Catalog No.
EHD06901
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Met1-Asp239
Predicted molecular weight
28.32 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P14784
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
IL-2R subunit beta, Interleukin-15 receptor subunit beta, IL2RB, IL-2 receptor subunit beta, CD122, High affinity IL-2 receptor subunit beta, p75, Interleukin-2 receptor subunit beta, IL-2RB, p70-75, IL15RB
Associations among IL-6 Signaling Molecules in Treg Populations in Patients with Relapsing-Remitting Multiple Sclerosis., PMID:40464469
Oxaliplatin, ATR inhibitor and anti-PD-1 antibody combination therapy controls colon carcinoma growth, induces local and systemic changes in the immune compartment, and protects against tumor rechallenge in mice., PMID:40139833
Selective activation of interleukin-2/interleukin-15 receptor signaling in tumor microenvironment using paired bispecific antibodies., PMID:40132909
Lineage Tracking Dissects the Fate of Neonatal iNKT Cells Later in Life., PMID:39957432
The High-Affinity IL-2 Receptor Affects White Matter Damage after Cerebral Ischemia by Regulating CD8 + T Lymphocyte Differentiation., PMID:39821696
ECM29/proteasome-mediated self-antigen generation by CNS-resident neuroglia promotes regulatory T cell activation., PMID:39786996
Characterization of anti-asialo-GM1 monoclonal antibody., PMID:39693935
IL-2/anti-IL-2 antibody complexes augment immune responses to therapeutic cancer vaccines., PMID:39556726
Human serum albumin promotes interactions between HSA-IL-2 fusion protein and CD122 for enhancing immunotherapy., PMID:39522264
Metabolic programs drive function of therapeutic NK cells in hypoxic tumor environments., PMID:39475618
Rapid identification of primary atopic disorders (PAD) by a clinical landmark-guided, upfront use of genomic sequencing., PMID:39381601
PD-1+ and TIM-3+ T cells widely express common γ-chain cytokine receptors in multiple myeloma patients, and IL-2, IL-7, IL-15 stimulation up-regulates PD-1 and TIM-3 on T cells., PMID:39308517
Astragalus polysaccharide enhances antitumoral effects of chimeric antigen receptor- engineered (CAR) T cells by increasing CD122+CXCR3+PD-1- memory T cells., PMID:39243425
IL-18 primes T cells with an antigen-inexperienced memory phenotype for proliferation and differentiation into effector cells through Notch signaling., PMID:39213165
CD122 is an activation marker ensuring proper proliferation of T cells in teleost., PMID:39153581
Methazolamide Can Treat Atherosclerosis by Increasing Immunosuppressive Cells and Decreasing Expressions of Genes Related to Proinflammation, Calcification, and Tissue Remodeling., PMID:39081633
Role of STAT3-FOXO3 Signaling in the Modulation of Neuroplasticity by PD-L1-HGF-Decorated Mesenchymal Stem Cell-Derived Exosomes in a Murine Stroke Model., PMID:39049677
The TAK1/JNK axis participates in adaptive immunity by promoting lymphocyte activation in Nile tilapia., PMID:38969154
Human placental mesenchymal stromal cells promote the formation of CD8+CD122+PD-1+Tregs via CD73/Foxo1 to alleviate liver injury in graft-versus-host disease mice., PMID:38968861
Targeting a disintegrin and metalloprotease (ADAM) 17-CD122 axis enhances CD8+ T cell effector differentiation and anti-tumor immunity., PMID:38918390
Eomesodermin spatiotemporally orchestrates the early and late stages of NK cell development by targeting KLF2 and T-bet, respectively., PMID:38740922
IL-15/IL-15Rα-Fc-Fusion Protein XmAb24306 Potentiates Activity of CD3 Bispecific Antibodies through Enhancing T-Cell Expansion., PMID:38739434
PGE2 inhibits TIL expansion by disrupting IL-2 signalling and mitochondrial function., PMID:38658764
Zhen-Wu-Tang ameliorates lupus nephritis by diminishing renal tissue-resident memory CD8+ T cells via suppressing IL-15/STAT3 pathway., PMID:38643544
CSF1R blockade slows progression of cerebral hemorrhage by reducing microglial proliferation and increasing infiltration of CD8 + CD122+ T cells into the brain., PMID:38636374
A miRNA-7704/IL2RB/AKT feedback loop regulates tumorigenesis and chemoresistance in ovarian cancer., PMID:38565343
Dual Activity of Type III PI3K Kinase Vps34 is Critical for NK Cell Development and Senescence., PMID:38544346
Efbalropendekin Alfa enhances human natural killer cell cytotoxicity against tumor cell lines in vitro., PMID:38515757
rhIL-7-hyFc and hIL-2/TCB2c combination promotes an immune-stimulatory tumor microenvironment that improves antitumor efficacy of checkpoint inhibitors., PMID:38471713
Full T-cell activation and function in teleosts require collaboration of first and co-stimulatory signals., PMID:38114429
Novel Programmed Death Ligand 1-AKT-engineered Mesenchymal Stem Cells Promote Neuroplasticity to Target Stroke Therapy., PMID:38030932
Conditional deletion of CD25 in the corneal epithelium reveals sex differences in barrier disruption., PMID:37516317
IKK2/NFkB signaling controls lung resident CD8+ T cell memory during influenza infection., PMID:37468506
Combination of cancer vaccine with CD122-biased IL-2/anti-IL-2 Ab complex shapes the stem-like effector NK and CD8+ T cells against tumor., PMID:37400134
AKT inhibition interferes with the expression of immune checkpoint proteins and increases NK-induced killing of HL60-AML cells., PMID:37341216
IL2RB affects Th1/Th2 and Th17 responses of peripheral blood mononuclear cells from septic patients., PMID:37169553
Transcription factor TOX maintains the expression of Mst1 in controlling the early mouse NK cell development., PMID:37153735
Expansion of circulating stem-like CD8+ T cells by adding CD122-directed IL-2 complexes to radiation and anti-PD1 therapies in mice., PMID:37045833
Lack of Herpes Virus Entry Mediator Signals in Thymocytes Impairs Conventional CD8 T Cell Selection and Promotes Memory-like CD8 T Cell Development., PMID:37000475
Blockade of CD122 on memory T cells in the skin suppresses sclerodermatous graft-versus-host disease., PMID:36966029
Immune Phenotypic Characterization of a TRAIL-Knockout Mouse., PMID:36900266
Anti-CD122 antibody restores specific CD8+ T cell response in nonalcoholic steatohepatitis and prevents hepatocellular carcinoma growth., PMID:36891258
Implication of 99mTc-sum IL-2 SPECT/CT in immunotherapy by imaging of tumor-infiltrating T cells., PMID:36858461
Circulating CD4+ Treg, CD8+ Treg, and CD3+ γδ T Cell Subpopulations in Ovarian Cancer., PMID:36837407
Associations between KIR/KIR-ligand genotypes and clinical outcome for patients with advanced solid tumors receiving BEMPEG plus nivolumab combination therapy in the PIVOT-02 trial., PMID:36823323
Deregulated phenotype of autoreactive Th17 and Treg clone cells in pemphigus vulgaris after in-vitro treatment with desmoglein antigen (Dsg-3)., PMID:36689824
IL-15 induced bystander activation of CD8+ T cells may mediate endothelium injury through NKG2D in Hantaan virus infection., PMID:36590594
Inefficient Recovery of Repeatedly Stimulated Memory CD8 T Cells after Polymicrobial Sepsis Induction Leads to Changes in Memory CD8 T Cell Pool Composition., PMID:36480268
PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program., PMID:36171288
In vitro-induced Foxp3+ CD8+ regulatory T cells suppress allergic IgE response in the gut., PMID:36000308
For research use only. Not for human or drug use.
