogenic pathways in human papillomavirus containing HeLa cells., PMID:38967656
Equine Endothelial Cells Show Pro-Angiogenic Behaviours in Response to Fibroblast Growth Factor 2 but Not Vascular Endothelial Growth Factor A., PMID:38892205
Targeting ONECUT2 inhibits tumor angiogenesis via down-regulating ZKSCAN3/VEGFA., PMID:38797268
HHLA2 deficiency inhibits pancreatic cancer progression and THP-1 macrophage M2 polarization via EGFR/MAPK/ERK and mTOR/AKT pathway., PMID:38762741
The serine protease CORIN promotes progression of gastric cancer by mediating the ERK1/2 MAPK pathway., PMID:38751032
Infliximab modifies CD74-mediated lymphatic abnormalities and adipose tissue alterations in creeping fat of Crohn's disease., PMID:38713235
Asprosin aggravates atherosclerosis via regulating the phenotype transformation of vascular smooth muscle cells., PMID:38677690
Vesicular translocation of PARP-1 to cytoplasm causes ADP-ribosylation and disassembly of vimentin filaments during microglia activation induced by LPS., PMID:38590714
Treatment with onion bulb extract both prevents and reverses allergic inflammation in a murine model of asthma., PMID:38584568
For research use only. Not for human or drug use.
