Catalog No.
YHD19501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu930-Thr1152
Predicted molecular weight
27.96 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P16885
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PLC-gamma-2, Phosphoinositide phospholipase C-gamma-2, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2, PLC-IV, Phospholipase C-gamma-2, PLCG2, Phospholipase C-IV
Therapeutic targets for venous thromboemblism: proteome-wide mendelian randomization and colocalization analyses., PMID:40420090
PLCG2 modulates TREM2 expression and signaling in response to Alzheimer's disease pathology., PMID:40346446
Exosomes derived from human amniotic mesenchymal stem cells promotes angiogenesis in hUVECs by delivering novel miRNA N-194., PMID:40329179
Liangxue Qushi Zhiyang Decoction Inhibits Atopic Dermatitis in Mice via FcγR-Mediated Phagocytosis., PMID:40322063
Network-Based Integrative Analysis to Identify Key Genes and Corresponding Reporter Biomolecules for Triple-Negative Breast Cancer., PMID:40287845
UBE2N modulates osteoclast differentiation via BTK-PLCγ2-Ca2+ signaling pathway to promote osteoporosis., PMID:40220977
Case Report: de novo in-frame deletion in PLCG2 gene: a case report of B-cell lymphopenia, pulmonary bullae, and cutis laxa., PMID:40170866
Brain 5-hydroxymethylcytosine alterations are associated with Alzheimer's disease neuropathology., PMID:40121201
Proteomic Changes Associated With Endogenous FBXW7 Mutations in Moderately Differentiated Endometrial Cancer Cells Include Increased TROP2 and Galectin-3 Levels., PMID:40087851
Emerging Role of SH3BP2 as Regulator of Immune and Nonimmune Cells in Nephrotic Syndrome., PMID:39991193
Resistance mechanisms and approach to chronic lymphocytic leukemia after BTK inhibitor therapy., PMID:39972943
Acquired mutations in patients with relapsed/refractory CLL who progressed in the ALPINE study., PMID:39853273
Multiplex digital PCR enables sensitive detection of resistance to BTK inhibitors., PMID:39849159
Monoallelic expression can govern penetrance of inborn errors of immunity., PMID:39743591
Splice site and de novo variants can cause PLCG2-associated immune dysregulation with cold urticaria., PMID:39667583
The PLCG2 Inhibits Tumor Progression and Mediates Angiogenesis by VEGF Signaling Pathway in Clear Cell Renal Cell Carcinoma., PMID:39614428
In Silico Analysis of Non-Conventional Oxidative Stress-Related Enzymes and Their Potential Relationship with Carcinogenesis., PMID:39594421
Consistent genes associated with structural changes in clinical Alzheimer's disease spectrum., PMID:39554844
Alzheimer's disease-associated protective variant Plcg2-P522R modulates peripheral macrophage function in a sex-dimorphic manner., PMID:39487477
A guide to selecting high-performing antibodies for PLC-gamma-2 for use in Western Blot, immunoprecipitation and immunofluorescence., PMID:39429638
Rapid identification of primary atopic disorders (PAD) by a clinical landmark-guided, upfront use of genomic sequencing., PMID:39381601
EPO modified MSCs protects SH-SY5Y cells against ischemia/hypoxia-induced apoptosis via REST-dependent epigenetic remodeling., PMID:39370424
Characterisation of molecular mechanisms for PLCγ2 disease-linked variants., PMID:39313402
Genetic regulation of B cell receptor signaling pathway: Insights from expression quantitative trait locus analysis using a mixed model., PMID:39236423
PLCG2 variants in cherubism., PMID:39197752
PLCG2, A Regulator of Lung Adenocarcinoma Proliferation and Migration Associated with Immune Infiltration., PMID:39177130
Unraveling the molecular pathogenesis of Type 2 Diabetes and its impact on female infertility: A bioinformatics and systems biology approach., PMID:39116715
Methyltransferase DNMT3B promotes colorectal cancer cell proliferation by inhibiting PLCG2., PMID:39108206
In vivo vitamin D target genes interconnect key signaling pathways of innate immunity., PMID:39042613
TNFRSF11A variants contribute to systemic autoinflammatory diseases: A case series of 12 patients., PMID:39003954
Characterization of a Novel Pathogenic PLCG2 Variant Leading to APLAID Syndrome Responsive to a TNF Inhibitor., PMID:38965708
Differential NEUROD1, ASCL1, and POU2F3 Expression Defines Molecular Subsets of Bladder Small Cell/Neuroendocrine Carcinoma With Prognostic Implications., PMID:38964503
Early reappearance of intraclonal proliferative subpopulations in ibrutinib-resistant chronic lymphocytic leukemia., PMID:38914716
METTL3 regulates M6A methylation-modified EBV-pri-miR-BART3-3p to promote NK/T cell lymphoma growth., PMID:38880226
A Review of Resistance Mechanisms to Bruton's Kinase Inhibitors in Chronic Lymphocytic Leukemia., PMID:38791284
PARP1-DOT1L transcription axis drives acquired resistance to PARP inhibitor in ovarian cancer., PMID:38778348
Mutational profile in previously treated patients with chronic lymphocytic leukemia progression on acalabrutinib or ibrutinib., PMID:38754046
Clinical implications of CSF-ctDNA positivity in newly diagnosed diffuse large B cell lymphoma., PMID:38750139
Treatment patterns, clinical outcomes and gene mutation characteristics of hepatitis B virus-associated mantle cell lymphoma., PMID:38676394
Multi-phased Kinetics and Interaction of Protein Kinase Signaling in Glycoprotein VI-Induced Platelet αIIbβ3 Integrin Activation and Degranulation., PMID:38653482
POU2F3-positive small cell carcinoma of the bladder: A clinicopathologic analysis of 4 cases and literature review., PMID:38615507
Development of combination therapies with BTK inhibitors and dasatinib to treat CNS-infiltrating E2A-PBX1+/preBCR+ ALL., PMID:38598725
Synthetic Circular RNA for microRNA-1269a Suppresses Tumor Progression in Oral Squamous Cell Carcinoma., PMID:38539573
Reduced clone size upon BTK inhibitor resistance mutations relates to toxicity caused by inherited PLCG2 gain-of-function variations., PMID:38529725
In BTK, phosphorylated Y223 in the SH3 domain mirrors catalytic activity, but does not influence biological function., PMID:38507738
Single-cell RNA sequencing analysis of vestibular schwannoma reveals functionally distinct macrophage subsets., PMID:38480935
Spectrum of clinical phenotypes of PLCG2 gene variants: Just PLAID., PMID:38373474
PLCG2 and IFNAR1: The Potential Biomarkers Mediated by Immune Infiltration and Osteoclast Differentiation of Ankylosing Spondylitis in the Peripheral Blood., PMID:38223749
LCP1 knockdown in monocyte-derived macrophages: mitigating ischemic brain injury and shaping immune cell signaling and metabolism., PMID:38164159
Five-year follow-up of a phase 2 study of ibrutinib plus fludarabine, cyclophosphamide, and rituximab as initial therapy in CLL., PMID:38163317
For research use only. Not for human or drug use.
