Catalog No.
YHD01201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala379-Val630
Predicted molecular weight
30.61 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P13797
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PLS3, T-plastin, Plastin-3
Human plastins are novel cytoskeletal pH sensors with a reduced F-actin bundling capacity at basic pH., PMID:40196613
Allicin alleviates traumatic brain injury-induced neuroinflammation by enhancing PKC-δ-mediated mitophagy., PMID:39986225
A Plasma Proteomics-Based Model for Identifying the Risk of Postpartum Depression Using Machine Learning., PMID:39772732
Cytoskeleton dysfunction of motor neuron in spinal muscular atrophy., PMID:39666039
Bone microarchitecture and strength in men and women with PLS3 gene variants assessed with HR-pQCT., PMID:39658012
Early-Onset Osteoporosis: Molecular Analysis in Large Cohort and Focus on the PLS3 Gene., PMID:39316135
Association among biomarkers, phenotypes, and motor milestones in Chinese patients with 5q spinal muscular atrophy types 1-3., PMID:39286802
Functional Insights in PLS3-Mediated Osteogenic Regulation., PMID:39273077
Genotype and Phenotype Correlation of Patients with Osteogenesis Imperfecta., PMID:39025364
Modeling Spinal Muscular Atrophy in Zebrafish: Current Advances and Future Perspectives., PMID:38396640
The SMA Modifier Plastin 3 Targets Cell Membrane-Associated Proteins in Motoneurons., PMID:38249130
Identification of M2 Macrophage-Related Key Genes in Advanced Atherosclerotic Plaques by Network-Based Analysis., PMID:38194604
The actin-bundling protein, PLS3, is part of the mechanoresponsive machinery that regulates osteoblast mineralization., PMID:38089885
PLS3 missense variants affecting the actin-binding domains cause X-linked congenital diaphragmatic hernia and body-wall defects., PMID:37751738
Bone fragility and osteoporosis in children and young adults., PMID:37668887
The intricate mechanism of PLS3 in bone homeostasis and disease., PMID:37484945
PLS3 promotes papillary thyroid carcinoma progression by activating the Notch signaling pathway., PMID:37347555
Medical Care Use Among Patients with Monogenic Osteoporosis Due to Rare Variants in LRP5, PLS3, or WNT1., PMID:37277619
Synovial Fluid Proteomics From Serial Aspirations of ACL-Injured Knees Identifies Candidate Biomarkers., PMID:37191559
Impaired bone strength and bone microstructure in a novel early-onset osteoporotic rat model with a clinically relevant PLS3 mutation., PMID:37083757
Prevalence of Monogenic Bone Disorders in a Dutch Cohort of Atypical Femur Fracture Patients., PMID:37076969
Epigenetic regulation of plastin 3 expression by the macrosatellite DXZ4 and the transcriptional regulator CHD4., PMID:36812914
Plastin 3 rescues cell surface translocation and activation of TrkB in spinal muscular atrophy., PMID:36607273
Trio-based exome sequencing broaden the genetic spectrum in keratoconus., PMID:36502923
Role of LONP2 in head and neck squamous cell carcinoma., PMID:36347334
Lipocalin-2 is associated with FGF23 in WNT1 and PLS3 osteoporosis., PMID:36157448
Early-Onset Osteoporosis: Rare Monogenic Forms Elucidate the Complexity of Disease Pathogenesis Beyond Type I Collagen., PMID:35949115
Identification of hub genes and regulatory networks in histologically unstable carotid atherosclerotic plaque by bioinformatics analysis., PMID:35773742
Label-free Quantitative Proteomic Analysis of Ascorbic Acid-induced Differentially Expressed Osteoblast-related Proteins in Dental Pulp Stem Cells from Deciduous and Permanent Teeth., PMID:35762553
Identification of a novel splicing mutation and genotype-phenotype correlations in rare PLS3-related childhood-onset osteoporosis., PMID:35752817
Combinatorial ASO-mediated therapy with low dose SMN and the protective modifier Chp1 is not sufficient to ameliorate SMA pathology hallmarks., PMID:35724821
Correction to: Zinc-finger protein 471 suppresses gastric cancer through transcriptionally repressing downstream oncogenic PLS3 and TFAP2A., PMID:35484334
Identification of Tumor-Suppressive miR-30e-3p Targets: Involvement of SERPINE1 in the Molecular Pathogenesis of Head and Neck Squamous Cell Carcinoma., PMID:35409173
X-Linked Osteogenesis Imperfecta Possibly Caused by a Novel Variant in PLS3., PMID:34946798
Osteogenesis imperfecta in 140 Turkish families: Molecular spectrum and, comparison of long-term clinical outcome of those with COL1A1/A2 and biallelic variants., PMID:34902613
BSG/CD147 and ACE2 receptors facilitate SARS-CoV-2 infection of human iPS cell-derived kidney podocytes., PMID:34816259
Identification of a Proteomic Signature of Senescence in Primary Human Mammary Epithelial Cells., PMID:34637314
Plastin-3 is a diagnostic and prognostic marker for pancreatic adenocarcinoma and distinguishes from diffuse large B-cell lymphoma., PMID:34348730
Early-Onset Osteoporosis., PMID:34236445
Diagnostic utility of next-generation sequence genetic panel testing in children presenting with a clinically significant fracture history., PMID:34091789
Cul3 regulates cytoskeleton protein homeostasis and cell migration during a critical window of brain development., PMID:34031387
Plastin 3 in health and disease: a matter of balance., PMID:34023917
Mapping of the amniotic fluid proteome of fetuses with congenital anomalies of the kidney and urinary tract identifies plastin 3 as a protein involved in glomerular integrity., PMID:33987838
Expression and Localization of Thrombospondins, Plastin 3, and STIM1 in Different Cartilage Compartments of the Osteoarthritic Varus Knee., PMID:33802838
Bone material properties and response to teriparatide in osteoporosis due to WNT1 and PLS3 mutations., PMID:33618074
Plastin 3 in X-Linked Osteoporosis: Imbalance of Ca2+-Dependent Regulation Is Equivalent to Protein Loss., PMID:33553175
Comprehensive Genetic Analysis of 128 Candidate Genes in a Cohort With Idiopathic, Severe, or Familial Osteoporosis., PMID:33195954
A novel mutation in PLS3 causes extremely rare X-linked osteogenesis imperfecta., PMID:33166085
Potential association of LOXL1 with peritoneal dissemination in gastric cancer possibly via promotion of EMT., PMID:33095806
Genetic modifiers ameliorate endocytic and neuromuscular defects in a model of spinal muscular atrophy., PMID:32938453
For research use only. Not for human or drug use.
