Catalog No.
YHD32601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser1091-Leu1290
Predicted molecular weight
25.08 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P19174
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Phosphoinositide phospholipase C-gamma-1, PLC1, PLC-II, Phospholipase C-II, Phospholipase C-gamma-1, PLC-gamma-1, PLC-148, PLCG1, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
Network pharmacology and molecular docking-based characterization of the mechanisms through which Astragali Radix-Atractylodes macrocephala Koidz herb pair can treat membranous nephropathy., PMID:40489804
Cbl-b inhibitor NX-1607 activates MAPK/ERK signaling pathway and enhances T-cell activation., PMID:40447319
Difference Analysis of MiRNA Expression Profiles in Aged Female Rat Adipose Tissue Regulated by HIIT and MICT., PMID:40246773
A non-catalytic role of IPMK is required for PLCγ1 activation in T cell receptor signaling by stabilizing the PLCγ1-Sam68 complex., PMID:39478550
Impaired degradation of PLCG1 by chaperone-mediated autophagy promotes cellular senescence and intervertebral disc degeneration., PMID:39212196
PLCγ1 deficiency in chondrocytes accelerates the age-related changes in articular cartilage and subchondral bone., PMID:39159149
Neuromedin S regulates goat ovarian granulosa cell proliferation and steroidogenesis via endoplasmic reticulum Ca2+-YAP1-ATF4-c-Jun pathway., PMID:38982727
Identifying novel proteins for migraine by integrating proteomes from blood and CSF with genome-wide association data., PMID:38898596
Macrophage-derived FGFR1 drives atherosclerosis through PLCγ-mediated activation of NF-κB inflammatory signalling pathway., PMID:38842387
Human T-cell lymphotropic virus type 1 (HTLV-1) grip on T-cells: investigating the viral tapestry of activation., PMID:38734673
MiR-200c-3p as a novel genetic marker and therapeutic tool for alopecia areata., PMID:38454571
Feed-forward stimulation of CAMK2 by the oncogenic pseudokinase PEAK1 generates a therapeutically "actionable" signalling axis in triple negative breast cancer., PMID:38405732
Müller cells under hydrostatic pressure modulate retinal cell survival via TRPV1/PLCγ1 complex-mediated calcium influx in experimental glaucoma., PMID:38390745
Nuclear Binding Protein 2/Nesfatin-1 Affects Trophoblast Cell Fusion during Placental Development via the EGFR-PLCG1-CAMK4 Pathway., PMID:38339201
[Mutation characteristics of angioimmunoblastic T-cell lymphoma: an analysis of 75 cases]., PMID:38178743
Base-editing mutagenesis maps alleles to tune human T cell functions., PMID:38093011
Integrative bioinformatics analysis of biomarkers and pathways for exploring the mechanisms and molecular targets associated with pyroptosis in type 2 diabetes mellitus., PMID:38034011
Phospholipase C-γ as a Potential Therapeutic Target for Graves' Orbitopathy., PMID:37989267
PLCγ1 in dopamine neurons critically regulates striatal dopamine release via VMAT2 and synapsin III., PMID:37907739
BPTF Drives Gastric Cancer Resistance to EGFR Inhibitor by Epigenetically Regulating the C-MYC/PLCG1/Perk Axis., PMID:37863665
Extension domain of amyloid processor protein inhibits amyloidogenic cleavage and balances neural activity in a traumatic brain injury mouse model., PMID:37592823
Genome-Wide Acetylation Modification of H3K27ac in Bovine Rumen Cell Following Butyrate Exposure., PMID:37509173
SOCS1 as a Biomarker Candidate for HPV Infection and Prognosis of Head and Neck Squamous Cell Carcinomas., PMID:37504269
Exploring the potential common denominator pathogenesis of system lupus erythematosus with COVID-19 based on comprehensive bioinformatics analysis., PMID:37426642
A gain-of-function variation in PLCG1 causes a new immune dysregulation disease., PMID:37422272
Decoding the genetic relationship between Alzheimer's disease and type 2 diabetes: potential risk variants and future direction for North Africa., PMID:37342358
Comparisons of gene expression between peripheral blood mononuclear cells and bone tissue in osteoporosis., PMID:37335694
miR-218-5p and miR-320a-5p as Biomarkers for Brain Disorders: Focus on the Major Depressive Disorder and Parkinson's Disease., PMID:37329382
The influence of pyroptosis-related genes on the development of chronic obstructive pulmonary disease., PMID:37194062
Significance of pyroptosis-related gene in the diagnosis and classification of rheumatoid arthritis., PMID:37008939
Cell cycle, apoptosis, cell differentiation, and lipid metabolism gene expression in endometriotic tissue and exposure to parabens and benzophenones., PMID:37003176
Investigations of plausible pharmacodynamics supporting the antispasmodic, bronchodilator, and antidiarrheal activities of Berberis lycium Royle. Via in silico, in vitro, and in vivo studies., PMID:36587881
A frequent PLCγ1 mutation in adult T-cell leukemia/lymphoma determines functional properties of the malignant cells., PMID:36442790
Significant difference of differential expression pyroptosis-related genes and their correlations with infiltrated immune cells in sepsis., PMID:36250055
Meta-Analysis Identifies BDNF and Novel Common Genes Differently Altered in Cross-Species Models of Rett Syndrome., PMID:36232428
TLS/FUS-ERG fusion gene in acute leukemia and myelodysplastic syndrome evolved to acute leukemia: report of six cases and a literature review., PMID:36181538
Identification of a functional circRNA-miRNA-mRNA regulatory network in infantile hemangioma by bioinformatics analysis., PMID:36181115
The pyroptosis-related gene signature predicts prognosis and indicates the immune microenvironment status of chronic lymphocytic leukemia., PMID:36177050
Pyroptosis: a novel signature to predict prognosis and immunotherapy response in gliomas., PMID:36129672
Cardio-omentopexy requires a cardioprotective innate immune response to promote myocardial angiogenesis in mice., PMID:36004249
Mutations Affecting Genes in the Proximal T-Cell Receptor Signaling Pathway in Peripheral T-Cell Lymphoma., PMID:35954378
Methylation-mediated silencing of PTPRD induces pulmonary hypertension by promoting pulmonary arterial smooth muscle cell migration via the PDGFRB/PLCγ1 axis., PMID:35848503
Identification of a Novel Risk Model: A Five-Gene Prognostic Signature for Pancreatic Cancer., PMID:35845587
Dynamics of allosteric regulation of the phospholipase C-γ isozymes upon recruitment to membranes., PMID:35708309
Long-term disease control and safety with the anti-CCR4 antibody mogamulizumab: Post-hoc analyses from the MAVORIC trial of patients with previously treated cutaneous T-cell lymphoma., PMID:35695215
The Pyroptosis-Related Gene Prognostic Index Associated with Tumor Immune Infiltration for Pancreatic Cancer., PMID:35682857
Development of a Prognostic Model Based on Pyroptosis-Related Genes in Pancreatic Adenocarcinoma., PMID:35677632
Identification of the Pyroptosis-Related Prognosis Gene Signature and Immune Infiltration in Hepatocellular Carcinoma., PMID:35535333
SNCA correlates with immune infiltration and serves as a prognostic biomarker in lung adenocarcinoma., PMID:35421944
Extracellular vesicles derived from human umbilical cord mesenchymal stem cells relieves diabetic retinopathy through a microRNA-30c-5p-dependent mechanism., PMID:35367521
For research use only. Not for human or drug use.
