Catalog No.
YHD25301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu45-Asp514
Predicted molecular weight
55.96 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P17655
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Calpain M-type, Calcium-activated neutral proteinase 2, CANPL2, Calpain-2 catalytic subunit, CAPN2, Calpain large polypeptide L2, Calpain-2 large subunit, Millimolar-calpain, M-calpain, CANP 2
In Silico Screening for Small Molecules to Alter Calpain Proteolysis through Modulating Conformation Changes Induced by Heterodimerization., PMID:40392912
Quantification and structure-function analysis of calpain-1 and calpain-2 protease subunit interactions., PMID:40383147
Repercussions of the Calpain Cleavage-Related Missense Mutations in the Cytosolic Domains of Human Integrin-β Subunits on the Calpain-Integrin Signaling Axis., PMID:40362482
N-terminomics and proteomics analysis of Calpain-2 reveal key proteolytic processing of metabolic and cell adhesion proteins., PMID:40277457
Oxytocin Anti-Apoptotic Potential Mediates Neuroprotection Against 3-Nitropropionic Acid-Induced Huntington's Disease-Like Pathophysiology in Rats: Involvement of Calpain-2/p25 Cdk5/MEF-2 Signaling Pathway., PMID:40252127
Human skeletal muscle possesses both reversible proteomic signatures and a retained proteomic memory after repeated resistance training., PMID:40183698
Inhibition of Aberrant Activated Fibroblast-Like Synoviocytes in Rheumatoid Arthritis by Leishmania Peptide via the Regulation of Fatty Acid Synthesis Metabolism., PMID:40125636
Terpinen-4-ol suppresses proliferation and motility of cutaneous squamous cell carcinoma cells by enhancing calpain-2 expression., PMID:40109860
ST3GAL1 regulates cancer cell migration through crosstalk between EGFR and neuropilin-1 signaling., PMID:40024474
Transcriptome and DNA methylation analyses provide insight into the heterosis of growth-related traits in hybrid yellow croaker., PMID:39939943
Calpain 2 regulates IL-1α secretion and inhibits tumor development via modulating calpain 1 expression in the tumor microenvironment., PMID:39803956
Identification of selective sweep and associated QTL traits in Iranian Ovis aries and Ovis orientalis populations., PMID:39748948
Calpain 2 promotes Lenvatinib resistance and cancer stem cell traits via both proteolysis-dependent and independent approach in hepatocellular carcinoma., PMID:39739077
Neutrophil elastase activates macrophage calpain as a mechanism for phagocytic failure., PMID:39499256
Comprehensive bioinformatics analysis of the prognostic value and immune infiltration of CAPN2 in pancreatic adenocarcinoma., PMID:39454972
METTL16 inhibits pancreatic cancer proliferation and metastasis by promoting MROH8 RNA stability and inhibiting CAPN2 expression - experimental studies., PMID:39434688
Transcriptome profiling of Canine Parvovirus 2 Nonstructural gene 1(CPV2.NS1) transfected 4T1 mice mammary tumor cells to elucidate its oncolytic effects., PMID:39419151
LncRNA FAISL Inhibits Calpain 2-Mediated Proteolysis of FAK to Promote Progression and Metastasis of Triple Negative Breast Cancer., PMID:39287113
Subcellular Fractionation and Metaproteogenomic Identification and Validation of Key Differentially Expressed Molecular Targets for Keloid Disease., PMID:39122141
Transcriptomic and Epigenomic Responses to Cortisol-Mediated Stress in Rainbow Trout (Oncorhynchus mykiss) Skeletal Muscle., PMID:39062828
Amentoflavone regulates the miR-124-3p/CAPN2 axis to promote mitochondrial autophagy in HCC cells., PMID:39050595
CircATF6 inhibits hepatocellular carcinoma progression by suppressing calreticulin-mediated Wnt/β-catenin signaling pathway., PMID:39004325
Targeting calpain-2-mediated junctophilin-2 cleavage delays heart failure progression following myocardial infarction., PMID:38960317
CAPN2 promotes apalutamide resistance in metastatic hormone-sensitive prostate cancer by activating protective autophagy., PMID:38844946
Complement Cascade 8 - Alpha and Calpain-2 in Extracellular Vesicles of Human Vitreous as Biomarkers of Infectious Endophthalmitis., PMID:38767905
CAPN2 correlates with insulin resistance states in PCOS as evidenced by multi-dataset analysis., PMID:38610028
CAPN2-responsive mesoporous silica nanoparticles: A promising nanocarrier for targeted therapy of pancreatic cancer., PMID:38589004
Phytol and α-Bisabolol Synergy Induces Autophagy and Apoptosis in A549 Cells and Additional Molecular Insights through Comprehensive Proteome Analysis via Nano LC-MS/MS., PMID:38415491
Gonadotropin upregulates intraovarian calpains-1 and -2 during ovarian follicular recruitment in the SD rat model., PMID:38402721
The neuronal transcription factor MEIS2 is a calpain-2 protease target., PMID:38305737
Identification and validation of plasma AGRN as a novel diagnostic biomarker of hepatitis B Virus-related chronic hepatitis and liver fibrosis/cirrhosis., PMID:38197199
Pt-Se-Bonded Nanoprobe for High-Fidelity Detection of Non-small Cell Lung Cancer and Enhancement of NIR II Photothermal Therapy., PMID:38051938
Different nutritional systems influence the tenderness and lipid oxidation of ewe lamb meat without altering gene expression., PMID:37909606
Identification of autophagy-related genes in diabetic foot ulcer based on bioinformatic analysis., PMID:37909396
Diagnostic and prognostic value of autophagy-related key genes in sepsis and potential correlation with immune cell signatures., PMID:37701780
Rare variants in CAPN2 increase risk for isolated hypoplastic left heart syndrome., PMID:37663545
Circular RNA circRILPL1 promotes nasopharyngeal carcinoma malignant progression by activating the Hippo-YAP signaling pathway., PMID:37173390
New panel of biomarkers to discriminate between amelanotic and melanotic metastatic melanoma., PMID:36776379
Muscle regeneration in gilthead sea bream: Implications of endocrine and local regulatory factors and the crosstalk with bone., PMID:36755925
Calpain-2 Facilitates Autophagic/Lysosomal Defects and Apoptosis in ARPE-19 Cells and Rats Induced by Exosomes from RPE Cells under NaIO3 Stimulation., PMID:36703913
Neurobiochemical, Peptidomic, and Bioinformatic Approaches to Characterize Tauopathy Peptidome Biomarker Candidates in Experimental Mouse Model of Traumatic Brain Injury., PMID:36635478
[Effect of extracellular signal-regulated kinase inhibitor on calpain in rat cerebral cortex after cardiopulmonary resuscitation]., PMID:36567566
An eleven autophagy-related genes-based prognostic signature for endometrial carcinoma., PMID:36210389
Sustained over-expression of calpain-2 induces age-dependent dilated cardiomyopathy in mice through aberrant autophagy., PMID:35986214
Identification of a novel Calpain-2-SRC feed-back loop as necessity for β-Catenin accumulation and signaling activation in hepatocellular carcinoma., PMID:35697802
Calpain-2 Mediates MBNL2 Degradation and a Developmental RNA Processing Program in Neurodegeneration., PMID:35606145
Cisplatin-induced pyroptosis is mediated via the CAPN1/CAPN2-BAK/BAX-caspase-9-caspase-3-GSDME axis in esophageal cancer., PMID:35525317
Use of AD Informer Set compounds to explore validity of novel targets in Alzheimer's disease pathology., PMID:35434254
Regulation of microtubule detyrosination by Ca2+ and conventional calpains., PMID:35373296
Methylated DNA markers for plasma detection of ovarian cancer: Discovery, validation, and clinical feasibility., PMID:35370009
For research use only. Not for human or drug use.
