Catalog No.
EHD09001
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Met1-Asn343
Predicted molecular weight
38.13 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P15151
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Nectin-like protein 5, Poliovirus receptor, CD155, PVR, PVS, NECL-5
A Novel Class of Multi-substituted Diaryl Scaffold Derivatives Inhibit Glioblastoma Progression by Targeting CD155., PMID:40492418
Pan-cancer analysis identifies CD155 as a promising target for CAR-T cell therapy., PMID:40457441
Acute mountain sickness prediction: a concerto of multidimensional phenotypic data and machine learning strategies in the framework of predictive, preventive, and personalized medicine., PMID:40438497
Investigation of TIGIT, PVRIG, CD112 and CD155 expression in early and late onset preeclampsia., PMID:40425968
NECTIN4 regulates the cell surface expression of CD155 in non-small cell lung cancer cells and induces tumor resistance to PD-1 inhibitors., PMID:40392373
Prognostic and diagnostic value of PVR gene and protein levels, serum amylase, and urinary IGFBP-7 and TIMP-2 biomarkers in multiple myeloma., PMID:40369504
Overcoming NK-mediated rejection by anti-3rd-party central memory veto CD8 T cells through downregulation of DNAM-1 on alloreactive NK cells., PMID:40343795
Potential Roles of Serum Exosomal CD155 and its Impact on NK Cell Immunosuppression in Hepatocellular Carcinoma., PMID:40326845
GD2-CAR NK-92 cell activity against neuroblastoma cells is insusceptible to TIGIT knockout., PMID:40317320
T-cell immunoglobulin and ITIM domain as a target in combo anti-PD-(L)1 cancer therapy., PMID:40294684
Promising New Anti-TIGIT Agents: Stealthy Allies in Cancer Immunotherapy., PMID:40261799
CD155 blockade enhances allogeneic natural killer cell-mediated antitumor response against osteosarcoma., PMID:40234092
Bispecific antibody targeting CD155 mediates T-cell immunotherapy against human gynecological malignancies., PMID:40232354
Targeting the poliovirus receptor to activate T cells and induce myeloid-derived suppressor cells to differentiate to pro-inflammatory macrophages via the IFN-γ-p-STAT1-IRF8 axis in cancer therapy., PMID:40229462
Troxerutin suppresses the stemness of osteosarcoma via the CD155/SRC/β-catenin signaling axis., PMID:40217455
Integrating bioinformatics with experimental validation unveils immunological and prognostic significance of PVRIG in pan-cancer., PMID:40204776
Pinpointing potent hits for cancer immunotherapy targeting the TIGIT/PVR pathway using the XGBoost model, centroid-based virtual screening, and MD simulation., PMID:40194343
TIGIT/PVR axis regulates anti-tumor immunity in hematologic malignancies., PMID:40074838
PVR exposure influences the activation, adhesion, and protein expression of human CD8+ T cells, including the CD96-mediated transfer of PVR., PMID:40073261
Effects of c-Kit Receptor, AKT, and NF-κB Inhibitors on Immune Evasion in Multiple Myeloma Cells., PMID:40052893
Preclinical application of a CD155 targeting chimeric antigen receptor T cell therapy for digestive system cancers., PMID:40025231
[Expression and Clinical Significance of Co-inhibitory Molecules TIGIT/CD155 and PD-1 in Chronic Lymphocytic Leukemia]., PMID:40017186
CD155 promotes the progression of colorectal cancer by restraining CD8+ T cells via the PI3K/AKT/NF-κB pathway., PMID:39891722
CD155 promotes the advancement of hepatocellular carcinoma by suppressing the p53-mediated ferroptosis via interacting with CD96., PMID:39878917
Identification of Epinastine as CD96/PVR inhibitor for cancer immunotherapy., PMID:39871281
Co-blocking TIGIT and PVRIG Using a Novel Bispecific Antibody Enhances Antitumor Immunity., PMID:39851063
Reprogramming the melanoma and immunosuppressive myeloid cells with esomeprazole-loaded PLGA nanoparticles., PMID:39839438
Prognostic Relevance of Immunosuppressive CD155/TIGIT Signaling in Locally Advanced Rectal Cancer Patients With Neoadjuvant Chemoradiotherapy., PMID:39740825
Identification of the therapeutic potential of novel TIGIT/PVR interaction blockers based advanced computational techniques and experimental validation., PMID:39729827
The role of TIGIT-CD226-PVR axis in mediating T cell exhaustion and apoptosis in NSCLC., PMID:39725799
Exosomal PVRL4 Promotes Lung Adenocarcinoma Progression by Enhancing the Generation of Myeloid-Derived Suppressor Cell-Secreted TGF-β1., PMID:39723644
SOCS1 Inhibits IL-6-Induced CD155 Overexpression in Lung Adenocarcinoma., PMID:39596207
Targeting the immune privilege of tumor-initiating cells to enhance cancer immunotherapy., PMID:39515328
Spatial and Single-Cell Analyses Reveal Heterogeneity of DNAM-1 Receptor-Ligand Interactions That Instructs Intratumoral γδT-cell Activity., PMID:39514370
Molecular mechanisms of transmitted endoplasmic reticulum stress mediating immune escape of gastric cancer via PVR overexpression in TAMs., PMID:39486660
Clinical significance of CD155 expression in surgically resected lung squamous cell carcinoma., PMID:39441454
Iron-loaded cancer-associated fibroblasts induce immunosuppression in prostate cancer., PMID:39426954
Effect of plasma-induced oxidation on NK cell immune checkpoint ligands: A computational-experimental approach., PMID:39395241
Polymeric immunoglobulin receptor promotes Th2 immune response in the liver by increasing cholangiocytes derived IL-33: a diagnostic and therapeutic biomarker of biliary atresia., PMID:39288533
Prognostic impact of nectin-like molecule-5 (CD155) expression in non-small cell lung cancer., PMID:39267111
Relationship between TIGIT expression on T cells and the prognosis of patients with hepatocellular carcinoma., PMID:39251968
The Nectin family ligands, PVRL2 and PVR, in cancer immunology and immunotherapy., PMID:39156900
Genetic associations and parent-of-origin effects of PVRL1 in non-syndromic cleft lip with or without cleft palate across multiple ethnic populations., PMID:39139080
Identification of Poliovirus Receptor-like 3 Protein as a Prognostic Factor in Triple-Negative Breast Cancer., PMID:39120328
Aspirin Inhibits Colorectal Cancer via the TIGIT-BCL2-BAX pathway in T Cells., PMID:39113892
Glycan-shielded homodimer structure and dynamical features of the canine distemper virus hemagglutinin relevant for viral entry and efficient vaccination., PMID:39046448
Increased PVR Expression on Bone Marrow Macrophages May Promote Resistance to TIGIT Blockade in Multiple Myeloma., PMID:38990101
Blockade of the TIGIT-CD155/CD112 axis enhances functionality of NK-92 but not cytokine-induced memory-like NK cells toward CD155-expressing acute myeloid leukemia., PMID:38967649
Cancer cell plasticity defines response to immunotherapy in cutaneous squamous cell carcinoma., PMID:38914547
CD155 Expression in Early-Stage Lung Adenocarcinoma., PMID:38901626
For research use only. Not for human or drug use.
