Catalog No.
YHD05401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Pro531
Predicted molecular weight
60.25 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P14618
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PK2, Opa-interacting protein 3, THBP1, Tumor M2-PK, PKM, Pyruvate kinase muscle isozyme, Thyroid hormone-binding protein 1, PK3, Pyruvate kinase 2/3, p58, CTHBP, PKM2, Pyruvate kinase PKM, OIP-3, Cytosolic thyroid hormone-binding protein, OIP3
Contrasting Becker and Duchenne muscular dystrophy serum biomarker candidates by using data independent acquisition LC-MS/MS., PMID:40483507
Plasma proteome profiling of massive perivillous fibrin deposition (MPFD) in women with recurrent Miscarriages: Pathophysiological insights and biomarker discovery., PMID:40472641
Pyruvate Kinase PKM2: Basic and Translational Aspects in Molecular Diagnosis of Human Malignancies., PMID:40451197
M2 macrophage-derived exosome facilitates aerobic glycolysis and osteogenic differentiation of hPDLSCs by regulating TRIM26-induced PKM ubiquitination., PMID:40449810
miR-124/PTBP1/PKM axis modulates pulmonary artery endothelial metabolism in a pulmonary thromboembolism rat model., PMID:40400966
AARS2 ameliorates myocardial ischemia via fine-tuning PKM2-mediated metabolism., PMID:40371904
Proteomic profiling reveals a higher presence of glycolytic enzymes in human atherosclerotic lesions with unfavourable histological characteristics., PMID:40354194
A Fraction of Escherichia coli Bacteria Induces an Increase in the Secretion of Extracellular Vesicle Polydispersity in Macrophages: Possible Involvement of Secreted EVs in the Diagnosis of COVID-19 with Bacterial Coinfections., PMID:40332365
Elucidating the Role and Mechanism of Alpha-Enolase in Senescent Amelioration via Metabolic Reprogramming., PMID:40289552
Stibene glucoside prevents PM2.5 caused pulmonary fibrosis by Pseudo hypoxia, autophagy and NF-κB signal pathways., PMID:40262249
The role of PKM2-mediated metabolic reprogramming in the osteogenic differentiation of BMSCs under diabetic periodontitis conditions., PMID:40251642
HLA-F regulates the proliferation of trophoblast via PKM2-dependent glycolysis in the pathogenesis of preeclampsia., PMID:40251569
Oxidized LDL stimulates PKM2-mediated mtROS production and phagocytosis., PMID:40250804
SGLT2 inhibitor empagliflozin ameliorates tubulointerstitial fibrosis in DKD by downregulating renal tubular PKM2., PMID:40237854
Molecular and functional identification of a LC3C homolog in large yellow croaker (Larimichthys crocea)., PMID:40228590
Production and application of peptidyl-lys metalloendopeptidase: advances, challenges, and future perspectives., PMID:40208312
Comprehensive molecular characteristics of hepatocellular carcinoma based on multi-omics analysis., PMID:40159482
Glyceraldehyde-3-phosphate dehydrogenase/1,3-bisphosphoglycerate-NADH as key determinants in controlling human retinal endothelial cellular functions: Insights from glycolytic screening., PMID:40158853
PKM2 accelerated the progression of chronic fatigue syndrome via promoting the H4K12la/ NF-κB induced neuroinflammation and mitochondrial damage., PMID:40155479
Pyruvate Kinase M1/2 Proteoformics for Accurate Insights into Energy Metabolism Abnormity to Promote the Overall Management of Ovarian Cancer Towards Predictive, Preventive, and Personalized Medicine Approaches., PMID:40137167
PKM2 regulates osteoclastogenesis by affecting osteoclast precursor cell fusion via downregulation of OC-STAMP and DC-STAMP., PMID:40122175
SIRT3-PINK1-PKM2 axis prevents osteoarthritis via mitochondrial renewal and metabolic switch., PMID:40087281
Daidzein alleviates skin fibrosis by suppressing TGF-β1 signaling pathway via targeting PKM2., PMID:40082519
The Jieduquyuziyin prescription alleviates systemic lupus erythematosus by modulating B cell metabolic reprogramming via the AMPK/PKM2 signaling pathway., PMID:40081513
March2 Alleviates Aortic Aneurysm/Dissection by Regulating PKM2 Polymerization., PMID:40079144
Modification of RNF183 via m6A Methylation Mediates Podocyte Dysfunction in Diabetic Nephropathy by Regulating PKM2 Ubiquitination and Degradation., PMID:40072093
The glycolytic enzyme PKM2 regulates inflammatory osteoclastogenesis by modulating STAT3 phosphorylation., PMID:40057191
A comprehensive study on the impact of Ligustrum vicaryi L. fruit polysaccharide on myocardial fibrosis through animal experiments, network pharmacology and molecular docking., PMID:40051434
Exogenous BMI1 expression aggravates oral squamous cell carcinomas in tongue epithelia., PMID:40009939
Histone lactylation stimulated upregulation of PSMD14 alleviates neuron PANoptosis through deubiquitinating PKM2 to activate PINK1-mediated mitophagy after traumatic brain injury., PMID:40000916
PKM splice-switching ASOs induce upregulation of dual-specificity phosphatases and dephosphorylation of ERK1/2 in hepatocellular carcinoma., PMID:39993527
GMRSP encoded by lncRNA H19 regulates metabolic reprogramming and alleviates aortic dissection., PMID:39966416
Comparative proteomics and phosphoproteomics analysis reveals differential sperm motility in Mediterranean buffalo semen., PMID:39961484
Macrophage polarization-mediated PKM2/mTORC1/YME1L signaling pathway activation in fibrosis associated with Cardiorenal syndrome., PMID:39961408
Aerobic exercise acts differentially on proteins from glucose and glycogen pathways in the SOL and PL muscles of offspring rats submitted to a low-protein maternal diet., PMID:39954356
Licochalcone A prevents cognitive decline in a lipopolysaccharide-induced neuroinflammation mice model., PMID:39930360
Partial replacement of soybean meal with mixed plant proteins yields comparable growth and carcass quality in growing-finishing pigs., PMID:39911690
Nitidine chloride inhibits the progression of hepatocellular carcinoma by suppressing IGF2BP3 and modulates metabolic pathways in an m6A-dependent manner., PMID:39910429
TEPP-46 inhibits glycolysis to promote M2 polarization of microglia after ischemic stroke., PMID:39904037
Amygdala stimulation transforms short-term memory into remote memory by persistent activation of atypical protein kinase C in the anterior cingulate cortex., PMID:39900220
Proteomics Reveals the Response Mechanism of Embryonic Bovine Lung Cells to Mycoplasma bovis Infection., PMID:39859536
In vitro bisphenol A impairs testicular energy metabolism and spermatogenesis through nuclear estrogen receptors activation in zebrafish., PMID:39855486
Integrative Bioinformatics and Experimental Validation Reveal the Mechanistic Action of Patchouli Alcohol in Prostate Cancer Treatment., PMID:39844397
PKM2-mediated collagen XVII expression is critical for wound repair., PMID:39841618
The PKM2 activator TEPP-46 suppresses cellular senescence in hydrogen peroxide-induced proximal tubular cells and kidney fibrosis in CD-1db/db mice., PMID:39840670
HACD2 Promotes Pancreatic Cancer Progression by Enhancing PKM2 Dissociation From PRKN in a Dehydratase-Independent Manner., PMID:39836601
Coptisine improves LPS-induced anxiety-like behaviors by regulating the Warburg effect in microglia via PKM2., PMID:39823725
The TRPV1-PKM2-SREBP1 axis maintains microglial lipid homeostasis in Alzheimer's disease., PMID:39809738
Thermodynamic control of mismatch discrimination for extensive splicing regulation of PKM pre-mRNA., PMID:39797763
Validation and the role of PDK4 relevant to ferroptosis in degenerative lumbar disc disease., PMID:39794775
For research use only. Not for human or drug use.
