Catalog No.
RHA11501
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Applications
ELISA, IHC, WB
Recommended Dilution
| Application |
Dilution |
| ELISA |
1:10000, IHC: 1:200-1:1000, WB: 1:500-1:2000 |
Target
Dynamin family member proline-rich carboxyl-terminal domain less, DVLP, Dynamin-like protein IV, Dynamin-related protein 1, Dynamin-like protein, DLP1, Dymple, Dynamin-1-like protein, HdynIV, Dnm1p/Vps1p-like protein, DRP1, DNM1L, Dynamin-like protein 4
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
O00429
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% Sodium Azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R2T47
Note
For research use only.
Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission., PMID:21701560
Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage., PMID:22367970
Parkinson's disease-associated DJ-1 mutations impair mitochondrial dynamics and cause mitochondrial dysfunction., PMID:22428580
Dynamic changes of mitochondrial fission proteins after transient cerebral ischemia in mice., PMID:22498177
Mitochondrial dysfunction in antiphospholipid syndrome: implications in the pathogenesis of the disease and effects of coenzyme Q(10) treatment., PMID:22529290
Mitochondrial hyperfusion induced by loss of the fission protein Drp1 causes ATM-dependent G2/M arrest and aneuploidy through DNA replication stress., PMID:23015593
Declines in Drp1 and parkin expression underlie DNA damage-induced changes in mitochondrial length and neuronal death., PMID:23345212
Dynamics of nucleoid structure regulated by mitochondrial fission contributes to cristae reformation and release of cytochrome c., PMID:23821750
The mitochondrial elongation factors MIEF1 and MIEF2 exert partially distinct functions in mitochondrial dynamics., PMID:23880462
HRES-1/Rab4-mediated depletion of Drp1 impairs mitochondrial homeostasis and represents a target for treatment in SLE., PMID:23897774
Atypical mitochondrial fission upon bacterial infection., PMID:24043775
The neuroprotective effect of carnosine (β-alanyl-L-histidine) on retinal ganglion cell following ischemia-reperfusion injury., PMID:24206188
Structural and functional analysis of MiD51, a dynamin receptor required for mitochondrial fission., PMID:24515348
Relocation of p25α/tubulin polymerization promoting protein from the nucleus to the perinuclear cytoplasm in the oligodendroglia of sporadic and COQ2 mutant multiple system atrophy., PMID:25208467
Mitochondrial Dysfunction in the Liver and Antiphospholipid Antibody Production Precede Disease Onset and Respond to Rapamycin in Lupus-Prone Mice., PMID:27332042
Ang-(1-7) inhibited mitochondrial fission in high-glucose-induced podocytes by upregulation of miR-30a and downregulation of Drp1 and p53., PMID:27789249
Advanced glycation end products influence mitochondrial fusion-fission dynamics through RAGE in human aortic endothelial cells., PMID:31966653
ALS-associated mutation SOD1G93A leads to abnormal mitochondrial dynamics in osteocytes., PMID:29030231
Overcoming Resistance to Cetuximab with Honokiol, A Small-Molecule Polyphenol., PMID:29054984
Evolution of cytokinesis-related protein localization during the emergence of multicellularity in volvocine green algae., PMID:29212441
BI1 is associated with microvascular protection in cardiac ischemia reperfusion injury via repressing Syk-Nox2-Drp1-mitochondrial fission pathways., PMID:29623489
Novel Therapeutic Targets in Cutaneous Squamous Cell Carcinoma., PMID:29629337
Effect of Qiangji Jianli decoction on mitochondrial respiratory chain activity and expression of mitochondrial fusion and fission proteins in myasthenia gravis rats., PMID:29872094
Calcineurin/P38MAPK/HSP27-dependent pathways are involved in the attenuation of postischemic mitochondrial injury afforded by sodium bicarbonate co-transporter (NBCe1) inhibition., PMID:30615862
Expression of mitochondrial dynamics markers during melanoma progression: Comparative study of head and neck cutaneous and mucosal melanomas., PMID:30916813
Emerging views of mitophagy in immunity and autoimmune diseases., PMID:30951392
Hyperbaric oxygen promotes mitophagy by activating CaMKKβ/AMPK signal pathway in rats of neuropathic pain., PMID:31382832
Two distinct actin filament populations have effects on mitochondria, with differences in stimuli and assembly factors., PMID:31413070
Apolipoprotein E negatively regulates murine allergic airway inflammation via suppressing the activation of NLRP3 inflammasome and oxidative stress., PMID:32062073
Quantifying Drp1-Mediated Mitochondrial Fission by Immunostaining in Fixed Cells., PMID:32529373
Imaging Dynamin-Related Protein 1 (Drp1)-Mediated Mitochondrial Fission in Living Cells., PMID:32529374
Ganglioside GD3 regulates dendritic growth in newborn neurons in adult mouse hippocampus via modulation of mitochondrial dynamics., PMID:32743804
Mitochondrial Dynamics and VMP1-Related Selective Mitophagy in Experimental Acute Pancreatitis., PMID:33816487
MYO1F Regulates IgE and MRGPRX2-Dependent Mast Cell Exocytosis., PMID:33941653
Activation of CD137 signaling promotes macrophage apoptosis dependent on p38 MAPK pathway-mediated mitochondrial fission., PMID:33971320
Necroptosis Inhibition by Hydrogen Sulfide Alleviated Hypoxia-Induced Cardiac Fibroblasts Proliferation via Sirtuin 3., PMID:34769322
Transcriptomic and ultrastructural evidence indicate that anti-HMGB1 antibodies rescue organic dust-induced mitochondrial dysfunction., PMID:35244775
Analysis of hemisphere-dependent effects of unilateral intrastriatal injection of α-synuclein pre-formed fibrils on mitochondrial protein levels, dynamics, and function., PMID:35606853
Panax notoginseng saponin R1 attenuates allergic rhinitis through AMPK/Drp1 mediated mitochondrial fission., PMID:35623408
Dynamin-like Protein 1 (DNML1) as a Molecular Target for Antibody-Based Immunotherapy to Treat Glaucoma., PMID:36362420
Photobiomodulation therapy with light-emitting diode in stimulating adipose tissue mitochondria., PMID:37851070
NME3 is a gatekeeper for DRP1-dependent mitophagy in hypoxia., PMID:38480688
APOE and Alzheimer's disease: Pathologic clues from transgenic Drosophila melanogaster., PMID:38537387
Nanobodies as novel tools to monitor the mitochondrial fission factor Drp1., PMID:38816213
MSCs-derived HGF alleviates senescence by inhibiting unopposed mitochondrial fusion-based elongation in post-acute kidney injury., PMID:39563422
MEHP induced mitochondrial damage by promoting ROS production in CIK cells, leading to apoptosis, autophagy, cell cycle arrest., PMID:39586385
[Mechanism of the pretreatment with electroacupuncture of "biaoben acupoint combination" for regulating cardiomyocyte mitochondrial fission in the rats of myocardial ischemia-reperfusion injury]., PMID:40097217
Enhancing anti-CD3 mAb-mediated diabetes remission in autoimmune diabetes through regulation of dynamin-related protein 1(Drp1)-mediated mitochondrial dynamics in exhausted CD8+T-cell subpopulations., PMID:40165248
Yellow fever virus infection alters mitochondrial network dynamics and trigger IFN-I response via TLR2 pathway., PMID:40300356
Ginsenoside Compound K Mitigates Mitochondrial Fission Through Bile Acid Receptors/YAP Signaling to Counteract Podocyte Injury in Lupus Nephritis., PMID:40528637
For research use only. Not for human or drug use.
