Catalog No.
YHD31501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr284-Ala633
Predicted molecular weight
41.29 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P18887
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
DNA repair protein XRCC1, XRCC1, X-ray repair cross-complementing protein 1
Parp1 deletion rescues cerebellar hypotrophy in xrcc1 mutant zebrafish., PMID:40379758
Joining of DNA breaks- interplay between DNA ligases and poly (ADP-ribose) polymerases., PMID:40347914
Genotype and Association of XRCC1 Gene With Liver Disease in Chronic Hcv Patients., PMID:40302092
PARP inhibitor response is enhanced in prostate cancer when XRCC1 expression is reduced., PMID:40271221
The drug discovery candidate for targeting PARP1 with Onosma. Dichroantha compounds in triple-negative breast cancer: A virtual screening and molecular dynamic simulation., PMID:40252254
Molecular dynamics simulations reveal R399Q mutation disrupts XRCC1-polβ interaction, potentially impairing DNA base excision repair pathway., PMID:40211828
The zinc finger of DNA Ligase 3α binds to nucleosomes via an arginine anchor., PMID:40162218
Repair pathway coordination from gap filling by polβ and subsequent nick sealing by LIG1 or LIG3α governs BER efficiency at the downstream steps., PMID:40081282
Association of XRCC gene family and CDH1 gene polymorphisms with gastric cancer risk in a Chinese population., PMID:40059436
Association of XRCC1 (rs1799782) and XPD (rs13181) gene polymorphisms with renal failure risk in a sample of Iraqi population: a case-control study., PMID:40056231
Genetic Navigation: A Narrative Review of XRCC1 Polymorphism Impact on Platinum-Based Chemotherapy Outcomes in NSCLC Patients., PMID:40034865
XRCC1 mediates PARP1- and PAR-dependent recruitment of PARP2 to DNA damage sites., PMID:39970298
Cancer prognosis using base excision repair genes., PMID:39828060
Parp1 deletion rescues cerebellar hypotrophy in xrcc1 mutant zebrafish., PMID:39803460
PARP1 inhibitor niraparib exerts synergistic antimyeloma effect with bortezomib through inducing DNA damage and inhibiting DNA repair., PMID:39736366
Genetic Polymorphisms of DNA Repair Genes and their Influence on Paclitaxel based Chemotherapy Induced Toxicity Reactions in Breast Cancer Patients., PMID:39733420
[DNA Methylation Profiling in Aneurysm and Comorbid Atherosclerosis of the Ascending Aorta]., PMID:39707852
Single-molecule studies of repair proteins in base excision repair., PMID:39701025
The association of rs25487 of the XRCC1 gene and rs13181 of the ERCC2 gene polymorphisms with the ovarian cancer risk., PMID:39699591
Search for germline gene variants in colorectal cancer families presenting with multiple primary colorectal cancers., PMID:39654522
APEX1 Polymorphisms Affect Acute Myeloid Leukemia Risk, and Its Expression Is Involved in Cell Proliferation and Differentiation., PMID:39536468
XRCC1 is linked to poor prognosis in adenocarcinoma of the esophagogastric junction after radiotherapy: transcriptome and alternative splicing events analysis., PMID:39527358
PARP1 condensates differentially partition DNA repair proteins and enhance DNA ligation., PMID:39496836
Epigenetic control of Topoisomerase 1 activity presents a cancer vulnerability., PMID:39484415
MRI-based radiogenomics analysis for predicting prognosis and XRCC1 gene polymorphism in pancreatic ductal adenocarcinoma., PMID:39487951
Investigation of the acute effect of the synthetic hemodialysis membrane on the expression of XRCC1 and PARP1 in chronic hemodialysis patients., PMID:39482820
Global screening of base excision repair in nucleosome core particles., PMID:39476546
Prognostic and Predictive Markers for Early Stage Triple-Negative Breast Cancer Treated With Platinum-Based Neoadjuvant Chemotherapy., PMID:39445528
Crosstalk between BER and NHEJ in XRCC4-Deficient Cells Depending on hTERT Overexpression., PMID:39408734
The flap endonuclease-1 mediated maturation of Okazaki fragments is critical for the cellular tolerance to remdesivir., PMID:39405747
CDK-dependent phosphorylation regulates PNKP function in DNA replication., PMID:39395804
Host repair polymorphisms and H. pylori genes in gastric disease outcomes: Who are the guardian and villains?, PMID:39389328
Mechanism of emodin in treating hepatitis B virus-associated hepatocellular carcinoma: network pharmacology and cell experiments., PMID:39346898
PINX1 loss confers susceptibility to PARP inhibition in pan-cancer cells., PMID:39174499
Dispensability of HPF1 for cellular removal of DNA single-strand breaks., PMID:39162207
XRCC1 and XPD polymorphisms: clinical outcomes and risk of prostate cancer in Bangladeshi population., PMID:39115699
Glycometabolic reprogramming-induced XRCC1 lactylation confers therapeutic resistance in ALDH1A3-overexpressing glioblastoma., PMID:39111285
Lactylation: Linking the Warburg effect to DNA damage repair., PMID:39111282
Redundant but essential functions of PARP1 and PARP2 in DNA ligase I-independent DNA replication., PMID:39106163
ATM and 53BP1 regulate alternative end joining-mediated V(D)J recombination., PMID:39083600
Semaglutide ameliorated autism-like behaviors and DNA repair efficiency in male BTBR mice by recovering DNA repair gene expression., PMID:39032854
DNA Repair Protein XRCC1 Stimulates Activity of DNA Polymerase λ under Conditions of Microphase Separation., PMID:39000034
Apurinic/apyrimidinic endonuclease 1 has major impact in prevention of suicidal covalent DNA-protein crosslink with apurinic/apyrimidinic site in cellular extracts., PMID:38963041
Unravelling the molecular tapestry of pterygium: insights into genes for diagnostic and therapeutic innovations., PMID:38907016
Association of XRCC1 p. Arg194Trp gene polymorphism with the risk of hepatocellular carcinoma in HCV Egyptian population: A pilot case-control study., PMID:38898405
Oncometabolite 2-hydroxyglutarate suppresses basal protein levels of DNA polymerase beta that enhances alkylating agent and PARG inhibition induced cytotoxicity., PMID:38897003
TRIM25-mediated XRCC1 ubiquitination accelerates atherosclerosis by inducing macrophage M1 polarization and programmed death., PMID:38896288
Feasibility of two-step approach for screening NTRK fusion in two major subtypes of non-small cell lung cancer within a large cohort., PMID:38866255
Multi-index comprehensive evaluation of the efficacy and response mechanism of immunotherapy in non-small cell lung cancer., PMID:38822977
The TIMELESS and PARP1 interaction suppresses replication-associated DNA gap accumulation., PMID:38801073
For research use only. Not for human or drug use.
