Catalog No.
RHN82101
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IP: 1:20, WB: 1:500-1:1000
Target
Aurora- and IPL1-like midbody-associated protein 1, AIRK2, ARK2, Serine/threonine-protein kinase aurora-B, AIM-1, Aurora 1, Aurora-related kinase 2, AIM1, Aurora kinase B, Aurora/IPL1-related kinase 2, STK1, STK12, AIK2, AURKB, ARK-2, STK-1, STK5, Serine/threonine-protein kinase 12, Serine/threonine-protein kinase 5
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q96GD4
Applications
IP, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R2S26
Prognostic value of Aurora B expression in cancer patients: A meta-analysis., PMID:40444809
Development and validation of a multiple myeloma diagnostic model based on systemic lupus erythematosus-associated genes and identification of specific genes., PMID:40382732
The Aurora B-controlled PP1/RepoMan complex determines the spatial and temporal distribution of mitotic H2B S6 phosphorylation., PMID:38806145
Identification of novel tumor-associated antigens and evaluation of a panel of autoantibodies in detecting oral cancer., PMID:37641028
Investigation of the mechanisms and experimental verification of Shao yao gan cao decoction against Sphincter of Oddi Dysfunction via systems pharmacology., PMID:36654051
CDK11p58-cyclin L1β regulates abscission site assembly., PMID:31653703
Immunohistochemical Study of Mitosis-regulatory Proteins in Gastroenteropancreatic Neuroendocrine Neoplasms., PMID:29970506
Aurora B opposes PP1 function in mitosis by phosphorylating the conserved PP1-binding RVxF motif in PP1 regulatory proteins., PMID:29764992
Disruptions in asymmetric centrosome inheritance and WDR62-Aurora kinase B interactions in primary microcephaly., PMID:28272472
Analysis of HDACi-Induced Changes in Chromosomal Passenger Complex Localization., PMID:27761812
Acetylation of Aurora B by TIP60 ensures accurate chromosomal segregation., PMID:26829474
Cdk1 orders mitotic events through coordination of a chromosome-associated phosphatase switch., PMID:26674376
Inhibition of the Aurora A kinase augments the anti-tumor efficacy of oncolytic measles virotherapy., PMID:26272026
Elevated Aurora B expression contributes to chemoresistance and poor prognosis in breast cancer., PMID:25755770
Aurora B expression and histone variant H1.4S27 phosphorylation are no longer coordinated during metaphase in aneuploid colorectal carcinomas., PMID:25680570
Overcoming cetuximab resistance in HNSCC: the role of AURKB and DUSP proteins., PMID:25192874
Molecular profiling of childhood cancer: Biomarkers and novel therapies., PMID:26675306
BuGZ is required for Bub3 stability, Bub1 kinetochore function, and chromosome alignment., PMID:24462187
Aurora B but not rho/MLCK signaling is required for localization of diphosphorylated myosin II regulatory light chain to the midzone in cytokinesis., PMID:23951055
Chk1 and Mps1 jointly regulate correction of merotelic kinetochore attachments., PMID:23321637
Novel pyrimidine-2,4-diamine derivative suppresses the cell viability and spindle assembly checkpoint activity by targeting Aurora kinases., PMID:23104179
Haspin inhibitors reveal centromeric functions of Aurora B in chromosome segregation., PMID:23071152
Aurora kinase B is a potential therapeutic target in pediatric diffuse intrinsic pontine glioma., PMID:22971244
Aurora B is regulated by acetylation/deacetylation during mitosis in prostate cancer cells., PMID:22751009
MARCKS actin-binding capacity mediates actin filament assembly during mitosis in human hepatic stellate cells., PMID:22555845
Aurora kinase B/C inhibition impairs malignant glioma growth in vivo., PMID:22382783
Aurora A inhibitor (MLN8237) plus vincristine plus rituximab is synthetic lethal and a potential curative therapy in aggressive B-cell non-Hodgkin lymphoma., PMID:22374334
Aneugenic potential of the anticancer drugs melphalan and chlorambucil. The involvement of apoptosis and chromosome segregation regulating proteins., PMID:22025197
Aurora kinase inhibition overcomes cetuximab resistance in squamous cell cancer of the head and neck., PMID:21865609
Misregulation of mitotic chromosome segregation in a new type of autosomal recessive primary microcephaly., PMID:21857152
Genetic disruption of aurora B uncovers an essential role for aurora C during early mammalian development., PMID:21613325
Cdc48/p97-Ufd1-Npl4 antagonizes Aurora B during chromosome segregation in HeLa cells., PMID:21486945
Aurora kinase B activity is modulated by thyroid hormone during transcriptional activation of pituitary genes., PMID:21239609
Chromophore-assisted light inactivation of HaloTag fusion proteins labeled with eosin in living cells., PMID:21226520
PAR, a protein involved in the cell cycle, is functionally related to chromosomal passenger proteins., PMID:21225229
Comparison of gene expression profiles reveals aberrant expression of FOXO1, Aurora A/B and EZH2 in lesional psoriatic skins., PMID:21116854
The FOXM1 transcriptional factor promotes the proliferation of leukemia cells through modulation of cell cycle progression in acute myeloid leukemia., PMID:20823107
Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosis., PMID:20705812
Specific primary sequence requirements for Aurora B kinase-mediated phosphorylation and subcellular localization of TMAP during mitosis., PMID:20458174
MCAK is present at centromeres, midspindle and chiasmata and involved in silencing of the spindle assembly checkpoint in mammalian oocytes., PMID:20406800
Visualizing histone modifications in living cells: spatiotemporal dynamics of H3 phosphorylation during interphase., PMID:19995936
Trivalent dimethylarsenic compound induces histone H3 phosphorylation and abnormal localization of Aurora B kinase in HepG2 cells., PMID:19716834
GSK1070916, a potent Aurora B/C kinase inhibitor with broad antitumor activity in tissue culture cells and human tumor xenograft models., PMID:19567821
Recruitment of separase to mitotic chromosomes is regulated by Aurora B., PMID:19342897
Expression of Aurora A (but not Aurora B) is predictive of survival in breast cancer., PMID:18628459
Involvement of elevated expression of multiple cell-cycle regulator, DTL/RAMP (denticleless/RA-regulated nuclear matrix associated protein), in the growth of breast cancer cells., PMID:18542055
Aurora B kinase and protein phosphatase 1 have opposing roles in modulating kinetochore assembly., PMID:18426974
ZM 447439 inhibition of aurora kinase induces Hep2 cancer cell apoptosis in three-dimensional culture., PMID:18418083
Identification of a novel mitotic phosphorylation motif associated with protein localization to the mitotic apparatus., PMID:17971412
Phosphorylation by aurora-B negatively regulates survivin function during mitosis., PMID:17457057
For research use only. Not for human or drug use.
