Catalog No.
RHA41603
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Applications
FCM, IF, WB
Recommended Dilution
| Application |
Dilution |
| FCM |
1:200-1:400, IF: 1:200-1:1000, WB: 1:500-1:2000 |
Target
IKK-A, I-kappa-B kinase alpha, Transcription factor 16, TCF-16, CHUK, NFKBIKA, Inhibitor of nuclear factor kappa-B kinase subunit alpha, IKKA, TCF16, Nuclear factor NF-kappa-B inhibitor kinase alpha, I-kappa-B kinase 1, Conserved helix-loop-helix ubiquitous kinase, IKK1, IkappaB kinase, IKK-alpha, IkBKA
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
O15111
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R2U34
Note
For research use only.
The presentation and natural history of immunodeficiency caused by nuclear factor kappaB essential modulator mutation., PMID:15100680
Immunoregulation of dendritic cells by IL-10 is mediated through suppression of the PI3K/Akt pathway and of IkappaB kinase activity., PMID:15113757
Nuclear factor-inducing kinase plays a crucial role in osteopontin-induced MAPK/IkappaBalpha kinase-dependent nuclear factor kappaB-mediated promatrix metalloproteinase-9 activation., PMID:15247285
Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor-kappaB signaling., PMID:15252836
Proteome analysis of lipid rafts in Jurkat cells characterizes a raft subset that is involved in NF-kappaB activation., PMID:15253425
Gamma-interferon enhances expression of CD14/MyD88 and subsequent responsiveness to lipopolysaccharide from Actinobacillus actinomycetemcomitans in human gingival fibroblasts., PMID:15324355
Molecular analysis of a large cohort of patients with the hyper immunoglobulin M (IgM) syndrome., PMID:15358621
Tumor necrosis factor-like weak inducer of apoptosis-induced neurodegeneration., PMID:15385607
Identification of hypoxia-regulated proteins in head and neck cancer by proteomic and tissue array profiling., PMID:15492250
Negative regulation of JNK signaling by the tumor suppressor CYLD., PMID:15496400
The molecular adapter Carma1 controls entry of IkappaB kinase into the central immune synapse., PMID:15520247
Stress-induced inhibition of the NF-kappaB signaling pathway results from the insolubilization of the IkappaB kinase complex following its dissociation from heat shock protein 90., PMID:15611262
Peripheral lipopolysaccharide induces apoptosis in the murine olfactory bulb., PMID:15781053
Inhibition of IKK down-regulates antigen + IgE-induced TNF production by mast cells: a role for the IKK-IkappaB-NF-kappaB pathway in IgE-dependent mast cell activation., PMID:15784689
NEMO mutations in 2 unrelated boys with severe infections and conical teeth., PMID:15833888
B cell receptor (BCR) cross-talk: CD40 engagement creates an alternate pathway for BCR signaling that activates I kappa B kinase/I kappa B alpha/NF-kappa B without the need for PI3K and phospholipase C gamma., PMID:15879100
alpha3beta1 integrin induced suppression of the Caco-2 epithelial cell IL-1 signaling pathway leading to NF-(kappa)B activation., PMID:15919367
Inverse regulation of the nuclear factor-kappaB binding to the p53 and interleukin-8 kappaB response elements in lesional psoriatic skin., PMID:15955105
B-1 cells are deficient in Lck: defective B cell receptor signal transduction in B-1 cells occurs in the absence of elevated Lck expression., PMID:15972627
Alpha-lipoic acid inhibits TNF-alpha induced NF-kappa B activation through blocking of MEKK1-MKK4-IKK signaling cascades., PMID:18182252
Lung transplantation in Hong Kong: 12 years of experience., PMID:18811889
ATM mediates constitutive NF-kappaB activation in high-risk myelodysplastic syndrome and acute myeloid leukemia., PMID:19079347
Activation of endothelial intrinsic NF-{kappa}B pathway impairs protein C anticoagulation mechanism and promotes coagulation in endotoxemic mice., PMID:19620400
Resistin up-regulates COX-2 expression via TAK1-IKK-NF-kappaB signaling pathway., PMID:19774455
Association between anti-tumour necrosis factor treatment response and genetic variants within the TLR and NF{kappa}B signalling pathways., PMID:20448286
Mechanisms of the apoptosis induced by CD176 antibody in human leukemic cells., PMID:21455576
Lipopolysaccharide enhances decorin expression through the Toll-like receptor 4, myeloid differentiating factor 88, nuclear factor-kappa B, and mitogen-activated protein kinase pathways in odontoblast cells., PMID:22414830
Proteomic (antibody microarray) exploration of the molecular mechanism of action of the specific COX-2 inhibitor DuP 697., PMID:23338544
Lack of association of variants previously associated with anti-TNF medication response in rheumatoid arthritis patients: results from a homogeneous Greek population., PMID:24040234
Replication of PTPRC as genetic biomarker of response to TNF inhibitors in patients with rheumatoid arthritis., PMID:25896535
Conditional Deletion of NF-κB-Inducing Kinase (NIK) in Adult Mice Disrupts Mature B Cell Survival and Activation., PMID:26116508
Palliative care for a patient with Lambert-Eaton myasthenic syndrome: role of 3,4-diaminopyridine., PMID:27506750
Pharmacogenetics of ustekinumab in patients with moderate-to-severe plaque psoriasis., PMID:27977334
U.S. FDA Approval Summary: Nivolumab for Treatment of Unresectable or Metastatic Melanoma Following Progression on Ipilimumab., PMID:28087644
FDA Approval Summary: Accelerated Approval of Pembrolizumab for Second-Line Treatment of Metastatic Melanoma., PMID:28235882
Patients with melanoma treated with an anti-PD-1 antibody beyond RECIST progression: a US Food and Drug Administration pooled analysis., PMID:29361469
Novel heterozygous pathogenic variants in CHUK in a patient with AEC-like phenotype, immune deficiencies and 1q21.1 microdeletion syndrome: a case report., PMID:29523099
GNAI1 and GNAI3 Reduce Colitis-Associated Tumorigenesis in Mice by Blocking IL6 Signaling and Down-regulating Expression of GNAI2., PMID:30836096
Serological diagnosis of Mycobacterium avium complex lung diseases by enzyme immunoassay of IgA antibodies against MAC-specific glycopeptidolipid core antigen., PMID:32995571
Autophagic feedback-mediated degradation of IKKα requires CHK1- and p300/CBP-dependent acetylation of p53., PMID:33097607
Anti-tumour necrosis factor-alpha response associated with combined CD226 and HLA-DRB1[*]0404 haplotype in rheumatoid arthritis., PMID:33427622
FDA Approval Summary: Nivolumab Plus Ipilimumab for the Treatment of Patients with Hepatocellular Carcinoma Previously Treated with Sorafenib., PMID:33973307
Humanized anti‑TLR4 monoclonal antibody ameliorates lipopolysaccharide‑related acute kidney injury by inhibiting TLR4/NF‑κB signaling., PMID:34184086
Therapeutic effects of quinine in a mouse model of atopic dermatitis., PMID:34240224
FDA Approval Summary: Pembrolizumab, Atezolizumab, and Cemiplimab-rwlc as Single Agents for First-Line Treatment of Advanced/Metastatic PD-L1-High NSCLC., PMID:35101885
Need for aligning the definition and reporting of cytokine release syndrome (CRS) in immuno-oncology clinical trials., PMID:35219582
NF-ΚB Activation as a Key Driver in Chronic Lymphocytic Leukemia Evolution to Richter's Syndrome: Unraveling the Influence of Immune Microenvironment Dynamics., PMID:39596634
Assessment of Unexpected (Non-ABO) Red Blood Cell Antibodies and Their Associated Clinical Conditions Among Patients and Blood Donors Attending University Teaching Hospital of Kigali (CHUK) and Rwanda Blood Transfusion Division., PMID:40151361
Emerging Strategies and Progress in the Medical Management of Marburg Virus Disease., PMID:40333077
Marburg virus disease in Rwanda: an observational study of the first 10 days of outbreak response, clinical interventions, and outcomes., PMID:40394565
For research use only. Not for human or drug use.
