Catalog No.
YHD04801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys221-Gln373
Predicted molecular weight
19.70 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P14416
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
D(2) dopamine receptor, Dopamine D2 receptor, DRD2
Directing negative emotional states through parallel genetically-distinct basolateral amygdala pathways to ventral striatum subregions., PMID:40514388
Cocaine-induced gene regulation in D1 and D2 neuronal ensembles of the nucleus accumbens., PMID:40506501
Convergent Evolution of Two Dopamine Receptor Genes: Repeated Evolution of Exon 6 Skipping in Drd2, and Repeated Deletion of Exon 6 in Drd3., PMID:40488893
Distinct molecular patterns in R6/2 HD mouse brain: Insights from spatiotemporal transcriptomics., PMID:40482637
Impaired insulin receptor function alters psychiatric behaviors without affecting circadian rhythms in a mouse model of Alzheimer's disease., PMID:40443027
Constitutive ghrelin receptor activity enables reversal of dopamine D2 receptor signaling., PMID:40441153
Subtype-specific dysregulation of biogenic amine-related genes and miRNAs in breast cancer: identification of DRD2, HRH2, and HRH4 as potential therapeutic targets in TNBC and HER2+ subtypes., PMID:40425926
Big data-driven target identification by machine learning: DRD2 as a therapeutic target for psoriasis., PMID:40414760
Distinct Transcriptomic Profiles of Cultured Anterior and Posterior Populations of Human Infant Scleral Fibroblasts: Including Dopamine Receptors., PMID:40402520
Shared genetics and causal relationship between sociability and the brain's default mode network., PMID:40400235
Changes in gene expression of D2 and D5 receptors in the thalamus and midbrain caused by a persistent painful stimulus in Parkinsonian rats., PMID:40398708
Reduction of D2 receptors on microglia leads to ZBP1-mediated PANoptosis of mPFC in Parkinson's disease depression mice., PMID:40367691
Dopamine Receptor D3 Induces Transient, mTORC1-Dependent Autophagy That Becomes Persistent, AMPK-Mediated, and Neuroprotective in Experimental Models of Huntington's Disease., PMID:40358175
TarMGDif: Target-specific Molecular Graphs Generation Based on Diffusion Model., PMID:40354197
Abundance of dopamine and its receptors in the brain and adipose tissue following diet-induced obesity or caloric restriction., PMID:40345434
Total Alkaloid Extract of Nelumbinis Plumula Promoted Sleep in PCPA-Induced Insomnia Rats by Affecting Neurotransmitters and Their Receptor Activities., PMID:40332158
A neuroimmune pathway drives bacterial infection., PMID:40315317
Identification of allosteric sites and ligand-induced modulation in the dopamine receptor through large-scale alchemical mutation scan., PMID:40303451
Cholesterol-activated stress granules reduce the membrane localization of DRD2 and promote prolactinoma dopamine agonists resistance., PMID:40281543
Unique and overlapping mechanisms of valbenazine, deutetrabenazine, and vitamin E for tardive dyskinesia., PMID:40268947
Exploration of Bioactive Compounds in Benincasa hispida Seeds: Insight Into Their Therapeutic Potential for Alzheimer's Disease Management Using Computer-Aided Drug Design Platform., PMID:40249595
Terahertz wave targeting modulates the dedocking of neurotransmitters with receptors., PMID:40242518
Aripiprazole alleviates the high prolactin levels induced by amisulpride via distinct molecular mechanisms: a network pharmacology and molecular docking study., PMID:40229786
Valproic acid promotes transcriptional activation of Drd2 by mediating histone acetylation to inhibit the mTOR-Pttg1 signaling axis and exerts anti-PitNETs activity., PMID:40220407
Ameliorative role of naringenin in MPTP- induced Parkinsonism: Insights from Drosophila melanogaster experimental model combined with computational biology., PMID:40213420
Transcriptomic analysis and experiment to verify the mechanism of Xiaoyao san in the treatment of irritable bowel syndrome with depression., PMID:40179998
Lactobacillus paracasei-derived extracellular vesicles reverse molecular and behavioral deficits in mouse models of autism spectrum disorder., PMID:40164687
PACAP induces increased excitability in D1- and D2-expressing nucleus accumbens medium spiny neurons., PMID:40147707
The dopamine receptor agonist rotigotine attenuated indomethacin-induced enteropathy in the small intestinal mucosa of mice., PMID:40128405
Dopamine-driven increase in IL-1β in myeloid cells is mediated by differential dopamine receptor expression and exacerbated by HIV., PMID:40122818
Blocking dopamine receptor 2 decreases gastrin levels in H. pylori-infected mice through increasing gastric somatostatin content., PMID:40094279
Dopamine receptor D2 (DRD2) TaqIA gene polymorphism and acute risperidone-induced changes in body weight, plasma glucose and lipid profile., PMID:40073616
Accelerating discovery of bioactive ligands with pharmacophore-informed generative models., PMID:40064886
DRD2-Mediated AMPK Ubiquitination Regulates the Occurrence of Hepatic Steatosis., PMID:40052721
Association of the DRD and OXT Genetic Polymorphisms With Schizophrenia in a Chinese Population., PMID:39993143
Striatal dopamine D2/D3 receptor regulation of human reward processing and behaviour., PMID:39984436
Cell-Type Specific Circuits in the Mammillary Body for Place and Object Recognition Memory., PMID:39928529
The Utility of Prolonged Chronic Unpredictable Stress to Study the Effects of Chronic Fluoxetine, Eicosapentaenoic Acid, and Lipopolysaccharide on Anxiety-Like Behavior and Hippocampal Transcriptomic Responses in Male Rats., PMID:39907099
Repurposing FDA-Approved Drugs Against Potential Drug Targets Involved in Brain Inflammation Contributing to Alzheimer's Disease., PMID:39897171
Associations between inflammation and striatal dopamine D2-receptor availability in aging., PMID:39885603
Estrogen-related receptor gamma is a regulator of mitochondrial, autophagy, and immediate-early gene programs in spiny projection neurons: Relevance for transcriptional changes in Huntington disease., PMID:39884587
Access to high-fat diet results in increased sensitivity to the psychostimulant effects of MDPV in mice., PMID:39869285
Disease-Associated Dopamine Receptor D2 Variants Exhibit Functional Consequences Depending on Different Heterotrimeric G-Protein Subunit Combinations., PMID:39857630
Pharmacogenetic Testing in Treatment-resistant Panic Disorder: a Preliminary Analysis., PMID:39839219
Co-Expression of Tardive Dyskinesia and Drug-Induced Parkinsonism in Rats Chronically Treated With Haloperidol., PMID:39789385
Correlation of repetitive behaviors in deer mice with striatal mRNA expression of endogenous opioids and mu, delta, kappa, and dopamine receptors: A preliminary report., PMID:39756610
Aging-related losses in dopamine D2/3 receptor availability are linked to working-memory decline across five years., PMID:39756432
Taltirelin induces TH expression by regulating TRHR and RARα in medium spiny neurons., PMID:39736794
Action Potential Firing Patterns Regulate Dopamine Release via Voltage-Sensitive Dopamine D2 Autoreceptors in Mouse Striatum In Vivo., PMID:39731325
Genetic risk for treatment resistant schizophrenia and corresponding variation in dopamine synthesis capacity and D2/3 receptor availability in healthy individuals., PMID:39730881
For research use only. Not for human or drug use.
