Catalog No.
YHD18801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ile315-Met756
Predicted molecular weight
50.53 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P16615
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
SERCA2, Calcium pump 2, Sarcoplasmic/endoplasmic reticulum calcium ATPase 2, ATP2B, SR Ca(2+)-ATPase 2, Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform, ATP2A2, Endoplasmic reticulum class 1/2 Ca(2+) ATPase
RBFOX1 Regulates Calcium Signaling and Enhances SERCA2 Translation., PMID:40358188
[Analysis of clinical feature and genetic variant in a Chinese Han pedigree affected with Darier's disease]., PMID:40350400
ATP2A2 regulates STING1/MITA-driven signal transduction including selective autophagy., PMID:40265346
The gut microbiota metabolite trimethylamine N-oxide promotes cardiac hypertrophy by activating the autophagic degradation of SERCA2a., PMID:40210720
Identification of a molecular resistor that controls UCP1-independent Ca2+ cycling thermogenesis in adipose tissue., PMID:40199326
Subtherapeutic lithium supplementation causes physiological eccentric cardiac hypertrophy in young-adult wild-type male mice., PMID:40170524
Induction of MASH-like pathogenesis in the Nwd1-/- mouse liver., PMID:40069352
Severe Darier's Disease by Mitochondrial DNA Insertion Causing Nonsense Mutations: In Silico Prediction of a Pathophysiological Mechanism to a Novel Mutation., PMID:40062416
A case of multiple warty dyskeratomas overexpressing SERCA2 in acantholytic cells., PMID:40001339
Succinylation of SERCA2a at K352 Promotes Its Ubiquitinoylation and Degradation by Proteasomes in Sepsis-Induced Heart Dysfunction., PMID:39996319
Deficiency in nucleoside diphosphate kinase B leads to endothelial activation of the hexosamine biosynthesis pathway and cardiac dysfunction., PMID:39985023
Dominant rhabdomyolysis linked to a recurrent ATP2A2 variant reducing SERCA2 function in muscle., PMID:39970126
Androgen receptor alleviates doxorubicin-induced endoplasmic reticulum stress and myocardial injury by interacting with SERCA2a., PMID:39947494
SERCA2 dysfunction accelerates angiotensin II-induced aortic aneurysm and atherosclerosis by induction of oxidative stress in aortic smooth muscle cells., PMID:39884553
Effects of 8 Weeks of Moderate- or High-Volume Strength Training on Sarcoplasmic Reticulum Ca2+ Handling in Elite Female and Male Rowers., PMID:39831408
A Homozygous ATP2A2 Variant Alters Sarcoendoplasmic Reticulum Ca2+-ATPase 2 Function in Skeletal Muscle and Causes a Novel Vacuolar Myopathy., PMID:39817497
Inhibition of the upregulated phosphodiesterase 4D isoforms improves SERCA2a function in diabetic cardiomyopathy., PMID:39662482
Endoplasmic reticulum stress-related deficits in calcium clearance promote neuronal dysfunction that is prevented by SERCA2 gene augmentation., PMID:39615485
SERCA Modulators Reveal Distinct Signaling and Functional Roles of T Lymphocyte Ca2+ Stores., PMID:39596161
A novel ATP2A2 mutation in Darier and genotype phenotype: correlation analysis., PMID:39528793
Comparative Proteomic and Phosphoproteomic Analyses Reveal Molecular Signatures of Myocardial Infarction and Transverse Aortic Constriction in Aged Mouse Models., PMID:39502510
Alarin regulates RyR2 and SERCA2 to improve cardiac function in heart failure with preserved ejection fraction., PMID:39494460
Molecular determinants of skeletal muscle force loss in response to 5 days of dry immersion in human., PMID:39450600
Sacubitril/Valsartan Combination Partially Improves Cardiac Systolic, but Not Diastolic, Function through β-AR Responsiveness in a Rat Model of Type 2 Diabetes., PMID:39408945
Targeting SERCA2 in Anti-Tumor Drug Discovery., PMID:39323343
Hypoxia-responsive zinc finger E-box-binding homeobox 2 (ZEB2) regulates a network of calcium-handling genes in the injured heart., PMID:39308239
SARS-CoV-2 envelope protein alters calcium signaling via SERCA interactions., PMID:39261533
PKM2 regulates metabolic flux and oxidative stress in the murine heart., PMID:39256891
Pumping the Breaks on Acantholytic Skin Disorders: Targeting Calcium Pumps, Desmosomes, and Downstream Signaling in Darier, Hailey-Hailey, and Grover Disease., PMID:39207315
Deubiquitinase JOSD2 improves calcium handling and attenuates cardiac hypertrophy and dysfunction by stabilizing SERCA2a in cardiomyocytes., PMID:39195964
CASQ2 alleviates lung cancer by inhibiting M2 tumor-associated macrophage polarization and JAK/STAT pathway., PMID:39132772
Dantrolene corrects cellular disease features of Darier disease and may be a novel treatment., PMID:39060641
Successful treatment of Darier's disease with apremilast and review of reported cases., PMID:39031325
Perimenopause Decreases SERCA2a Activity in the Hearts of a Mouse Model of Ovarian Failure., PMID:38927078
Novel SERCA2 inhibitor Diphyllin displays anti-tumor effect in non-small cell lung cancer by promoting endoplasmic reticulum stress and mitochondrial dysfunction., PMID:38909775
Differential Downregulation of β1-Adrenergic Receptor Signaling in the Heart., PMID:38860414
Novel ATP2A2 Gene Mutation c.118G>A Causing Keratinocyte and Cardiomyocyte Disconnection in Darier Disease., PMID:38791022
Myocardial SERCA2 Protects Against Cardiac Damage and Dysfunction Caused by Inhaled Bromine., PMID:38772719
SERCA2 protects against cisplatin-induced damage of auditory cells: Possible relation with alleviation of ER stress., PMID:38688426
Mitochondrial carrier homolog 2 increases malignant phenotype of human gastric epithelial cells and promotes proliferation, invasion, and migration of gastric cancer cells., PMID:38577443
Compound SJ-12 attenuates streptozocin-induced diabetic cardiomyopathy by stabilizing SERCA2a., PMID:38548092
Persistent Cutaneous Lesions of Darier Disease and Second-Hit Somatic Variants in ATP2A2 Gene., PMID:38536168
Late-onset comedonal Darier disease with a novel frameshift mutation in ATP2A2., PMID:38465553
Protective effect of SERCA2a-SUMOylation by SUMO-1 on diabetes-induced atherosclerosis and aortic vascular injury., PMID:38438822
Identification of a novel nonsense ATP2A2 gene variant in a patient with Darier's disease flare following COVID-19 infection: A case report., PMID:38428853
The Effects of Aging on Sarcoplasmic Reticulum-Related Factors in the Skeletal Muscle of Mice., PMID:38396828
Rescuing SERCA2 pump deficiency improves bone mechano-responsiveness in type 2 diabetes by shaping osteocyte calcium dynamics., PMID:38291059
The protective effects of gallic acid and SGK1 inhibitor on cardiac damage and genes involved in Ca2+ homeostasis in an isolated heart model of ischemia/reperfusion injury in rat., PMID:38252301
Mosaic Darier disease flaring following allogeneic stem cell transplant., PMID:38225856
Early consequences of the phospholamban mutation PLN-R14del+/- in a transgenic mouse model., PMID:38214033
For research use only. Not for human or drug use.
