Catalog No.
RHN60902
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
FCM: 1:20-1:100, IF: 1:50-1:200, IHC: 1:100-1:200, IP: 1:20-1:50, WB: 1:1000-1:5000
Target
TCF-4, HMG box transcription factor 4, T-cell-specific transcription factor 4, Transcription factor 7-like 2, T-cell factor 4, hTCF-4, TCF4, TCF7L2
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q9NQB0
Applications
FCM, IF, IHC, IP, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R2P11
Clinical signs of type 1 diabetes are associated with type 2 diabetes marker transcription factor 7-like 2 polymorphism., PMID:36300877
Interaction of lncRNA MIR100HG with hnRNPA2B1 facilitates m6A-dependent stabilization of TCF7L2 mRNA and colorectal cancer progression., PMID:35279145
Novel Reclassification of Adult Diabetes Is Useful to Distinguish Stages of β-Cell Function Linked to the Risk of Vascular Complications: The DOLCE Study From Northern Ukraine., PMID:34276762
Evaluation of the upregulation and surface expression of hypoxanthine guanine phosphoribosyltransferase in acute lymphoblastic leukemia and Burkitt's B cell lymphoma., PMID:32782434
Dendritic cells' characteristics in patients with treated systemic lupus erythematosus., PMID:32730703
Hepcidin deficiency causes bone loss through interfering with the canonical Wnt/β-catenin pathway via Forkhead box O3a., PMID:32514392
The Wnt3a/β-catenin/TCF7L2 signaling axis reduces the sensitivity of HER2-positive epithelial ovarian cancer to trastuzumab., PMID:32248976
Cullin7 enhances resistance to trastuzumab therapy in Her2 positive breast cancer via degrading IRS-1 and downregulating IGFBP-3 to activate the PI3K/AKT pathway., PMID:31461670
Understanding cornea homeostasis and wound healing using a novel model of stem cell deficiency in Xenopus., PMID:31437439
Dam mutants provide improved sensitivity and spatial resolution for profiling transcription factor binding., PMID:31196130
The Influence of Type 2 Diabetes-Associated Factors on Type 1 Diabetes., PMID:31167894
Expression and clinical significance of transcription factor 4 (TCF4) in epithelial ovarian cancer., PMID:30614797
Transcription Factor 7-Like 2 (TCF7L2) Gene Polymorphism and Progression From Single to Multiple Autoantibody Positivity in Individuals at Risk for Type 1 Diabetes., PMID:30275285
Linking FOXO3, NCOA3, and TCF7L2 to Ras pathway phenotypes through a genome-wide forward genetic screen in human colorectal cancer cells., PMID:29301589
Relative contribution of type 1 and type 2 diabetes loci to the genetic etiology of adult-onset, non-insulin-requiring autoimmune diabetes., PMID:28438156
Identification of FERM domain-containing protein 5 as a novel target of β-catenin/TCF7L2 complex., PMID:28117551
Dissecting heterogeneity in paediatric Type 1 diabetes: association of TCF7L2 rs7903146 TT and low-risk human leukocyte antigen (HLA) genotypes., PMID:27027642
Overlap of genetic susceptibility to type 1 diabetes, type 2 diabetes, and latent autoimmune diabetes in adults., PMID:25189437
Type 2 diabetes susceptibility gene variants predispose to adult-onset autoimmune diabetes., PMID:24906951
Notch-dependent RBPJκ inhibits proliferation of human cytotrophoblasts and their differentiation into extravillous trophoblasts., PMID:24850908
Loss of exon 4 in a human T-cell factor-4 isoform promotes hepatic tumourigenicity., PMID:23648141
Acetylation of human TCF4 (TCF7L2) proteins attenuates inhibition by the HBP1 repressor and induces a conformational change in the TCF4::DNA complex., PMID:23613959
Postnatal isoform switch and protein localization of LEF1 and TCF7L2 transcription factors in cortical, thalamic, and mesencephalic regions of the adult mouse brain., PMID:23152144
The type 2 diabetes-associated variant in TCF7L2 is associated with latent autoimmune diabetes in adult Europeans and the gene effect is modified by obesity: a meta-analysis and an individual study., PMID:22109281
Genetic analysis of adult-onset autoimmune diabetes., PMID:21873553
Gestational diabetes mellitus is associated with TCF7L2 gene polymorphisms independent of HLA-DQB1*0602 genotypes and islet cell autoantibodies., PMID:21672010
Effects of EpCAM overexpression on human breast cancer cell lines., PMID:21281469
Association of TCF7L2 gene variants with low GAD autoantibody titre in LADA subjects (NIRAD Study 5)., PMID:20546291
TCF-3, 4 protein expression correlates with beta-catenin expression in MSS and MSI-H colorectal cancer from HNPCC patients but not in sporadic colorectal cancers., PMID:20532534
Inhibition of endothelial cell activation by bHLH protein E2-2 and its impairment of angiogenesis., PMID:20231428
Transcriptional regulation of SM22alpha by Wnt3a: convergence with TGFbeta(1)/Smad signaling at a novel regulatory element., PMID:19344627
Single nucleotide transcription factor 7-like 2 (TCF7L2) gene polymorphisms in antiislet autoantibody-negative patients at onset of diabetes., PMID:19050058
Common variants in the TCF7L2 gene help to differentiate autoimmune from non-autoimmune diabetes in young (15-34 years) but not in middle-aged (40-59 years) diabetic patients., PMID:18839133
Variation in the CDKAL1 gene is associated with the titer of antibodies to GAD., PMID:18753662
Prediction of the immunogenic potential of frameshift-mutated antigens in microsatellite instable cancer., PMID:18506693
Regulation of Wnt signaling by the nuclear pore complex., PMID:18439914
Human homolog of NOTUM, overexpressed in hepatocellular carcinoma, is regulated transcriptionally by beta-catenin/TCF., PMID:18429952
Non-obese patients with type 2 diabetes and prediabetic subjects: distinct phenotypes requiring special diabetes treatment and (or) prevention?, PMID:18059616
Coiled-coil domain containing 85B suppresses the beta-catenin activity in a p53-dependent manner., PMID:17873903
Overexpression of axin downregulates TCF-4 and inhibits the development of lung cancer., PMID:17768662
Induction of p16INK4A mediated by beta-catenin in a TCF4-independent manner: implications for alterations in p16INK4A and pRb expression during trans-differentiation of endometrial carcinoma cells., PMID:16858682
Regulation of human nitric oxide synthase 2 expression by Wnt beta-catenin signaling., PMID:16849547
Nucleo-cytoplasmic distribution of beta-catenin is regulated by retention., PMID:16554443
Loss of beta 1 integrin function results in upregulation of connexin expression in embryonic stem cell-derived cardiomyocytes., PMID:15744665
T-cell factor-4-dependent up-regulation of fibronectin is involved in fibroblast growth factor-2-induced tube formation by endothelial cells., PMID:15578569
Overlapping expression of early B-cell factor and basic helix-loop-helix proteins as a mechanism to dictate B-lineage-specific activity of the lambda5 promoter., PMID:10779354
Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway., PMID:10027409
Restricted high level expression of Tcf-4 protein in intestinal and mammary gland epithelium., PMID:9916915
A splice variant of E2-2 basic helix-loop-helix protein represses the brain-specific fibroblast growth factor 1 promoter through the binding to an imperfect E-box., PMID:9668116
Induction of basic helix-loop-helix protein-containing complexes during erythroid differentiation., PMID:9572395
For research use only. Not for human or drug use.
