Catalog No.
YHD22501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu3-Gln107
Predicted molecular weight
13.77 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P17096
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
HMGA1, High mobility group protein HMG-I/HMG-Y, High mobility group protein A1, HMGIY, High mobility group protein R, HMG-I(Y), High mobility group AT-hook protein 1
High mobility group A1 (HMGA1) promotes esophageal squamous cell carcinoma progression by inhibiting STING-mediated anti-tumor immunity., PMID:40456764
Unlocking the therapeutic potential of lncRNA FENDRR in DCM: novel targets and insights via the miR-296-5p/HMGA1 axis., PMID:40450345
CCL18 derived from M2-polarized tumor-associated macrophages promotes endometrial cancer progression by activating the TWIST1/HMGA1 axis., PMID:40353623
Aryl Hydrocarbon Receptor (AHR) Suppresses Arsenic (As3+)-Induced Malignant Transformation by Antagonizing TOX Expression., PMID:40303305
HMGA1 as a prognostic biomarker for gliomas: expression patterns, survival correlations, and clinical insights from a Pakistani cohort., PMID:40293672
NUDT16 enhances the resistance of cancer cells to DNA-damaging agents by regulating replication fork stability via reversing HMGA1 ADP-ribosylation., PMID:40288645
NUP62 alleviates senescence and promotes the stemness of human dental pulp stem cells via NSD2-dependent epigenetic reprogramming., PMID:40246825
Screening colorectal cancer associated autoantigens through multi-omics analysis and diagnostic performance evaluation of corresponding autoantibodies., PMID:40240912
HMGA1 deficiency: a pathogenic link between tau pathology and insulin resistance., PMID:40233659
Clinical efficacy and chemoresistance analysis of precision neoadjuvant chemotherapy for borderline resectable pancreatic cancer: a prospective, single-arm pilot study., PMID:40146255
RNA-binding protein expression based machine learning model predicts metastasis and treatment outcome of testicular cancer., PMID:40138122
Case Report and Literature Review: Overexpression of HMGA in Concomitant Plurihormonal Tumor and Papillary Thyroid Carcinoma., PMID:40114328
High Mobility Group A1 Chromatin Keys: Unlocking the Genome During MPN Progression., PMID:40076747
Complicated crosstalk between HMGA and non-coding RNAs modulates hallmarks of cancer., PMID:40055693
FOSL1 drives the malignant progression of pancreatic cancer cells by regulating cell stemness, metastasis and multidrug efflux system., PMID:40038751
The Role of HMGA1 and Height in Breast Cancer Risk and Prognosis: Insights from UK Biobank Data., PMID:40034958
Expanding the Molecular-genetic Spectrum of Canalicular Adenoma-like Subtype of Pleomorphic Adenoma of Salivary Glands., PMID:40033554
Exosome-transmitted LUCAT1 promotes stemness transformation and chemoresistance in bladder cancer by binding to IGF2BP2., PMID:40025525
Sigma-1 Receptor-Mediated High Mobility Group A1 Silencing Alleviates Endoplasmic Reticulum Stress-Induced Ovarian Granulosa Cell Apoptosis: An In Vitro Cell Experimental Study., PMID:39992005
[circ_0084043/miR-31-5p Is Involved in Atherosclerosis by Regulating HMGA1: Investigation of the Mechanisms]., PMID:39990843
A method for the identification of lactate metabolism-related prognostic biomarkers and its validations in non-small cell lung cancer., PMID:39962075
Study on the expression of S100A4 and HMGA1 in endometrial carcinoma and their correlation with metastasis., PMID:39959192
BANCR-containing extracellular vesicles enhance breast cancer resistance., PMID:39947472
HMGA1 is a crucial mediator of colon tumorigenesis driven by the loss of APC., PMID:39895631
HMGA1 acts as an epigenetic gatekeeper of ASCL2 and Wnt signaling during colon tumorigenesis., PMID:39895630
IGF2BP3 is upregulated in endometrial cancer and tightly regulates the growth of drug-resistant endometrial cancer cells via HMGA1., PMID:39878052
Receptor activity-modifying protein 1 regulates the differentiation of mouse skin fibroblasts by downregulating α-SMA expression via suppression of high mobility group AT-hook 1 to promote skin wound repair., PMID:39839760
Satellite DNA shapes dictate pericentromere packaging in female meiosis., PMID:39779853
HMGA1 Plays a Role in Counteracting DNA Damage Induced by BoHV-1 Productive Infection., PMID:39769030
Cross-species comparison reveals that Hmga1 reduces H3K27me3 levels to promote cardiomyocyte proliferation and cardiac regeneration., PMID:39747457
Sevoflurane Alleviates Myocardial Ischemia/Reperfusion Injury by Targeting the circ_CDR1as/miR-671-5p/HMGA1 Axis., PMID:39717931
HMGA1 influence on iron-induced cell death in Tfh cells of SLE patients., PMID:39707065
PARylation of HMGA1 desensitizes esophageal squamous cell carcinoma to olaparib., PMID:39690136
DEHP and Its Metabolite MEHP Alter the Insr and Glut4 Gene Expression by Blunting the Interaction of Transcription Factors in L6 Myotubes., PMID:39656169
TPR is required for cytoplasmic chromatin fragment formation during senescence., PMID:39625470
HMGA2 as a prognostic and immune biomarker in hepatocellular carcinoma: Comprehensive analysis of the HMG family and experiments validation., PMID:39591457
High mobility group A1 (HMGA1) promotes the tumorigenesis of colorectal cancer by increasing lipid synthesis., PMID:39548107
Hsa_circ_0048764 facilitates the progression of non-small cell lung cancer by targeting miR-1178-3p/HMGA1 axis., PMID:39461578
HMGA1 stimulates cancer stem-like features and sensitivity to monensin in gastric cancer., PMID:39293524
HMGA1 Regulates IRS2 to Promote Inflammatory Responses and Oxidative Stress Injury in MPP+-Induced cells., PMID:39244689
miR-196b-5p Affects Macrophage Polarization and Inflammation in Endometriosis., PMID:39243139
Organosulfur Compounds, S-Allyl-L-Cysteine and S-Ethyl-L-Cysteine, Target PCSK-9/LDL-R-Axis to Ameliorate Cardiovascular, Hepatic, and Metabolic Changes in High Carbohydrate and High Fat Diet-Induced Metabolic Syndrome in Rats., PMID:39225240
HMGA1 orchestrates chromatin compartmentalization and sequesters genes into 3D networks coordinating senescence heterogeneity., PMID:39134516
HMGA1 promotes the progression of esophageal squamous cell carcinoma by elevating TKT-mediated upregulation of pentose phosphate pathway., PMID:39080260
Survival-Related Genes on Chromosomes 6 and 17 in Medulloblastoma., PMID:39062749
Tall women with breast cancer have poorer survival than short women., PMID:39040191
Computing cell state discriminates the aberrant hematopoiesis and activated microenvironment in Myelodysplastic syndrome (MDS) through a single cell genomic study., PMID:39033303
The RP11-417E7.1/THBS2 signaling pathway promotes colorectal cancer metastasis by activating the Wnt/β-catenin pathway and facilitating exosome-mediated M2 macrophage polarization., PMID:39020380
NAT10 Promotes Prostate Cancer Growth and Metastasis by Acetylating mRNAs of HMGA1 and KRT8., PMID:38922788
For research use only. Not for human or drug use.
