Catalog No.
RHA02604
Species reactivity
Human, Mouse, Rat
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Applications
IHC
Recommended Dilution
| Application |
Dilution |
| IHC |
1:50-1:100 |
Target
SGK, Serine/threonine-protein kinase Sgk1, Serum/glucocorticoid-regulated kinase 1, SGK1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
O00141
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.5% BSA, 0.05% Sodium Azide and 50% Glycerol.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
R2T19
Note
For research use only.
Cell surface expression of the ROMK (Kir 1.1) channel is regulated by the aldosterone-induced kinase, SGK-1, and protein kinase A., PMID:12684516
Distribution and regulation of expression of serum- and glucocorticoid-induced kinase-1 in the rat kidney., PMID:12816971
WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate., PMID:14611643
Expression of ENaC and serum- and glucocorticoid-induced kinase 1 in the rat intestinal epithelium., PMID:14630642
Retinal colocalization and in vitro interaction of the glutamate transporter EAAT3 and the serum- and glucocorticoid-inducible kinase SGK1 [correction]., PMID:15111600
A naturally occurring human Nedd4-2 variant displays impaired ENaC regulation in Xenopus laevis oocytes., PMID:15140763
Identification of filamin C as a new physiological substrate of PKBalpha using KESTREL., PMID:15461588
Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3., PMID:15461589
Nedd4-2 isoforms differentially associate with ENaC and regulate its activity., PMID:15814530
Aldosterone-induced serum and glucocorticoid-induced kinase 1 expression is accompanied by Nedd4-2 phosphorylation and increased Na+ transport in cortical collecting duct cells., PMID:15958725
Long-term effects of vasopressin on the subcellular localization of ENaC in the renal collecting system., PMID:16528252
DOCA-induced phosphorylation of glycogen synthase kinase 3beta., PMID:16543730
14-3-3 isoforms are induced by aldosterone and participate in its regulation of epithelial sodium channels., PMID:16613846
Glucocorticoid receptor activation signals through forkhead transcription factor 3a in breast cancer cells., PMID:16690749
Aldosterone-stimulated SGK1 activity mediates profibrotic signaling in the mesangium., PMID:18184857
Regulation Fe65 localization to the nucleus by SGK1 phosphorylation of its Ser566 residue., PMID:18304449
Corticotropin-releasing hormone stimulates SGK-1 kinase expression in cultured hippocampal neurons via CRH-R1., PMID:18713960
Expression patterns of Nedd4 isoforms and SGK1 in the rat cochlea., PMID:19051070
APC sensitive gastric acid secretion., PMID:19255508
Stimulation of electrogenic intestinal dipeptide transport by the glucocorticoid dexamethasone., PMID:19672619
Pioglitazone induced gastric acid secretion., PMID:19710534
Oxygen regulation of the epithelial Na channel in the collecting duct., PMID:21123494
Dexamethasone increases the phosphorylation of nephrin in cultured podocytes., PMID:21695412
The serum- and glucocorticoid-inducible kinase 1 (SGK1) influences platelet calcium signaling and function by regulation of Orai1 expression in megakaryocytes., PMID:22031864
Effect of Poria cocos on hypertonic stress-induced water channel expression and apoptosis in renal collecting duct cells., PMID:22414475
Development of monoclonal antibodies specific to ribosomal protein S6 kinase 2., PMID:22894784
The serum- and glucocorticoid-induced protein kinase-1 (Sgk-1) mitochondria connection: identification of the IF-1 inhibitor of the F(1)F(0)-ATPase as a mitochondria-specific binding target and the stress-induced mitochondrial localization of endogenous Sgk-1., PMID:23402912
PIKfyve sensitivity of hERG channels., PMID:23735862
Sgk1-dependent stimulation of cardiac Na+/H+ exchanger Nhe1 by dexamethasone., PMID:23860121
[Preliminary study of apoptotic inhibition and its molecular mechanism of dexamethasone on cisplatin-induced human lung adenocarcinoma cell line SPCA/I]., PMID:24490498
Upregulation of store operated Ca channel Orai1, stimulation of Ca(2+) entry and triggering of cell membrane scrambling in platelets by mineralocorticoid DOCA., PMID:24525794
Functionally distinct PI 3-kinase pathways regulate myelination in the peripheral nervous system., PMID:24687281
Expression of ENaC, SGK1 and Nedd4 isoforms in the cochlea of guinea pig., PMID:25007182
Endothelial Na+/H+ exchanger NHE1 participates in redox-sensitive leukocyte recruitment triggered by methylglyoxal., PMID:25270604
Genistein inhibits human colorectal cancer growth and suppresses miR-95, Akt and SGK1., PMID:25871428
Sodium chloride inhibits the suppressive function of FOXP3+ regulatory T cells., PMID:26524592
Renal tubular SGK1 deficiency causes impaired K+ excretion via loss of regulation of NEDD4-2/WNK1 and ENaC., PMID:27009335
Convergent Signaling Pathways Regulate Parathyroid Hormone and Fibroblast Growth Factor-23 Action on NPT2A-mediated Phosphate Transport., PMID:27432882
SGK1 affects RAN/RANBP1/RANGAP1 via SP1 to play a critical role in pre-miRNA nuclear export: a new route of epigenomic regulation., PMID:28358001
SGK1 inhibition induces autophagy-dependent apoptosis via the mTOR-Foxo3a pathway., PMID:29017179
Sodium chloride inhibits IFN-γ, but not IL-4, production by invariant NKT cells., PMID:29345057
The phosphorylation site T613 in the β-subunit of rat epithelial Na+ channel (ENaC) modulates channel inhibition by Nedd4-2., PMID:29397423
Could Sodium Chloride be an Environmental Trigger for Immune-Mediated Diseases? An Overview of the Experimental and Clinical Evidence., PMID:29740348
Targeting SGK1 enhances the efficacy of radiotherapy in locally advanced rectal cancer., PMID:32036218
Glucocorticoids and serum- and glucocorticoid-inducible kinase 1 are potent regulators of CFTR in the native intestine: implications for stress-induced diarrhea., PMID:32567324
The relationship between the mTOR signaling pathway and ovarian aging in peak-phase and late-phase laying hens., PMID:33357698
Potassium Activates mTORC2-dependent SGK1 Phosphorylation to Stimulate Epithelial Sodium Channel: Role in Rapid Renal Responses to Dietary Potassium., PMID:36890646
Phosphatases maintain low catalytic activity of SGK1: DNA damage resets the balance in favor of phosphorylation., PMID:37343701
Transcriptome Analysis Reveals the Induction of Apoptosis-Related Genes by a Monoclonal Antibody against a New Epitope of CD99 on T-Acute Lymphoblastic Leukemia., PMID:38804310
Effect of IL-9 neutralising antibody on pyroptosis via SGK1/NF-κB/NLRP3/GSDMD in allergic rhinitis mice., PMID:38917753
For research use only. Not for human or drug use.
