Catalog No.
YHD33301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Phe80-Met215
Predicted molecular weight
17.53 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P19367
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Hexokinase type I, Hexokinase-1, HK1, Brain form hexokinase, Hexokinase-A, HK I
[Mechanism of vanillic acid against cardiac fibrosis induced by isoproterenol in mice based on Drp1/HK1/NLRP3 and mitochondrial apoptosis signaling pathways]., PMID:40461229
Resveratrol mitigates cold exposure-induced apoptosis and energy metabolism disorder in broiler heart by mediating the p38-PI3K/AKT-NF-κB axis., PMID:40460596
miR-181a-5p mediates the effects of BMP4 on intestinal cell proliferation and differentiation., PMID:40436833
Flavonoid derivative FB-15 inhibits the progression of nasopharyngeal carcinoma by targeting the PI3K-Akt signaling pathway., PMID:40409114
Disruption of ATR Signaling by Epstein-Barr Virus Latent Membrane Protein 1 Sensitizes Nasopharyngeal Carcinoma Cells to Cisplatin., PMID:40407079
ANKRD22 Induced by Transcription Factor MAZ Promotes Proliferation and Invasion of Nasopharyngeal Carcinoma., PMID:40346905
METTL3 mediates atheroprone flow-induced glycolysis in endothelial cells., PMID:40327688
The METTL14-YTHDF1-SAP30 Axis Promotes Glycolysis and Oxaliplatin Resistance in Colorectal Adenocarcinoma via m6A Modification., PMID:40289460
Serum Starvation-induced ROS Production Activates the ERK-AP-1-TfR1 Pathway to Up-regulate Survivin to Support Nasopharyngeal Carcinoma Cell Viability., PMID:40280716
Clinical manifestations of dual-gene variants involving ABCA4 in retinal dystrophies., PMID:40269797
UBL7 is indispensable for spermiogenesis through protecting critical factors from excessive degradation by proteasomes., PMID:40268954
Protein O-GlcNAcylation and hexokinase mitochondrial dissociation drive heart failure with preserved ejection fraction., PMID:40267914
CAPRIN1/TYMS/MTHFD2 axis promotes EMT process in nasopharyngeal carcinoma development., PMID:40246062
Astragaloside IV inhibits nasopharyngeal carcinoma progression by suppressing the SATB2/Wnt signaling axis., PMID:40177383
Whole-exome sequencing screening for candidate genes and potential pathogenic variants associated with early-onset high myopia in 47 Chinese families., PMID:40175531
[CEACAM6 inhibits proliferation and migration of nasopharyngeal carcinoma cells by suppressing epithelial-mesenchymal transition]., PMID:40159971
PI3Kβ functions as a protein kinase to promote cellular protein O-GlcNAcylation and acetyl-CoA production for tumor growth., PMID:40132583
Effects of chronic hypoxia on growth performance and nutrient metabolism in the tiger puffer, Takifugu rubripes., PMID:40132566
Gastrodin alleviates Aβ25-35-induced glycolytic dysfunction via activating PI3K/AKT/BACH1 signaling in Alzheimer's disease models., PMID:40127855
Structural and molecular dysfunctions in granulosa cells: A key contributor to porcine follicular atresia., PMID:40043493
Non-coding cis-regulatory variants in HK1 cause congenital hyperinsulinism with variable disease severity., PMID:40033430
5-hydroxymethylfurfural attenuates osteoarthritis by upregulating of glucose metabolism in chondrocytes., PMID:40020627
Development of attenuated Orf virus as a safe oncolytic viral vector for nasopharyngeal carcinoma treatment., PMID:40001231
Scutellarein enhances cisplatin‑induced apoptotic effects by suppressing the PI3K/AKT‑MDR1 pathway in human NPC/HK1 nasopharyngeal carcinoma cells., PMID:39991001
EBNA1 Targeted Ultra-Small Near-Infrared Persistent Luminescent Nano-Inhibitor for Theranostics of EBV-Associated Cancer., PMID:39972676
CircST6GALNAC6 Inhibits Glycolysis of Bladder Cancer by Regulating PRKN/HK1 Signaling Pathway., PMID:39960214
De-SUMO1ylated hexokinase 1 selectively degraded by ubiquitin-proteasome pathway promotes boar sperm capacitation in vitro., PMID:39952077
FTO-associated osteoclastogenesis promotes alveolar bone resorption in apical periodontitis male rat via the HK1/USP14/RANK pathway., PMID:39934129
Hexokinase-I directly binds to a charged membrane-buried glutamate of mitochondrial VDAC1 and VDAC2., PMID:39930004
TGF-β secreted by cancer cells-platelets interaction activates cancer metastasis potential by inducing metabolic reprogramming and bioenergetic adaptation., PMID:39895802
SENP1 inhibits aerobic glycolysis in Aβ1-42-incubated astrocytes by promoting PUM2 deSUMOylation., PMID:39794619
MCP5, a methyl-accepting chemotaxis protein regulated by both the Hk1-Rrp1 and Rrp2-RpoN-RpoS pathways, is required for the immune evasion of Borrelia burgdorferi., PMID:39775665
A Novel Pathogenic Sense Variant in Exon 7 of the HK1 Gene in a Patient with Hexokinase Deficiency and Gilbert Syndrome., PMID:39766843
Dynamin-Related Protein 1 Orchestrates Inflammatory Responses in Periodontal Macrophages via Interaction With Hexokinase 1., PMID:39762202
Genomic and transcriptomic profiling of radioresistant prostate and head and neck cancers implicate a BAHD1-dependent modification of DNA damage at the heterochromatin., PMID:39719436
miRNA‑22‑3p inhibits cell viability and metastasis of nasopharyngeal carcinoma by targeting FOXP1., PMID:39697977
Momordicine-I suppresses head and neck cancer growth by modulating key metabolic pathways., PMID:39696286
T. pallidum achieves immune evasion by blocking autophagic flux in microglia through hexokinase 2., PMID:39662785
Enhanced autophagy and cholesterol efflux in mouse mesenchymal stem cells infected with H37Rv compared to H37Ra., PMID:39653283
Anti-Inflammatory Effects of Cordyceps Cs-HK1 Fungus Exopolysaccharide on Lipopolysaccharide-Stimulated Macrophages via the TLR4/MyD88/NF-κB Pathway., PMID:39599671
Integrative analysis of non12-hydroxylated bile acid revealed the suppressed molecular map of alternative pathway in nonalcoholic steatohepatitis mice., PMID:39556333
Effects of dechlorane plus on hepatic pathology, metabolic health and gut microbiota in male mice., PMID:39551218
FOXA1 enhances antitumor immunity via repressing interferon-induced PD-L1 expression in nasopharyngeal carcinoma., PMID:39542656
The Role of PI3K/AKT/HIF-1α Pathway in the Effect of Nano-TiO2 on Lactate Production in TM4 Cells., PMID:39533807
Dependence of NPPS creates a targetable vulnerability in RAS-mutant cancers., PMID:39506063
Met-Flow analyses of the metabolic heterogeneity associated with different stages of cord blood-derived hematopoietic cell differentiation., PMID:39483465
D-mannose alleviates chronic periodontitis in rats by regulating the functions of neutrophils., PMID:39487474
Mendelian randomization and multi-omics approach analyses reveal impaired glucose metabolism and oxidative phosphorylation in visceral adipose tissue of women with polycystic ovary syndrome., PMID:39448886
DNA methylation-regulated HK1 overexpression contributes to irradiation-resistance by promoting glycolysis in non-small cell lung cancer., PMID:39417179
RABIF promotes hepatocellular carcinoma progression through regulation of mitophagy and glycolysis., PMID:39414994
For research use only. Not for human or drug use.
