Anti-CASP10 Antibody (R2J52)

Catalog No.

RHJ33802

Species reactivity

Human

Host species

Rabbit

Isotype

IgG

Clonality

Monoclonal

Tested applications

FCM: 1:20-1:100, IHC: 1:100-1:200, IP: 1:20-1:50, WB: 1:1000-1:2000

Target

FAS-associated death domain protein interleukin-1B-converting enzyme 2, FLICE2, CASP-10, MCH4, ICE-like apoptotic protease 4, Apoptotic protease Mch-4, CASP10, Caspase-10

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q92851

Applications

FCM, IHC, IP, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.

Clone ID

R2J52

Next Generation Sequencing for Detecting Somatic FAS Mutations in Patients With Autoimmune Lymphoproliferative Syndrome., PMID:33995372

Updated Understanding of Autoimmune Lymphoproliferative Syndrome (ALPS)., PMID:25663566

Exonic deletion of CASP10 in a patient presenting with systemic juvenile idiopathic arthritis, but not with autoimmune lymphoproliferative syndrome type IIa., PMID:21382177

Involvement of mitochondria and recruitment of Fas/CD95 signaling in lipid rafts in resveratrol-mediated antimyeloma and antileukemia actions., PMID:19561642

Caspase-10 in mouse or not?, PMID:16809511

The broad spectrum of autoimmune lymphoproliferative disease: molecular bases, clinical features and long-term follow-up in 31 patients., PMID:16537120

HIV-1 Tat protein concomitantly down-regulates apical caspase-10 and up-regulates c-FLIP in lymphoid T cells: a potential molecular mechanism to escape TRAIL cytotoxicity., PMID:15573381

FLICE/caspase-8 activation triggers anoikis induced by beta1-integrin blockade in human keratinocytes., PMID:15507484

Taxol induces caspase-10-dependent apoptosis., PMID:15452117

In the erythroleukemic cell line HEL Prostate-apoptosis-response-gene-4 (par-4) fails to down-regulate Bcl-2 and to promote apoptosis., PMID:15359646

LF 15-0195 immunosuppressive agent enhances activation-induced T-cell death by facilitating caspase-8 and caspase-10 activation at the DISC level., PMID:12393594

Human fetal retinal pigment epithelium induces apoptosis in human T-cell line Jurkat which is independent from its expression of TRAIL., PMID:12221529

Death effector domain-only polypeptides of caspase-8 and -10 specifically inhibit death receptor-induced cell death., PMID:11855814

Death receptor recruitment of endogenous caspase-10 and apoptosis initiation in the absence of caspase-8., PMID:11583996

Extended polyglutamine selectively interacts with caspase-8 and -10 in nuclear aggregates., PMID:11550089

Progressive resistance to apoptosis in a cell lineage model of human proliferative breast disease., PMID:11353788

Quantification of active caspase 3 in apoptotic cells., PMID:10933864

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