Catalog No.
EHD11501
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Met1-Gly320
Predicted molecular weight
37.87 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P15509
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CD116, CSF2R, GMR-alpha, CSF2RA, Granulocyte-macrophage colony-stimulating factor receptor subunit alpha, CSF2RY, GMCSFR-alpha, GM-CSF-R-alpha, CDw116
Restitutio ad integrum: Rescuing the Alveolar Macrophage Function with HSCT in Pulmonary Alveolar Proteinosis Due to CSF2Rα Deficiency., PMID:39621143
CBL mutations in chronic myelomonocytic leukemia often occur in the RING domain with multiple subclones per patient: Implications for targeting., PMID:39298477
Macrophage colony-stimulating factor receptor/CD115+ non-classical monocytes are expanded in systemic lupus erythematosus and associated with lupus nephritis., PMID:39171822
[A first-in-human clinical trial of piggyBac transposon-mediated GMR CAR-T cells against CD116-positive acute myeloid leukemia and juvenile myelomonocytic leukemia]., PMID:35922947
A murine model of hereditary pulmonary alveolar proteinosis caused by homozygous Csf2ra gene disruption., PMID:35043685
CD116+ fetal precursors migrate to the perinatal lung and give rise to human alveolar macrophages., PMID:35019940
A novel immune-related prognostic index for predicting breast cancer overall survival., PMID:33146847
In-depth characterization of monocyte subsets during the course of healthy pregnancy., PMID:32531656
miR-532-3p-CSF2RA Axis as a Key Regulator of Vulnerable Atherosclerotic Plaque Formation., PMID:32473103
Expression of granulocyte macrophage-colony stimulating factor and its receptor in the synovium of osteoarthritis patients is negatively correlated with pain., PMID:32365364
A Novel Molecular Pathway of Plaque Vulnerability Reveals a Cholesterol-Independent Effect of Statins and Supports Inflammation as a Therapeutic Target., PMID:32315602
The Relationship Between Cytokine Production, CSF2RA, and IL1R2 Expression in Mammary Adenocarcinoma, Tumor Histopathological Parameters, and Lymph Node Metastasis., PMID:31635541
Modified eosinophil adhesion in pulmonary alveolar proteinosis caused by CSF2RA deletion., PMID:31303308
Quantitative Lipidomics in Pulmonary Alveolar Proteinosis., PMID:31002528
A Novel Endogenous Damage Signal, CSF-2, Activates Multiple Beneficial Functions of Adipose Tissue-Derived Mesenchymal Stem Cells., PMID:30962162
Characterization of human peritoneal monocyte/macrophage subsets in homeostasis: Phenotype, GATA6, phagocytic/oxidative activities and cytokines expression., PMID:30143680
Genetic and Transcriptomic Variation Linked to Neutrophil Granulocyte-Macrophage Colony-Stimulating Factor Signaling in Pediatric Crohn's Disease., PMID:30124884
TALEN-mediated functional correction of human iPSC-derived macrophages in context of hereditary pulmonary alveolar proteinosis., PMID:29123113
Function and Safety of Lentivirus-Mediated Gene Transfer for CSF2RA-Deficiency., PMID:28854814
A newly identified novel variant in the CSF2RA gene in a child with pulmonary alveolar proteinosis: a case report., PMID:28464852
Whole-Genome Sequencing of a Family with Hereditary Pulmonary Alveolar Proteinosis Identifies a Rare Structural Variant Involving CSF2RA/CRLF2/IL3RA Gene Disruption., PMID:28233860
Elderly-onset hereditary pulmonary alveolar proteinosis and its cytokine profile., PMID:28212655
Phenotypic expression of HbO Indonesia in two Indian families and its interaction with sickle hemoglobin., PMID:28195097
[Immunophenotypic Analysis of Acute Promyelocytic Leukemia]., PMID:27150985
Anti-proliferative effects of T cells expressing a ligand-based chimeric antigen receptor against CD116 on CD34(+) cells of juvenile myelomonocytic leukemia., PMID:26983639
Immortalized MH-S cells lack defining features of primary alveolar macrophages and do not support mouse pneumovirus replication., PMID:26916143
Identification of novel kinase fusion transcripts in paediatric B cell precursor acute lymphoblastic leukaemia with IKZF1 deletion., PMID:26404892
Differential antigen expression and aberrant signaling via PI3/AKT, MAP/ERK, JAK/STAT, and Wnt/β catenin pathways in Lin-/CD38-/CD34+ cells in acute myeloid leukemia., PMID:26010294
Changes in Functional Activity of JEG-3 Trophoblast Cell Line in the Presence of Factors Secreted by Placenta., PMID:26003221
Engineering superactive granulocyte macrophage colony-stimulating factor transferrin fusion proteins as orally-delivered candidate agents for treating neurodegenerative disease., PMID:25737095
Characterization of CSF2RA mutation related juvenile pulmonary alveolar proteinosis., PMID:25425184
In vitro expansion of CD34(+)CD38(-) cells under stimulation with hematopoietic growth factors on AGM-S3 cells in juvenile myelomonocytic leukemia., PMID:25102944
An overall characterization of pediatric acute lymphoblastic leukemia with CRLF2 overexpression., PMID:24935070
STAT3-activated GM-CSFRα translocates to the nucleus and protects CLL cells from apoptosis., PMID:24836891
Modeling pulmonary alveolar proteinosis with induced pluripotent stem cells., PMID:24428646
Use of induced pluripotent stem cells to recapitulate pulmonary alveolar proteinosis pathogenesis., PMID:24279752
Gene correction of human induced pluripotent stem cells repairs the cellular phenotype in pulmonary alveolar proteinosis., PMID:24279725
GM-CSF as a therapeutic target in inflammatory diseases., PMID:23933508
De novo complex X chromosome rearrangement unmasking maternally inherited CSF2RA deletion in a girl with pulmonary alveolar proteinosis., PMID:23918747
Peripheral monocyte functions and activation in patients with quiescent Crohn's disease., PMID:23658649
Toll-like receptor-mediated eosinophil-basophil differentiation: autocrine signalling by granulocyte-macrophage colony-stimulating factor in cord blood haematopoietic progenitors., PMID:23347362
Hereditary pulmonary alveolar proteinosis. Could it be triggered by Mycoplasma pneumoniae pneumonia?, PMID:23206404
Defective leukocyte GM-CSF receptor (CD116) expression and function in inflammatory bowel disease., PMID:21557945
Inflammation-related signaling pathways implicating TGFβ are revealed in the expression profiling of MCF7 cell treated with fermented soybean, chungkookjang., PMID:21547849
Adult-onset hereditary pulmonary alveolar proteinosis caused by a single-base deletion in CSF2RB., PMID:21075760
Immune dysregulation in the pathogenesis of pulmonary alveolar proteinosis., PMID:20623372
Hereditary pulmonary alveolar proteinosis: pathogenesis, presentation, diagnosis, and therapy., PMID:20622029
Pulmonary alveolar proteinosis, a primary immunodeficiency of impaired GM-CSF stimulation of macrophages., PMID:19796925
Neutrophil hyperchemotaxis in Behçet's disease: a possible role for monocytes orchestrating bacterial-induced innate immune responses., PMID:19701803
Extended diagnostic criteria for plasmacytoid dendritic cell leukaemia., PMID:19388928
For research use only. Not for human or drug use.
