Catalog No.
YHD18301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr461-Ala597
Predicted molecular weight
17.51 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P16519
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PCSK2, Neuroendocrine convertase 2, KEX2-like endoprotease 2, NEC 2, PC2, Prohormone convertase 2, Proprotein convertase 2, NEC2
(-)-Oleuropein as a Novel Metastatic Castration-Resistant Prostate Cancer Progression and Recurrence Suppressor via Targeting PCSK9-LDLR Axis., PMID:40362754
Modeling diabetic alpha cell dysfunction using stem cell-derived alpha cells., PMID:40345205
Identification of Novel Genetic Variants and Food Intake Factors Associated with Type 2 Diabetes in South Korean Adults, Using an Illness-Death Model., PMID:40141237
Detection of structural variants linked to mutton flavor and odor in two closely related black goat breeds., PMID:39425017
PCSK2 can be Useful in a Panel Approach to Distinguish Foregut and Midgut Neuroendocrine Tumors., PMID:39034588
Suppressive action of nesfatin-1 and nesfatin-1-like peptide on cortisol synthesis in human adrenal cortex cells., PMID:38368491
Association of common variants of TCF7L2 and PCSK2 with gestational diabetes mellitus in West Bengal, India., PMID:37610142
CFTR and PC2, partners in the primary cilia in autosomal dominant polycystic kidney disease., PMID:37519231
Role of SNAP25 on the occurrence and development of eosinophilic gastritis., PMID:37478220
Tissue-Specific Modulation of Gluco- and Growth-Regulatory Factor Abundance by Nesfatin-1 and Nesfatin-1-like Peptide in Goldfish., PMID:37174474
Identification of an Immune-Related Gene Signature Associated with Prognosis and Tumor Microenvironment in Esophageal Cancer., PMID:36588538
Replication Activities of Major 5' Terminally Deleted Group-B Coxsackievirus RNA Forms Decrease PCSK2 mRNA Expression Impairing Insulin Maturation in Pancreatic Beta Cells., PMID:36560784
Reference Genes across Nine Brain Areas of Wild Type and Prader-Willi Syndrome Mice: Assessing Differences in Igfbp7, Pcsk1, Nhlh2 and Nlgn3 Expression., PMID:35955861
Hypothalamic CREB Regulates the Expression of Pomc-Processing Enzyme Pcsk2., PMID:35805082
Polycystin-2 (PC2) is a key determinant of in vitro myogenesis., PMID:35675637
Hypergastrinemia, a clue leading to the identification of an atypical form of diabetes mellitus type 2., PMID:35623402
Proteins and proteases of Prader-Willi syndrome: a comprehensive review and perspectives., PMID:35621394
Common variants in genes involved in islet amyloid polypeptide (IAPP) processing and the degradation pathway are associated with T2DM risk: A Chinese population study., PMID:35131375
Dense core vesicle markers in CSF and cortical tissues of patients with Alzheimer's disease., PMID:34565482
Depletion of Alpha-Melanocyte-Stimulating Hormone Induces Insatiable Appetite and Gains in Energy Reserves and Body Weight in Zebrafish., PMID:34440144
Obesity, POMC, and POMC-processing Enzymes: Surprising Results From Animal Models., PMID:34333593
A survey of the mouse hindbrain in the fed and fasted states using single-nucleus RNA sequencing., PMID:33962048
Prenatal testosterone triggers long-term behavioral changes in male zebra finches: unravelling the neurogenomic mechanisms., PMID:33676394
PCSK2 expression in neuroendocrine tumors points to a midgut, pulmonary, or pheochromocytoma-paraganglioma origin., PMID:32794589
Low concentration IL-1β promotes islet amyloid formation by increasing hIAPP release from humanised mouse islets in vitro., PMID:32728889
Revisiting Proinsulin Processing: Evidence That Human β-Cells Process Proinsulin With Prohormone Convertase (PC) 1/3 but Not PC2., PMID:32291281
Hippocampal changes in mice lacking an active prohormone convertase 2., PMID:32057164
Pax4 synergistically acts with Pdx1, Ngn3 and MafA to induce HuMSCs to differentiate into functional pancreatic β-cells., PMID:31572507
Expression of glucocorticoid and mineralocorticoid receptor genes co-varies with a stress-related colour signal in barn owls., PMID:31323230
Why don't corticotroph tumors always produce Cushing's disease?, PMID:31319379
Effects of Naltrexone on Energy Balance and Hypothalamic Melanocortin Peptides in Male Mice Fed a High-Fat Diet., PMID:30820484
Forms of selenium in vitamin-mineral mixes differentially affect the expression of genes responsible for prolactin, ACTH, and α-MSH synthesis and mitochondrial dysfunction in pituitaries of steers grazing endophyte-infected tall fescue., PMID:30476104
Enhanced mitochondrial pyruvate transport elicits a robust ROS production to sensitize the antitumor efficacy of interferon-γ in colon cancer., PMID:30439686
Changes in insulin, glucagon and ER stress precede immune activation in type 1 diabetes., PMID:30139929
Conventional and Neo-antigenic Peptides Presented by β Cells Are Targeted by Circulating Naïve CD8+ T Cells in Type 1 Diabetic and Healthy Donors., PMID:30078552
Genome-wide association studies for diabetic macular edema and proliferative diabetic retinopathy., PMID:29739359
Inhibition of the Mitochondrial Pyruvate Carrier by Tolylfluanid., PMID:29126303
Enteroendocrine K and L cells in healthy and type 2 diabetic individuals., PMID:28956082
Persistence of Pancreatic Insulin mRNA Expression and Proinsulin Protein in Type 1 Diabetes Pancreata., PMID:28877460
Polycystin 2-dependent cardio-protective mechanisms revealed by cardiac stress., PMID:28762163
The beneficial metabolic effects of insulin sensitizers are not attenuated by mitochondrial pyruvate carrier 2 hypomorphism., PMID:28597936
Impact of BRAF kinase inhibitors on the miRNomes and transcriptomes of melanoma cells., PMID:28408301
Whole Genome Expression Analysis in a Mouse Model of Tauopathy Identifies MECP2 as a Possible Regulator of Tau Pathology., PMID:28367114
Sequential Immunoprecipitation of Secretory Vesicle Proteins from Biosynthetically Labelled Cells., PMID:28353232
FAM3D inhibits glucagon secretion via MKP1-dependent suppression of ERK1/2 signaling., PMID:28247283
MC1R variants affect the expression of melanocortin and melanogenic genes and the association between melanocortin genes and coloration., PMID:27664794
Mitochondrial Pyruvate Import Promotes Long-Term Survival of Antibody-Secreting Plasma Cells., PMID:27396958
Molecular Mechanisms of Toxicity and Cell Damage by Chemicals in a Human Pancreatic Beta Cell Line, 1.1B4., PMID:27253232
Prohormone convertase 2 (PC2) null mice have increased mu opioid receptor levels accompanied by altered morphine-induced antinociception, tolerance and dependence., PMID:27208618
The Role of ARX in Human Pancreatic Endocrine Specification., PMID:26633894
For research use only. Not for human or drug use.
