Catalog No.
YHC98701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu21-Lys347
Predicted molecular weight
38.41 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P13611
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PG-M, Glial hyaluronate-binding protein, CSPG2, Versican core protein, Chondroitin sulfate proteoglycan core protein 2, Large fibroblast proteoglycan, GHAP, Chondroitin sulfate proteoglycan 2, VCAN
Wang, L., Wang, Y., Lu, T., Luo, C., Qiu, B., Huang, S., and Lin, Y. (2024a). Tetrahedral Framework Nucleic Acid Loaded miR‐23b Inhibits Synovial Inflammation and Cartilage Matrix Degradation in the Treatment of Rheumatoid Arthritis. Advanced Functional Materials 34, 2310749.
Ion Channel-Extracellular Matrix Interplay in Colorectal Cancer: A Network-Based Approach to Tumor Microenvironment Remodeling., PMID:40507957
Extracellular Matrix Alterations in Chronic Ischemic Cardiomyopathy Revealed by Quantitative Proteomics., PMID:40501991
Identification of adipose-proximal biomarkers in breast cancer using weighted gene co-expression network analysis., PMID:40498134
Downregulation of cGAS/STING expression in tumor cells by cancer-associated fibroblasts in colorectal cancer., PMID:40451897
Changes in Gene Transcription in Cumulus Cells from Women of Advanced Maternal Age under the Influence of Extracellular Vesicles from Follicular Fluid of Young Donors., PMID:40448879
Peripheral Choroid/RPE/Sclera as a Shared Pathogenic Hub: Multi-Tissue Transcriptomic Profiling Identifies Common Differentially Expressed Genes in Age-Related Macular Degeneration and Alzheimer's Disease., PMID:40411685
Screening and identification of versican as a sensitive biomarker and potential therapeutic target in basal cell carcinoma., PMID:40386063
Targeting Tumor Differentiation Grade-related Genes Prognostic Signature Including COL5A1 Based on Single-cell RNA-seq in Gastric Cancer., PMID:40386054
ST6GalNAc-I regulates tumor cell sialylation via NECTIN2/MUC5AC-mediated immunosuppression and angiogenesis in non-small cell lung cancer., PMID:40371640
Dynamic profiling of BMSC-dECM reveals accumulation of core matrisome proteins suppresses osteogenic differentiation and bone regeneration., PMID:40349957
A prognostic glycolysis-related gene signature in osteosarcoma: implications for metabolic programming, immune microenvironment, and drug response., PMID:40321814
The potential crosstalk genes and molecular mechanisms between systemic lupus erythematosus and periodontitis., PMID:40309038
Plasma Circulating Proteins and Intracranial Aneurysm Susceptibility: A Proteome-Wide Mendelian Randomization Analysis., PMID:40294794
Identification of novel plasma proteins as promising noninvasive biomarker for early diagnosis and surveillance of pancreatic ductal adenocarcinoma., PMID:40285860
Identification of Versican as a target gene of the transcription Factor ZNF587B in ovarian cancer., PMID:40228636
Localization, Proteolytic Processing, and Binding Partners of Versican Isoforms in Vascular Lesions of Pulmonary Arterial Hypertension., PMID:40219589
Loss of ADAMTS5 promotes vascular calcification via versican/integrin β1/FAK signal., PMID:40215897
Wnt signaling pathway and retinoic acid signaling pathway involved in delamination and migration of chicken trunk NCCs and contributing to HVP phenotype., PMID:40209469
Indole-3-lactic acid derived from tryptophan metabolism promotes trophoblast migration and invasion by activating the AhR/VCAN pathway., PMID:40153926
The landscape of N6-methyladenosine in localized primary prostate cancer., PMID:40128621
Identification of Pivotal ceRNA Networks Associated with Stanford-A Aortic Dissection via Integrated Bioinformatics Analysis., PMID:40123810
Fibroblast-derived versican exacerbates periodontitis progression by regulating macrophage migration and inflammatory cytokine secretion., PMID:40112905
Comprehensive analysis of CLEC family genes in gastric cancer prognosis immune response and treatment., PMID:39966377
MMP19 in vascular smooth muscle cells protects against thoracic aortic aneurysm and dissection via the MMP19/Aggrecan/Wnt/β-catenin axis., PMID:39954937
Expression of Versican in the Retina and Its Implication in Retinal Disease., PMID:39930232
Clinical and Prognostic Implications of an Alternative Splicing-related Risk Model Based on TP53 Status in Breast Cancer., PMID:39916426
Unraveling the gender-specific molecular landscape of lung squamous cell carcinoma progression., PMID:39895519
Identification of novel cytoskeleton protein involved in spermatogenic cells and sertoli cells of non-obstructive azoospermia based on microarray and bioinformatics analysis., PMID:39863862
Revealing VCAN as a Potential Common Diagnostic Biomarker of Renal Tubules and Glomerulus in Diabetic Kidney Disease Based on Machine Learning, Single-Cell Transcriptome Analysis and Mendelian Randomization., PMID:39849979
A novel piperine derivative HJJ_3_5 inhibits colorectal cancer progression by modulating EMT signaling pathways., PMID:39842333
The MIR181A2HG/miR-5680/VCAN-CD44 Axis Regulates Gastric Cancer Lymph Node Metastasis by Promoting M2 Macrophage Polarization., PMID:39823128
Gene expression and immunohistochemistry analysis of ADAMTS-1 and its substrates in odontogenic keratocyst., PMID:39762885
Relugolix reduces leiomyoma extracellular matrix production via the transforming growth factor-beta pathway., PMID:39733929
Identification of SPP1 + macrophages as an immune suppressor in hepatocellular carcinoma using single-cell and bulk transcriptomics., PMID:39691723
Long non-coding RNA VCAN-AS1 promotes gastric cancer progression via the HuR/F11R pathway., PMID:39678543
Role of versican in extracellular matrix formation: analysis in 3D culture., PMID:39656505
IDENTIFICATION AND VERIFICATION OF FEATURE BIOMARKERS ASSOCIATED WITH CHOLINE METABOLISM IN SEPSIS-INDUCED CARDIOMYOPATHY., PMID:39637364
Diagnostic potential of genomic blood biomarkers of pulmonary fibrosis in a prospective cohort., PMID:39625896
Promotor Hypomethylation Mediated Upregulation of VCAN Targets Twist1 to Promote EndMT in Hypoxia-Induced Pulmonary Hypertension., PMID:39578365
Multitranscriptome analysis reveals stromal cells in the papillary dermis to promote angiogenesis in psoriasis vulgaris., PMID:39569441
VCAN in the extracellular matrix drives glioma recurrence by enhancing cell proliferation and migration., PMID:39554845
Transcriptome Sequencing-Based Screening of Key Melatonin-Related Genes in Ischemic Stroke., PMID:39519172
Increased levels of versican and insulin-like growth factor 1 in peritumoral mammary adipose tissue are related to aggressiveness in estrogen receptor-positive breast cancer., PMID:39501160
Gene expression profiles of neuroinflammatory responses in broad brain regions in rats repeatedly administered with N-methyl-N-nitrosourea for 28 days., PMID:39496385
Regulation of versican expression in macrophages is mediated by canonical type I interferon signaling via ISGF3., PMID:39400584
Relationship between fat embolism and endothelial glycocalyx., PMID:39383615
Immunohistochemical Evaluation of Potential Biomarkers for Targeted Intraoperative Fluorescence Imaging in Endometriosis: Towards Optimizing Surgical Treatment., PMID:39373851
Multimodal Evaluation and Management of Wagner Syndrome-Three Patients from an Affected Family., PMID:39336769
The oncogenic ADAMTS1-VCAN-EGFR cyclic axis drives anoikis resistance and invasion in renal cell carcinoma., PMID:39333870
Gene co-expression network and differential expression analyses reveal key genes for weaning weight in Simmental-Holstein crossbred cattle., PMID:39301708
For research use only. Not for human or drug use.
