Catalog No.
YHD24301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Tyr323
Predicted molecular weight
63.91 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P17516
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
3-alpha-HSD1, 3alpha-hydroxysteroid 3-dehydrogenase, DD4, Aldo-keto reductase family 1 member C4, AKR1C4, DD-4, CDR, HAKRA, Chlordecone reductase, 3-alpha-hydroxysteroid dehydrogenase type I, CHDR, Dihydrodiol dehydrogenase 4
Note
For research use only.
Polymorphisms in AKR1C4 and HSD3B2 and differences in serum DHEAS and progesterone are associated with paranoid ideation during mania or hypomania in bipolar disorder., PMID:22356824
Selective inhibition of human type-5 17β-hydroxysteroid dehydrogenase (AKR1C3) by baccharin, a component of Brazilian propolis., PMID:22506594
Selective inhibitors of aldo-keto reductases AKR1C1 and AKR1C3 discovered by virtual screening of a fragment library., PMID:22881866
Quantitative analysis of the human AKR family members in cancer cell lines using the mTRAQ/MRM approach., PMID:23544749
Role of aldo-keto reductase family 1 (AKR1) enzymes in human steroid metabolism., PMID:24189185
Genetic merit for fertility traits in Holstein cows: V. Factors affecting circulating progesterone concentrations., PMID:24952779
Fine mapping analysis confirms and strengthens linkage of four chromosomal regions in familial hypospadias., PMID:24986825
The role of carbonyl reducing enzymes in oxcarbazepine in vitro metabolism in man., PMID:25063510
In vitro metabolism of a novel JNK inhibitor tanzisertib: interspecies differences in oxido-reduction and characterization of enzymes involved in metabolism., PMID:25475995
Promiscuity and diversity in 3-ketosteroid reductases., PMID:25500069
Carbonyl-reducing enzymes as targets of a drug-immobilised affinity carrier., PMID:25595226
Gestational form of Selenium in Free-Choice Mineral Mixes Affects Transcriptome Profiles of the Neonatal Calf Testis, Including those of Steroidogenic and Spermatogenic Pathways., PMID:26043916
Synthesis of 8-hydroxy-2-iminochromene derivatives as selective and potent inhibitors of human carbonyl reductase 1., PMID:26068795
Impact of nonsynonymous single nucleotide polymorphisms on in-vitro metabolism of exemestane by hepatic cytosolic reductases., PMID:27111237
Local bone marrow renin-angiotensin system in the genesis of leukemia and other malignancies., PMID:27775788
Sex hormones reduce NNK detoxification through inhibition of short-chain dehydrogenases/reductases and aldo-keto reductases in vitro., PMID:28257955
Mefenamic acid enhances anticancer drug sensitivity via inhibition of aldo-keto reductase 1C enzyme activity., PMID:28259989
Reductive metabolism of tiaprofenic acid by the human liver and recombinant carbonyl reducing enzymes., PMID:28322780
Allopregnanolone levels and depressive symptoms during pregnancy in relation to single nucleotide polymorphisms in the allopregnanolone synthesis pathway., PMID:28666923
Long-chain fatty acids inhibit human members of the aldo-keto reductase 1C subfamily., PMID:28992312
Evaluation of the Effect of Uremic Serum on Hepatic Reductase Functional Expression., PMID:29658443
Carbonyl reduction of NNK by recombinant human lung enzymes: identification of HSD17β12 as the reductase important in (R)-NNAL formation in human lung., PMID:29788210
Blastocyst-induced changes in the bovine endometrial transcriptome., PMID:30021913
Characterization of a highly specific monoclonal antibody against human aldo-keto reductase AKR1C3., PMID:30639543
Role of human 3α-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C3) in the extrahepatic metabolism of the steroidal aromatase inactivator Formestane., PMID:31733346
Human dehydrogenase/reductase SDR family member 11 (DHRS11) and aldo-keto reductase 1C isoforms in comparison: Substrate and reaction specificity in the reduction of 11-keto-C19-steroids., PMID:31926269
Molecular genetic analysis of AKR1C2-4 and HSD17B6 genes in subjects 46,XY with hypospadias., PMID:32732174
Quantitative analysis of mRNA expression levels of aldo-keto reductase and short-chain dehydrogenase/reductase isoforms in human livers., PMID:33036882
Mining of RNA Methylation-Related Genes and Elucidation of Their Molecular Biology in Gallbladder Carcinoma., PMID:33718182
Interactions between exposure to polycyclic aromatic hydrocarbons and xenobiotic metabolism genes, and risk of breast cancer., PMID:34351578
Unravelling the role of 17β-estradiol on advancing uterine luteolytic cascade in cattle., PMID:34455235
The Impact of Age and Genetics on Naltrexone Biotransformation., PMID:34728519
Gene Expression Profiling of 1α,25(OH)2 D3 Treatment in 2D/3D Human Hepatocyte Models Reveals CYP3A4 Induction but Minor Changes in Other Xenobiotic-Metabolizing Genes., PMID:35184385
Cross-ancestry Genome-wide Association Studies of Sex Hormone Concentrations in Pre- and Postmenopausal Women., PMID:35192695
Porcine aldo-keto reductase 1C subfamily members AKR1C1 and AKR1C4: Substrate specificity, inhibitor sensitivity and activators., PMID:35398259
Preliminary Study on Gene Regulation and its Pathways in Chinese Holstein Cows with Clinical Mastitis Caused by Staphylococcus Aureus., PMID:35892111
Quantitative Evaluation of the Contribution of Each Aldo-Keto Reductase and Short-Chain Dehydrogenase/Reductase Isoform to Reduction Reactions of Compounds Containing a Ketone Group in the Human Liver., PMID:36310032
The prognosis of lipid reprogramming with the HMG-CoA reductase inhibitor, rosuvastatin, in castrated Egyptian prostate cancer patients: Randomized trial., PMID:36480560
Relevance of Human Aldoketoreductases and Microbial β-Glucuronidases in Testosterone Disposition., PMID:36623880
Blood transcriptome reveals immune and metabolic-related genes involved in growth of pasteurized colostrum-fed calves., PMID:36814903
Novel D-modified heterocyclic androstane derivatives as potential anticancer agents: Synthesis, characterization, in vitro and in silico studies., PMID:37451557
Quantitative Analysis of mRNA and Protein Expression Levels of Aldo-Keto Reductase and Short-Chain Dehydrogenase/Reductase Isoforms in the Human Intestine., PMID:37722844
Effects of 17β-estradiol on the uterine luteolytic cascade in bovine females at the end of diestrus., PMID:37783065
C-C motif chemokine ligand 2 regulates prostaglandin synthesis and embryo attachment of the bovine endometrium during implantation., PMID:38438567
Potential Molecular Markers for Cholecystic Inflammation-Induced Carcinogenesis Based on RNA-Seq Gene Screening., PMID:38716548
Identification of potential differences in salivary proteomic profiles between estrus and diestrus stage of estrous cycle in dairy cows., PMID:39008339
Unveiling the role of phytochemicals in autism spectrum disorder by employing network pharmacology and molecular dynamics simulation., PMID:39570464
Comparison of the impact of chlordecone and its metabolite chlordecol on genes involved in pesticide metabolism in HepG2 cell line., PMID:40252817
Inter-individual variability, differential tissue abundance, and sub-cellular localization of human aldo-keto reductases (AKRs) and hydroxy-steroid dehydrogenases (HSDs)., PMID:40484033
Heterocyclic androstane derivatives targeting hormone-related cancers: Synthesis, bioactivity and docking studies., PMID:40505260
For research use only. Not for human or drug use.
