Catalog No.
RHJ66002
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
FCM: 1:20-1:100, IF: 1:50-1:200, IHC: 1:100-1:200, IP: 1:20-1:50, WB: 1:1000-1:2000
Target
KIAA0457, Disrupted in schizophrenia 1 protein, DISC1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q9NRI5
Applications
FCM, IF, IHC, IP, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R2K42
Antibody screening data of human midgestation liver cells with a focus on hematopoietic, liver sinusoidal endothelial, and hepatoblast cell-populations., PMID:36474299
Quantification of a Neurological Protein in a Single Cell Without Amplification., PMID:35722002
The composition of peripheral immunocompetent cell subpopulations and cytokine content in the brain structures of mutant Disc1-Q31L mice., PMID:33959693
Immune and Inflammatory Determinants Underlying Alzheimer's Disease Pathology., PMID:32090272
Transmembrane protein 108 involves in adult neurogenesis in the hippocampal dentate gyrus., PMID:30651970
A New T. gondii Mouse Model of Gene-Environment Interaction Relevant to Psychiatric Disease., PMID:30631636
Host-parasite interaction associated with major mental illness., PMID:30127472
Biophysical insights from a single chain camelid antibody directed against the Disrupted-in-Schizophrenia 1 protein., PMID:29324815
Electrical Stimulation Using Conductive Polymer Polypyrrole Counters Reduced Neurite Outgrowth of Primary Prefrontal Cortical Neurons from NRG1-KO and DISC1-LI Mice., PMID:28198409
Protein multiplicity can lead to misconduct in western blotting and misinterpretation of immunohistochemical staining results, creating much conflicting data., PMID:27908506
Immunohistochemical evaluation of the GABAergic neuronal system in the prefrontal cortex of a DISC1 knockout mouse model of schizophrenia., PMID:27421906
Catecholaminergic neuronal network dysfunction in the frontal lobe of a genetic mouse model of schizophrenia., PMID:26333915
Aggregation of the protein TRIOBP-1 and its potential relevance to schizophrenia., PMID:25333879
Disrupted in schizophrenia 1 modulates medial prefrontal cortex pyramidal neuron activity through cAMP regulation of transient receptor potential C and small-conductance K+ channels., PMID:24560582
Maternal immune activation during gestation interacts with Disc1 point mutation to exacerbate schizophrenia-related behaviors in mice., PMID:23637159
A Disc1 mutation differentially affects neurites and spines in hippocampal and cortical neurons., PMID:23396153
Interaction of DISC1 with the PTB domain of Tensin2., PMID:23233134
Proteomic, genomic and translational approaches identify CRMP1 for a role in schizophrenia and its underlying traits., PMID:22798627
Behavioral alterations associated with targeted disruption of exons 2 and 3 of the Disc1 gene in the mouse., PMID:21903668
Impaired NMDA receptor transmission alters striatal synapses and DISC1 protein in an age-dependent manner., PMID:21436042
Biochemical and functional interaction of disrupted-in-schizophrenia 1 and amyloid precursor protein regulates neuronal migration during mammalian cortical development., PMID:20685985
DISC1 regulates cell-cell adhesion, cell-matrix adhesion and neurite outgrowth., PMID:20479754
HOXB13, a target of DNMT3B, is methylated at an upstream CpG island, and functions as a tumor suppressor in primary colorectal tumors., PMID:20454457
Oligomer assembly of the C-terminal DISC1 domain (640-854) is controlled by self-association motifs and disease-associated polymorphism S704C., PMID:19583211
Survey of schizophrenia and bipolar disorder candidate genes using chromatin immunoprecipitation and tiled microarrays (ChIP-chip)., PMID:19225952
[Diagnostic value of anti-alpha-fodrin antibody testing for Sjögren's syndrome: a meta-analysis]., PMID:19080074
Recruitment of PCM1 to the centrosome by the cooperative action of DISC1 and BBS4: a candidate for psychiatric illnesses., PMID:18762586
Disrupted in Schizophrenia 1 (DISC1) is a multicompartmentalized protein that predominantly localizes to mitochondria., PMID:15121183
For research use only. Not for human or drug use.
