Catalog No.
RHA30603
Species reactivity
Human
Host species
Mouse
Isotype
IgG2b
Clonality
Monoclonal
Tested applications
ELISA: 1:10000, IHC: 1:200-1:1000
Target
GDF-8, GDF8, MSTN, Myostatin, Growth/differentiation factor 8
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
O14793
Applications
ELISA, IHC
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R2T98
Development and Potent Anti-Tumor Activity of a Fully Humanized Anti-TAG-72-IL-2 Fusion Protein for Therapy of Solid Tumors., PMID:40361381
GDF8 and activin A are the key negative regulators of muscle mass in postmenopausal females: a randomized phase I trial., PMID:40360471
Maternal Health and Safety Outcomes of Prenatal Myostatin Inhibition in Osteogenesis Imperfecta Mice., PMID:40305766
Effects of maternal antibodies against myostatin on post-hatch chicken growth and muscle mass in Sentul Indonesian indigenous chicken., PMID:40182813
Simultaneous detection of myostatin-targeting monoclonal antibodies in dried blood spots and plasma using liquid chromatography-tandem mass spectrometry with field asymmetric ion mobility spectrometry., PMID:39405785
Genetically engineering of Saccharomyces cerevisiae for enhanced oral delivery vaccine vehicle., PMID:38316348
GDF8 inhibition enhances musculoskeletal recovery and mitigates posttraumatic osteoarthritis following joint injury., PMID:38019905
Chloroplast transformation for bioencapsulation and oral delivery using the immunoglobulin G fragment crystallizable (Fc) domain., PMID:37919321
Circulating GDF11 exacerbates myocardial injury in mice and associates with increased infarct size in humans., PMID:37742057
Whole-Body Metabolism and the Musculoskeletal Impacts of Targeting Activin A and Myostatin in Severe Osteogenesis Imperfecta., PMID:37457877
Maternal immunization against myostatin suppresses post-hatch chicken growth., PMID:36201511
The Impact of Curcumin on Growth Performance, Growth-Related Gene Expression, Oxidative Stress, and Immunological Biomarkers in Broiler Chickens at Different Stocking Densities., PMID:35454205
Combinatorial Inhibition of Myostatin and Activin A Improves Femoral Bone Properties in the G610C Mouse Model of Osteogenesis Imperfecta., PMID:35195284
Role of Myostatin in Muscle Degeneration by Random Positioning Machine Exposure: An in vitro Study for the Treatment of Sarcopenia., PMID:35185612
Understanding of sarcopenia: from definition to therapeutic strategies., PMID:34537916
RANKL Mediates Muscle Atrophy and Dysfunction in a Cigarette Smoke-induced Model of Chronic Obstructive Pulmonary Disease., PMID:33689672
Salinity, Temperature and Ammonia Acute Stress Response in Seabream (Sparus aurata) Juveniles: A Multidisciplinary Study., PMID:33419050
The Failed Clinical Story of Myostatin Inhibitors against Duchenne Muscular Dystrophy: Exploring the Biology behind the Battle., PMID:33322031
Impact of Genetic and Pharmacologic Inhibition of Myostatin in a Murine Model of Osteogenesis Imperfecta., PMID:33249643
A Novel Nanobody Directed against Ovine Myostatin to Enhance Muscle Growth in Mouse., PMID:32796682
A new protein curbs the hypertrophic effect of myostatin inhibition, adding remarkable endurance to motor performance in mice., PMID:32160187
GASP-2 overexpressing mice exhibit a hypermuscular phenotype with contrasting molecular effects compared to GASP-1 transgenics., PMID:31960486
Prevalence of DLL3, CTLA-4 and MSTN Expression in Patients with Small Cell Lung Cancer., PMID:31819500
Detection of the myostatin-neutralizing antibody Domagrozumab in serum by means of Western blotting and LC-HRMS., PMID:31692253
Comparing Model Performance in Characterizing the PK/PD of the Anti-Myostatin Antibody Domagrozumab., PMID:31550073
Significant body mass increase by oral administration of a cascade of shIL21-MSTN yeast-based DNA vaccine in mice., PMID:31302418
A sensitive antibody-free 2D-LC-MS/MS assay for the quantitation of myostatin in the serum of different species., PMID:31218899
Identification of the minimum region of flatfish myostatin propeptide (Pep45-65) for myostatin inhibition and its potential to enhance muscle growth and performance in animals., PMID:30998775
Specific inhibition of myostatin activation is beneficial in mouse models of SMA therapy., PMID:30481286
Biological scaffold-mediated delivery of myostatin inhibitor promotes a regenerative immune response in an animal model of Duchenne muscular dystrophy., PMID:30139748
Sarcopenia., PMID:30098424
Brown Adipose Tissue Controls Skeletal Muscle Function via the Secretion of Myostatin., PMID:30078553
GDF11 Improves Angiogenic Function of EPCs in Diabetic Limb Ischemia., PMID:30026260
A mouse anti-myostatin antibody increases muscle mass and improves muscle strength and contractility in the mdx mouse model of Duchenne muscular dystrophy and its humanized equivalent, domagrozumab (PF-06252616), increases muscle volume in cynomolgus monkeys., PMID:29121992
Application of Quantitative Pharmacology Approaches in Bridging Pharmacokinetics and Pharmacodynamics of Domagrozumab From Adult Healthy Subjects to Pediatric Patients With Duchenne Muscular Disease., PMID:29023829
Co-Administration of Myostatin-Targeting siRNA and ActRIIB-Fc Fusion Protein Increases Masseter Muscle Mass and Fiber Size., PMID:28978871
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Domagrozumab (PF-06252616), an Antimyostatin Monoclonal Antibody, in Healthy Subjects., PMID:28881472
The Use of Platelet-Rich and Platelet-Poor Plasma to Enhance Differentiation of Skeletal Myoblasts: Implications for the Use of Autologous Blood Products for Muscle Regeneration., PMID:28027451
Irisin and Myostatin Levels in Patients with Graves' Disease., PMID:27986127
Beyond CDR-grafting: Structure-guided humanization of framework and CDR regions of an anti-myostatin antibody., PMID:27625211
Myostatin signals through miR-34a to regulate Fndc5 expression and browning of white adipocytes., PMID:27297797
Myostatin deficiency but not anti-myostatin blockade induces marked proteomic changes in mouse skeletal muscle., PMID:27214824
Combination of Weight-Bearing Training and Anti-MSTN Polyclonal Antibody Improve Bone Quality In Rats., PMID:27098383
Anti-myostatin antibody increases muscle mass and strength and improves insulin sensitivity in old mice., PMID:26858428
Myostatin antibody (LY2495655) in older weak fallers: a proof-of-concept, randomised, phase 2 trial., PMID:26516121
Circulating Growth Differentiation Factor 11/8 Levels Decline With Age., PMID:26489925
Inhibiting myostatin signaling prevents femoral trabecular bone loss and microarchitecture deterioration in diet-induced obese rats., PMID:26438721
Production of bioactive chicken (Gallus gallus) follistatin-type proteins in E. coli., PMID:26302688
Myostatin is a direct regulator of osteoclast differentiation and its inhibition reduces inflammatory joint destruction in mice., PMID:26236992
Myostatin inhibitors in sports drug testing: Detection of myostatin-neutralizing antibodies in plasma/serum by affinity purification and Western blotting., PMID:26223570
For research use only. Not for human or drug use.
