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Anti-BCL2 Antibody (R3C09)

Catalog #:   RHC81007 Specific References (50) DATASHEET
Host species: Mouse
Isotype: IgG1
Applications: ELISA, FCM, WB
Accession: P10415
Overview

Catalog No.

RHC81007

Species reactivity

Human, Rat

Host species

Mouse

Isotype

IgG1

Clonality

Monoclonal

Applications

ELISA, FCM, WB

Recommended Dilution

Application Dilution
ELISA 1:10000, FCM: 1:200-1:400, WB: 1:500-1:2000

Target

Apoptosis regulator Bcl-2, BCL2

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P10415

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% Sodium Azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

R3C09

Note

For research use only.

Data Image
  • Flow Cytometry
    Flow cytometric analysis of THP-1 cells using BCL2 mouse mAb (green) and negative control (red).
  • Western blot
    Western blot analysis using BCL2 mouse mAb against Raji (1), MCF-7 (2), Jurkat (3), A549 (4), HEK293 (5), T47D (6), Hela (7), and C6 (8) cell lysate.
References

Sirt6 regulates the Notch signaling pathway and mediates autophagy and regulates podocyte damage in diabetic nephropathy., PMID:39754634

The association between NADPH oxidase (NOX) polymorphisms with immunohistochemistry and survival in diffuse large B cell lymphoma patients., PMID:39774928

Bcl-2 and galectin-3 expression is associated with recurrence of ameloblastoma., PMID:39802810

Therapeutic potential of brentuximab vedotin in breast cancer and lymphoma via targeted apoptosis and gene regulation., PMID:39805861

Phosphorylation of Bok at Ser-8 blocks its ability to suppress IP3R-mediated calcium mobilization., PMID:39810210

Targeting refractory diffuse large B cell lymphoma by CAR-WEE1 T-cells: In vitro evaluation., PMID:39820427

The challenge of targeting key drivers of CLL and sequencing therapy in an era of experimental therapeutics., PMID:39827471

Assessment of the level of apoptosis in differentiated pseudo-neuronal cells derived from neural stem cells under the influence of various inducers., PMID:39850017

Interaction of zinc oxide nanoparticles and nanorods with immunoglobulin G and underlying effects on MCF-7 breast cancer cells., PMID:39938843

Treatment of Relapsed/Refractory AML-Novel Treatment Options Including Immunotherapy., PMID:39960017

Basal Cell Carcinoma: A Digital Study of Immunohistochemical BCL2, P53 and CD138 Expression in Low- and High-Risk Types., PMID:40007456

The MURANO study: final analysis and retreatment/crossover substudy results of VenR for patients with relapsed/refractory CLL., PMID:40009494

Increased anti-apoptotic (Bcl-2+) and decreased proliferative (Ki-67+) cell fractions during the different maturation stages of bone marrow cell populations in MDS and AML: The potential diagnostic impact of the Bcl-2:Ki-67 ratio., PMID:40051252

Deciphering the IgG Idiotype Network Through Proteomic Analysis of Potential Targets in SARS-CoV-2-Induced Immune Responses., PMID:40077865

Waldenström Macroglobulinemia - A State-of-the-Art Review: Part 2- Focus on Therapy., PMID:40084099

The BCL2 family: from apoptosis mechanisms to new advances in targeted therapy., PMID:40113751

Diffuse large B-cell lymphoma with partial low Ki67 proliferation index., PMID:40138154

Potential role of liver-resident CD3+ macrophages in HBV clearance in a mouse hepatitis B model., PMID:40143948

Zanubrutinib plus R-CHOP improves the treatment effect of newly diagnosed diffuse large B cell lymphoma with double expression of MYC and BCL-2., PMID:40145086

[Update on marginal zone lymphoma classification, diagnosis and treatment in 2024]., PMID:40157832

Doubling down: the new deal in the clinical management of double-refractory chronic lymphocytic leukaemia., PMID:40209064

The Protective Effects of MSC-Derived Exosomes Against Chemotherapy-Induced Parotid Gland Cytotoxicity., PMID:40223864

Successful treatment of primary refractory DLBCL/HGBL - MYC/BCL2 transformed from FL using glofitamab: a case report., PMID:40230856

Long term follow-up of MRD guided treatment of Ibrutinib plus Venetoclax for Relapsed CLL: phase 2 VISION/HO141 trial., PMID:40249856

Evaluating Apoptotic Gene Efficiency for CHO Culture Performance Using Targeted Integration., PMID:40268279

Roles of GDF9 and BMP15 in equine follicular development: in vivo content and in vitro effects of IGF1 and cortisol on granulosa cells., PMID:40289073

In Silico Molecular Docking of 2-Hydroxyanthraquinone-Substituted Spiro-/Ansa Cyclotriphosphazenes: Targeting Apoptosis via Heat Shock Protein Modulation in Breast and Colon Cancer Cells., PMID:40296721

Chronic lymphocytic leukemia: what clinical progress have we seen in the last five years?, PMID:40314223

Overexpression of Tgm2 in Chinese Hamster Ovary Cells Enhances Recombinant Monoclonal Antibody Expression and Promotes Cell Proliferation through Reduction of Apoptosis., PMID:40327404

HIV-Tat upregulates the expression of senescence biomarkers in CD4+ T-cells., PMID:40342418

Phase II study of venetoclax added to bendamustine and obinutuzumab in patients with high-risk follicular lymphoma as front-line therapy: PrE0403., PMID:40355425

Buzhong Yiqi decoction improves inflammation and oxidative damage in autoimmune thyroiditis by inhibiting apoptosis via the SIRT1-Mediated Nrf2/NF-κB axis., PMID:40360040

Unraveling Venetoclax Resistance: Navigating the Future of HMA/Venetoclax-Refractory AML in the Molecular Era., PMID:40361510

Adult Acute Lymphoblastic Leukemia: 2025 Update on Diagnosis, Therapy, and Monitoring., PMID:40377367

Report of Consensus Panel 5 from the 12th International Workshop on Waldenström's Macroglobulinemia on the management of patients with intolerance or resistance to covalent BTK inhibitors., PMID:40379542

B cell receptor silencing reveals origin and dependencies of high-grade B cell lymphomas with MYC and BCL2 rearrangements., PMID:40402557

Genomic and Phenotypic Characterization of CHO 4BGD Cells with Quad Knockout and Overexpression of Two Housekeeping Genes That Allow for Metabolic Selection and Extended Fed-Batch Culturing., PMID:40422195

Revumenib for Relapsed or Refractory Acute Leukemia With a KMT2A Translocation., PMID:40437770

Co-targeting of epigenetic regulators and BCL-XL improves efficacy of immune checkpoint blockade therapy in multiple solid tumors., PMID:40442785

Hitting the Therapeutic Bullseye with Targeted Therapy for Patients with Chronic Lymphocytic Leukemia., PMID:40456120

Comparison of the Mutational Profile between BCL2- and BCL6-Rearrangement Positive Follicular Lymphoma., PMID:40482882

Comparative evaluation of a novel adhesive- Histoweld™ for immunohistochemistry: A non-inferiority study., PMID:40485404

Treatment of Older Adults with Newly Diagnosed Philadelphia Chromosome-Negative Acute Lymphoblastic Leukemia., PMID:40494331

Development of a Novel Biomarker Platform for Profiling Key Protein-Protein Interactions to Predict the Efficacy of BH3-Mimetic Drugs., PMID:40507334

Beyond BCL2 (B cell lymphoma) and BTK (Bruton tyrosine kinase) inhibitors: novel agents and resistance mechanisms for chronic lymphocytic leukemia., PMID:40515863

The anti-CD47 antibody magrolimab with obinutuzumab and venetoclax in relapsed or refractory indolent B-cell lymphomas., PMID:40524014

Tumor-Associated NK Cells Regulate Distinct CD8+ T-cell Differentiation Program in Cancer and Contribute to Resistance against Immune Checkpoint Blockers., PMID:40530506

Glofitamab Combined With Pola-R-CHP or R-CHOP as First Therapy in Younger Patients With High-Risk Large B-Cell Lymphoma: Results From the COALITION Study., PMID:40532125

Effects of Ganoderma spent substrate containing with polysaccharides and triterpenoids on the growth performance, antioxidant capacity and immunity level of chickens., PMID:40532998

Novel PI3kδ inhibitor roginolisib synergizes with venetoclax in hematologic malignancies., PMID:40534489

Datasheet

Document Download

Anti-BCL2 Antibody (R3C09).pdf

 

$ 220
Product specifications
50 μg 220 100 μg 350

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Anti-BCL2 Antibody (R3C09) [RHC81007]
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