Catalog No.
RHB98604
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, FCM: 1:200-1:400, IHC: 1:200-1:1000
Target
Apo-E, Apolipoprotein E, APOE
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P02649
Applications
ELISA, FCM, IHC
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R2X96
Microglial pruning of glycinergic synapses disinhibits spinal PKCγ interneurons to drive pain hypersensitivity in mice., PMID:40531965
Unique lipid cargoes in APOE4 human brain-derived extracellular vesicles recruit cell adhesion molecules and promote tauopathy in Alzheimer's disease., PMID:40502793
Robust Serum Proteomic Signatures of APOE2., PMID:40501769
Anti-amyloid antibody equilibrium binding to Aβ aggregates from human Alzheimer disease brain., PMID:40475543
MRI protocols and sequences for amyloid-related imaging abnormalities monitoring in Alzheimer's disease patients treated with monoclonal antibodies., PMID:40466018
Biomimetic nanocomplexes loading with evolocumab and curcumin for synergistic anti-atherosclerosis therapy in ApoE-/- mice., PMID:40462197
Ertugliflozin attenuates atherosclerosis in nondiabetic ApoE-/- mice by upregulating ABCA1 and LDLR via the PPARγ/LXRα pathway., PMID:40419168
Visualization of Apolipoprotein E-Binding Amyloid Plaques in Postmortem Alzheimer's Disease Brains Using a Novel Fluorescent Probe THK-5320., PMID:40292539
Discovery of an ApoE4-targeted small-molecule SirT1 enhancer for the treatment of Alzheimer's disease., PMID:40269061
Active Immunization Using TRPM2 Peptide Vaccine Attenuates Atherosclerotic Progression in a Mouse Model of Atherosclerosis., PMID:40266108
Clinical efficacy of anti-amyloid antibodies in apolipoprotein E ε4 homozygotes: A Bayesian reanalysis of lecanemab and donanemab phase 3 results., PMID:40225236
Conformational features of guinea pig apolipoprotein E offer insights into functioning of human apolipoprotein E., PMID:40221014
A Quantitative Trait Locus for Reduced Microglial APOE Expression Associates with Reduced Cerebral Amyloid Angiopathy., PMID:40162256
Donanemab: Appropriate use recommendations., PMID:40155270
Generalizability of trial criteria on amyloid-lowering therapy against Alzheimer's disease to individuals with mild cognitive impairment or early Alzheimer's disease in the general population., PMID:40122980
Amyloid-Related Imaging Abnormalities With Donanemab in Early Symptomatic Alzheimer Disease: Secondary Analysis of the TRAILBLAZER-ALZ and ALZ 2 Randomized Clinical Trials., PMID:40063015
β-Amyloid Induces Microglial Expression of GPC4 and APOE Leading to Increased Neuronal Tau Pathology and Toxicity., PMID:40060520
Microglial mechanisms drive amyloid-β clearance in immunized patients with Alzheimer's disease., PMID:40050704
Effect of alirocumab on postprandial hyperlipidaemia in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled, cross-over trial., PMID:40045751
Exploring epidemiological risk factors for cerebral amyloid angiopathy: Considerations for monoclonal antibody therapy in people with Alzheimer's disease., PMID:40042470
GOLM1 Promotes Atherogenesis by Activating Macrophage EGFR-ERK Signaling Cascade., PMID:40026146
A nanovaccine for immune activation and prophylactic protection of atherosclerosis in mouse models., PMID:40025093
Evaluation of two plasma-based proteotyping assays against APOE ε4 genotyping in a memory clinic setting: The Gothenburg H70 Clinical Studies., PMID:39988952
Associations of Cerebrospinal Fluid Orexin-A, Alzheimer Disease Biomarkers, and Cognitive Performance., PMID:39957622
Proteomic evaluation of borosilicate hybrid sol-gel coatings with osteogenic, immunomodulatory and antibacterial properties., PMID:39956001
SEC62-dependent ER-phagy contributes to apelin-13/APJ-induced monocyte-vascular endothelial cell adhesion in atherosclerosis pathogenesis., PMID:39930135
The impact of apolipoprotein E, type ∊4 allele on Alzheimer's disease pathological biomarkers: a comprehensive post-mortem pilot-analysis., PMID:39913635
Alzheimer's Disease Diagnosis and Management in the Age of Amyloid Monoclonal Antibodies., PMID:39893023
Novel Role of Pin1-Cis P-Tau-ApoE Axis in the Pathogenesis of Preeclampsia and Its Connection with Dementia., PMID:39857613
Brain MRI volumetry and atrophy rating scales as predictors of amyloid status and eligibility for anti-amyloid treatment in a real-world memory clinic setting., PMID:39708177
Absence of platelet overactivation and thrombosis formation among patients with coronary atherosclerosis disease after vaccination against SARS-CoV-2., PMID:39640769
Identification of isoAsp7-Aβ as a major Aβ variant in Alzheimer's disease, dementia with Lewy bodies and vascular dementia., PMID:39625512
Role of STING Deficiency in Amelioration of Mouse Models of Lupus and Atherosclerosis., PMID:39605244
Linking Antibodies Against Apolipoprotein A-1 to Metabolic Dysfunction-Associated Steatohepatitis in Mice., PMID:39595946
Amyloid-Related Imaging Abnormalities (ARIA) in Clinical Trials of Gantenerumab in Early Alzheimer Disease., PMID:39556389
Perceptions of key informant neurologists before implementing anti-amyloid drugs in the Spanish departments of neurology., PMID:39497319
Current insights into apolipoprotein E and the immune response in Alzheimer's disease., PMID:39445515
Amyloid-β predominant Alzheimer's disease neuropathologic change., PMID:39417691
Low to moderate ethanol exposure reduces astrocyte-induced neuroinflammatory signaling and cognitive decline in presymptomatic APP/PS1 mice., PMID:39402264
Genome-wide association studies of COVID-19 vaccine seroconversion and breakthrough outcomes in UK Biobank., PMID:39384777
Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model., PMID:39353433
Japanese Subgroup Analyses from EMERGE and ENGAGE, Phase 3 Clinical Trials of Aducanumab in Patients with Early Alzheimer's Disease., PMID:39350371
Siglec-5 as a novel receptor mediates endothelial cells oxLDL transcytosis to promote atherosclerosis., PMID:39341359
COL6A6 Peptide Vaccine Alleviates Atherosclerosis through Inducing Immune Response and Regulating Lipid Metabolism in Apoe-/- Mice., PMID:39329770
Lost in translation: Inconvenient truths on the utility of mouse models in Alzheimer's disease research., PMID:39329365
Visualizing Immune Checkpoint Inhibitors Derived Inflammation in Atherosclerosis., PMID:39328090
Benefits and risks of FDA-approved amyloid-targeting antibodies for treatment of early Alzheimer's disease: Navigating clinician-patient engagement., PMID:39306695
18F-fluorodeoxyglucose PET-MR characterization of aortic inflammation in ApoE-/- mouse models of accelerated atherosclerosis: comparison of Western diet vs. uremia., PMID:39305349
For research use only. Not for human or drug use.
