Catalog No.
RHN53001
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IHC: 1:50-1:100, WB: 1:500-1:1000
Target
Ikaros family zinc finger protein 3, IKZF3, ZNFN1A3, Zinc finger protein Aiolos
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q9UKT9
Applications
IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R2N91
Sequence variants influencing the regulation of serum IgG subclass levels., PMID:39277589
Transcriptional function of E2A, Ebf1, Pax5, Ikaros and Aiolos analyzed by in vivo acute protein degradation in early B cell development., PMID:39179932
Targeting Ikaros and Aiolos: reviewing novel protein degraders for the treatment of multiple myeloma, with a focus on iberdomide and mezigdomide., PMID:39054911
Genomic and immune signatures predict clinical outcome in newly diagnosed multiple myeloma treated with immunotherapy regimens., PMID:37945755
IKZF3 amplification frequently occurs in HER2-positive breast cancer and is a potential therapeutic target., PMID:36180600
Drug resistance and minimal residual disease in multiple myeloma., PMID:35582527
Comprehensive Analysis of lncRNA Expression Profile and the Potential Role of ENST00000604491 in Graves' Disease., PMID:35509980
Pyrotinib combined with thalidomide in advanced non-small-cell lung cancer patients harboring HER2 exon 20 insertions (PRIDE): protocol of an open-label, single-arm phase II trial., PMID:34530760
Effects of targeting the transcription factors Ikaros and Aiolos on B cell activation and differentiation in systemic lupus erythematosus., PMID:33727237
A hotspot mutation in transcription factor IKZF3 drives B cell neoplasia via transcriptional dysregulation., PMID:33689703
Urinary Cell Transcriptome Profiling and Identification of ITM2A, SLAMF6, and IKZF3 as Biomarkers of Acute Rejection in Human Kidney Allografts., PMID:32766436
Development of Label-Free Impedimetric Immunosensors for IKZF1 and IKZF3 Femtomolar Detection for Monitoring Multiple Myeloma Patients Treated with Lenalidomide., PMID:32591583
Rapid and deep-scale ubiquitylation profiling for biology and translational research., PMID:31953384
Genetic Variants Predisposing Most Strongly to Type 1 Diabetes Diagnosed Under Age 7 Years Lie Near Candidate Genes That Function in the Immune System and in Pancreatic β-Cells., PMID:31558544
Immunomodulatory drugs in the treatment of multiple myeloma., PMID:31187860
IMiDs prime myeloma cells for daratumumab-mediated cytotoxicity through loss of Ikaros and Aiolos., PMID:30228232
Cereblon modulator iberdomide induces degradation of the transcription factors Ikaros and Aiolos: immunomodulation in healthy volunteers and relevance to systemic lupus erythematosus., PMID:29945920
Loss of B-Cell Anergy in Type 1 Diabetes Is Associated With High-Risk HLA and Non-HLA Disease Susceptibility Alleles., PMID:29343548
Aiolos Overexpression in Systemic Lupus Erythematosus B Cell Subtypes and BAFF-Induced Memory B Cell Differentiation Are Reduced by CC-220 Modulation of Cereblon Activity., PMID:28848067
Whole-genome sequencing of chronic lymphocytic leukaemia reveals distinct differences in the mutational landscape between IgHVmut and IgHVunmut subgroups., PMID:28584254
Genetic variants associated with rheumatoid arthritis patients and serotypes in European populations., PMID:26939566
Aiolos collaborates with Blimp-1 to regulate the survival of multiple myeloma cells., PMID:26823144
PDK1 regulates VDJ recombination, cell-cycle exit and survival during B-cell development., PMID:23463102
Genome-wide identification of Ikaros targets elucidates its contribution to mouse B-cell lineage specification and pre-B-cell differentiation., PMID:23303821
Lacking of Aiolos accelerates pre-mature B cell apoptosis mediated by BCR signaling through elevation in cytochrome c release., PMID:19427336
CD93 is required for maintenance of antibody secretion and persistence of plasma cells in the bone marrow niche., PMID:19228948
Silencing and nuclear repositioning of the lambda5 gene locus at the pre-B cell stage requires Aiolos and OBF-1., PMID:18974788
Interferon regulatory factors 4 and 8 induce the expression of Ikaros and Aiolos to down-regulate pre-B-cell receptor and promote cell-cycle withdrawal in pre-B-cell development., PMID:17971486
Ikaros DNA-binding proteins as integral components of B cell developmental-stage-specific regulatory circuits., PMID:17363301
Pax5--a critical inhibitor of plasma cell fate., PMID:16918686
Aiolos is required for the generation of high affinity bone marrow plasma cells responsible for long-term immunity., PMID:14718515
Lack of the transcriptional coactivator OBF-1 prevents the development of systemic lupus erythematosus-like phenotypes in Aiolos mutant mice., PMID:12574333
The follicular versus marginal zone B lymphocyte cell fate decision is regulated by Aiolos, Btk, and CD21., PMID:11371362
Aiolos regulates B cell activation and maturation to effector state., PMID:9806640
Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors., PMID:9560339
For research use only. Not for human or drug use.
