Catalog No.
RHJ88001
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
FCM: 1:20-1:100, IF: 1:50-1:200, IHC: 1:100-1:200, WB: 1:1000-1:2000
Target
IRS2, Insulin receptor substrate 2, IRS-2
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q9Y4H2
Applications
FCM, IF, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R2L12
Anti-OAcGD2 antibody in combination with ceramide kinase inhibitor mediates potent antitumor cytotoxicity against breast cancer and diffuse intrinsic pontine glioma cells., PMID:39395135
The IGF-Independent Role of IRS-2 in the Secretion of MMP-9 Enhances the Growth of Prostate Carcinoma Cell Line PC3., PMID:37894751
Rare ocular toxicity induced by pertuzumab/QL1209 in healthy chinese subjects: case reports and whole-exome sequencing analysis., PMID:35596833
Mast Cells and Basophils in the Defense against Ectoparasites: Efficient Degradation of Parasite Anticoagulants by the Connective Tissue Mast Cell Chymases., PMID:34884431
INitial Steps of Insulin Action in Parotid Glands of Male Wistar Rats., PMID:34345983
GLP-1 preserves β cell function via improvement on islet insulin signaling in high fat diet feeding mice., PMID:33307381
Phosphorylated and O-GlcNAc Modified IRS-1 (Ser1101) and -2 (Ser1149) Contribute to Human Diabetes Type II., PMID:32798372
Novel Somatic Genetic Variants as Predictors of Resistance to EGFR-Targeted Therapies in Metastatic Colorectal Cancer Patients., PMID:32796636
Anti-EGFR therapy in metastatic colorectal cancer: mechanisms and potential regimens of drug resistance., PMID:32665850
Distribution of Bacterial α1,3-Galactosyltransferase Genes in the Human Gut Microbiome., PMID:31998300
Immunotherapy With Antiprogrammed Cell Death 1 Antibody Improves Outcome in a Mouse Model of Spinal Cord Injury Followed by Staphylococcus aureus Pneumonia., PMID:30303841
Infliximab ameliorates tumor necrosis factor-alpha-induced insulin resistance by attenuating PTP1B activation in 3T3L1 adipocytes in vitro., PMID:30260514
Interleukin-22 level is negatively correlated with neutrophil recruitment in the lungs in a Pseudomonas aeruginosa pneumonia model., PMID:28887540
PROTECTIVE EFFECT OF CAMEL MILK AS ANTI-DIABETIC SUPPLEMENT: BIOCHEMICAL, MOLECULAR AND IMMUNOHISTOCHEMICAL STUDY., PMID:28638873
Glucocorticoid Receptor ChIP-Seq Identifies PLCD1 as a KLF15 Target that Represses Airway Smooth Muscle Hypertrophy., PMID:28375666
Single nucleotide polymorphisms in the IGF-IRS pathway are associated with outcome in mCRC patients enrolled in the FIRE-3 trial., PMID:28369940
Expression of the Tumor-associated Mucin 1 Epitope Analyzed with the Humanized PankoMab-GEX™ Antibody in Malignant and Normal Tissues of the Head and Neck., PMID:27272845
IRS2 silencing increases apoptosis and potentiates the effects of ruxolitinib in JAK2V617F-positive myeloproliferative neoplasms., PMID:26755644
Avatars Identify Genetic Sources of Drug Response., PMID:26573662
The genomic landscape of response to EGFR blockade in colorectal cancer., PMID:26416732
Insulin family polymorphisms in pregnancies complicated by small for gestational age infants., PMID:26089371
Ablation of Dicer leads to widespread perturbation of signaling pathways., PMID:26032504
P38 plays an important role in glucolipotoxicity-induced apoptosis in INS-1 cells., PMID:24734256
Insulin and metabolic stress stimulate multisite serine/threonine phosphorylation of insulin receptor substrate 1 and inhibit tyrosine phosphorylation., PMID:24652289
Insulin-dependent transcriptional control in L6 rat myotubes is associated with modulation of histone acetylation and accumulation of the histone variant H2A.Z in the proximity of the transcriptional start site., PMID:24471919
Molecular predictors of sensitivity to the insulin-like growth factor 1 receptor inhibitor Figitumumab (CP-751,871)., PMID:24107449
The consequences of long-term glycogen synthase kinase-3 inhibition on normal and insulin resistant rat hearts., PMID:23820981
Identification of the amino acids 300-600 of IRS-2 as 14-3-3 binding region with the importance of IGF-1/insulin-regulated phosphorylation of Ser-573., PMID:22912850
Conventional but not high-purity dialysis fluid induces apoptosis and insulin resistance in adipocytes in vitro., PMID:22562372
An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers., PMID:22476196
Action of metformin on the insulin-signaling pathway and on glucose transport in human granulosa cells., PMID:21209036
Insulin-induced serine phosphorylation of IRS-2 via ERK1/2 and mTOR: studies on the function of Ser675 and Ser907., PMID:21098738
SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in mice., PMID:20847051
Molecular analysis of non-small cell lung cancer identifies subsets with different sensitivity to insulin-like growth factor I receptor inhibition., PMID:20670944
IGF activation in a molecular subclass of hepatocellular carcinoma and pre-clinical efficacy of IGF-1R blockage., PMID:20206398
Molecular predictors of response to a humanized anti-insulin-like growth factor-I receptor monoclonal antibody in breast and colorectal cancer., PMID:19671761
Association between total immunoglobulin E and antibody responses to naturally acquired Ascaris lumbricoides infection and polymorphisms of immune system-related LIG4, TNFSF13B and IRS2 genes., PMID:19604268
Insulin receptor substrate-2 in beta-cells decreases diabetes in nonobese diabetic mice., PMID:19574401
Insulin receptor substrate-2 mediated insulin-like growth factor-I receptor overexpression in pancreatic adenocarcinoma through protein kinase Cdelta., PMID:19190347
Green tea (-)-epigallocatechin gallate inhibits insulin stimulation of 3T3-L1 preadipocyte mitogenesis via the 67-kDa laminin receptor pathway., PMID:19176763
Gene silencing of phogrin unveils its essential role in glucose-responsive pancreatic beta-cell growth., PMID:19073770
Fulminant type 1 diabetes mellitus observed in insulin receptor substrate 2 deficient mice., PMID:18618219
Interleukin-10 is a protective factor against diet-induced insulin resistance in liver., PMID:18267346
Obestatin promotes survival of pancreatic beta-cells and human islets and induces expression of genes involved in the regulation of beta-cell mass and function., PMID:18162507
IL-4 protects the B-cell lymphoma cell line CH31 from anti-IgM-induced growth arrest and apoptosis: contribution of the PI-3 kinase/AKT pathway., PMID:17968425
Mammalian target of rapamycin (mTOR) inhibition activates phosphatidylinositol 3-kinase/Akt by up-regulating insulin-like growth factor-1 receptor signaling in acute myeloid leukemia: rationale for therapeutic inhibition of both pathways., PMID:17878402
Insulin-like growth factor-1 potentiates platelet activation via the IRS/PI3Kalpha pathway., PMID:17827393
Dok-1 is a positive regulator of IL-4 signalling and IgE response., PMID:17827176
Identification of a WD40 repeat-containing isoform of PHIP as a novel regulator of beta-cell growth and survival., PMID:17636024
Insulin-like growth factor receptor as a therapeutic target in head and neck cancer., PMID:17634559
For research use only. Not for human or drug use.
