Catalog No.
YHD27701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Asn321
Predicted molecular weight
39.62 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P18031
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PTPN1, PTP-1B, Tyrosine-protein phosphatase non-receptor type 1, Protein-tyrosine phosphatase 1B, PTP1B
STAT3 Facilitates Super Enhancer Formation to Promote Fibroblast-To-Myofibroblast Differentiation by the Analysis of ATAC-Seq, RNA-Seq and ChIP-Seq., PMID:40464702
Insights into PTP1B inhibitors as antidiabetic agents: Current research and future perspectives., PMID:40460723
Dual Conjugation of Long- and Medium-Chain Fatty Acids to BimBH3 Peptide Yields Ultra Long-Acting Inhibitors of Intracellular PTPN1/2., PMID:40458949
Repurposing dual-C-prenylated flavonoids as potent allosteric inhibitors of PTP1B: Integrated phytochemical, enzymological, and in silico evidence., PMID:40449325
A Nanoenzyme-Sensitized Photoelectrochemical Biosensing Platform Integrated with a Two-Step Radical Polymerization Signal Amplification Strategy for Ultrasensitive Detection of PTP1B Activity., PMID:40389327
Protective Effects of Isolated Curcumin From Curcuma longa on Key Enzymes Involved in the Insulin Signaling Pathway and Digestive and Metabolic Enzymes Associated With Obesity, Type 2 Diabetes, and Hypertension., PMID:40376699
PTPN2 Negatively Regulates Macrophage Immune Responses and Cellular Bioenergetics., PMID:40344246
Comprehensive genetic analysis based on multi - omics reveals novel therapeutic targets for mitral valve prolapse and drug molecular dynamics simulation., PMID:40311696
Synthesis and profiling (in vitro and in silico) of the 6-methoxy/hydroxy substituted 7-acetyl-2-aryl-5-bromobenzofurans for antihyperglycemic, cytotoxic and antioxidant properties., PMID:40300448
9-Hexadecenoic acid inhibits the aggressiveness of gastric cancer via targeting PTPN1/FTH1 signaling., PMID:40279138
Glycosylation Modification Balances the Aqueous Solubility of Lipidated Peptides and Facilitates Their Biostability., PMID:40203200
Dual-enzyme inhibitor screening against α-glucosidase and PTP1B by hollow fibers in tandem with ultrafiltration., PMID:40155164
Rapid and cost-effective screening of therapeutic targets for isoquercitrin in insulin resistance using virtual methods and fiber SPR biosensing., PMID:40109543
Synergistic activity of nootropic herbs as potent therapeutics for Alzheimer's disease: A cheminformatics, pharmacokinetics, and system pharmacology approach., PMID:40034353
Discovery of novel oleanolic acid glycoside derivatives targeting PTP1B/PI3K/AKT signaling pathway for the treatment of breast cancer., PMID:40007349
Neuroprotective and antidiabetic lanostane-type triterpenoids from the fruiting bodies of Ganoderma theaecolum., PMID:39986700
Autoinflammatory encephalopathy due to PTPN1 haploinsufficiency: a case series., PMID:39986310
PTP1B AND ZONULIN FAILED TO PREDICT THE MODIFICATION OF MUSCLE MASS IN CRITICALLY ILL PATIENTS WITH SEPTIC SHOCK., PMID:39965626
Fatty acid conjugated BimBH3 analogues with d‑amino acid substitution as PTPN1 inhibitors with enhanced activity, biostability and orally available potency for the treatment of diabetes., PMID:39954610
Structurally diverse dammarane-derived triterpenoids from the twigs of Aglaia perviridis Hiern and their α-glucosidase and PTP1B inhibitory activities., PMID:39952576
Design, synthesis, molecular docking and anticancer activity evaluation of methyl salicylate based thiazoles as PTP1B inhibitors., PMID:39929933
Endothelial insulin resistance induced by adrenomedullin mediates obesity-associated diabetes., PMID:39913566
Roseoglobuloside A, a Novel Nonanolide, and Identification of Specialized Metabolites as hPTP1B1 - 400 Inhibitors from Mangrove-Dwelling Aspergillus spp., PMID:39870085
SERT-Deficient Mice Fed Western Diet Reveal Altered Metabolic and Pro-Inflammatory Responses of the Liver: A Link to Abnormal Behaviors., PMID:39862090
Pulsatilla saponin D inhibits invasion and metastasis of triple-negative breast cancer cells through multiple targets and pathways., PMID:39819723
Multi Targeted Activity of Cocculus hirsutus through Modulation of DPP-IV and PTP-1B Leading to Enhancement of Glucose Uptake and Attenuation of Lipid Accumulation., PMID:39760988
Semisynthesis of Nocarterphenyl A and Its Analogues., PMID:39730310
Allosteric regulation of the tyrosine phosphatase PTP1B by a protein-protein interaction., PMID:39723820
A versatile and automatic on-line screening method: Transverse diffusion of laminar flow profiles-based capillary electrophoresis for exploring PTP1B inhibitors in natural products., PMID:39708525
Inhibiting de novo lipogenesis identifies a therapeutic vulnerability in therapy-resistant colorectal cancer., PMID:39705849
KAHA ligation as a platform for the rapid discovery of Protein Tyrosine phosphatase 1B (PTP1B) inhibitors., PMID:39673878
Pharmacological PTP1B inhibition rescues motor learning, neuroinflammation, and hyperglycaemia in a mouse model of Alzheimer's disease., PMID:39672227
Does Metabolic Manager Show Encouraging Outcomes in Alzheimer's?: Challenges and Opportunity for Protein Tyrosine Phosphatase 1b Inhibitors., PMID:39655712
Exploring the Antiviral Potential of Artemisia annua Through JAK-STAT Pathway Targeting: A Network Pharmacology Approach., PMID:39598448
Enzyme (α-Glucosidase, α-Amylase, PTP1B & VEGFR-2) Inhibition and Cytotoxicity of Fluorinated Benzenesulfonic Ester Derivatives of the 5-Substituted 2-Hydroxy-3-nitroacetophenones., PMID:39595931
Allosteric inhibition of PTP1B by bromocatechol-chalcone derivatives., PMID:39561499
Cigarette smoke alters calcium flux to induce PP2A membrane trafficking and endothelial cell permeability., PMID:39543165
A novel fluorescent probe with Aggregation-Induced emission characteristics for PTP1B activity sensing and inhibitor screening., PMID:39520822
PTP1B Modulates Carotid Plaque Vulnerability in Atherosclerosis Through Rab5-PDGFRβ-Mediated Endocytosis Disruption and Apoptosis., PMID:39517122
A mechanism for hypoxia-induced inflammatory cell death in cancer., PMID:39506105
A switch from lysosomal degradation to secretory autophagy initiates osteogenic bone metastasis in prostate cancer., PMID:39497621
PTPN1/2 inhibition promotes muscle stem cell differentiation in Duchenne muscular dystrophy., PMID:39477543
PTP1B inhibitor alleviates deleterious septic lung injury through Src signaling., PMID:39453497
Circulating extracellular vesicle-carried PTP1B and PP2A phosphatases as regulators of insulin resistance., PMID:39422717
Multipartite Fluorogenic Sensors for Monitoring Tyrosine Phosphatase Activity., PMID:39406683
miR-210 as a therapeutic target in diabetes-associated endothelial dysfunction., PMID:39402703
Design, synthesis and enzymatic inhibition evaluation of novel 4-hydroxy Pd-C-Ⅲ derivatives as α-glucosidase and PTP1B dual-target inhibitors., PMID:39378828
Lanostane triterpenoids from Ganoderma calidophilum exhibit potent anti-tumor activity by inhibiting PTP1B., PMID:39341486
Spinal PTP1B Regulated NMDA Receptor-mediated Nociceptive Transmission and Peripheral Inflammation-induced Pain Sensitization., PMID:39322833
Structure-Agnostic Bioactivity-Driven Combinatorial Biosynthesis Reveals New Antidiabetic and Anticancer Triterpenoids., PMID:39297433
For research use only. Not for human or drug use.
